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How to get fromMainz to Palermoby plane, train (Trenitalia), car, car ferry, bus, or train

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There are 10 ways to get from Mainz to Palermo by plane, train (Trenitalia), car, car ferry, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Frankfurt to Palermo Airport

    best
    1. Fly from Frankfurt (FRA) to Palermo Airport (PMO)plane plane FRA - PMO
    5h 37m
    €82–237

  2. Bus to Hahn, fly to Palermo Airport

    cheapest
    1. Take the bus from Mainz, Hauptbahnhof to Hahnbus bus
    2. Fly from Hahn (HHN) to Palermo Airport (PMO)plane plane HHN - PMO
    6h 29m
    €62–221

  3. Train

    1. Take the train from Frankfurt to Basel SBBtrain train 43
    2. Take the train from Basel SBB to Luganotrain train Ec
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Roma Terminitrain train
    5. Take the train from Roma Termini to Palermo Centraletrain train Ic
    25h 35m
    €259–562

  4. Drive, car ferry

    1. Drive from Mainz to Port of Genoacar car
    2. Take the carferry from Port of Genoa to Port of Palermocarferry car ferry
    27h 12m
    €244–358

  5. Bus

    1. Take the bus from Mühlheim am Main to Palermo Piazza Cairolibus bus
    30h 25m
    €264–364

  6. Fly Frankfurt to Catania–Fontanarossa Airport, bus

    1. Fly from Frankfurt (FRA) to Catania–Fontanarossa Airport (CTA)plane plane FRA - CTA
    2. Take the bus from Catania Fontanarossa Airport Bus Stop to Palermo Via Tommaso Fazellobus bus
    8h 18m
    €95–259

  7. Train to Cologne Bonn Airport, fly to Palermo Airport

    1. Take the train from Frankfurt to Siegburg Bftrain train
    2. Fly from Cologne Bonn Airport (CGN) to Palermo Airport (PMO)plane plane CGN - PMO
    7h 20m
    €90–377

  8. Train, bus

    1. Take the train from Frankfurt to Basel SBBtrain train 43
    2. Take the train from Basel SBB to Domodossolatrain train Ec
    3. Take the bus from Domodossola to Rho Fiera Milanobus bus Re4
    4. Take the train from Milano Rogoredo to Roma Terminitrain train
    5. Take the train from Roma Termini to Palermo Centraletrain train Ic
    26h 19m

  9. Bus via Milan

    1. Take the bus from Mainz central train station to Milanbus bus FlixBus 476
    2. Take the bus from Milano, Autostazione Lampugnano to Palermobus bus N597
    35h
    €206–307

  10. Bus #2

    1. Take the bus from Wiesbaden Gartenfeldstraße P+R to Palermo Piazza Cairolibus bus
    38h 6m
    €292–402

Mainz to Palermo by train

Calendar28Weekly Trains
Duration25h 35mAverage Duration
Ticket€259Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mainz to Palermo.ExpandLaunch map view
  • Distance: 1,424.6 km
  • Duration: 5h 37m

What companies run services between Mainz, Germany and Palermo, Italy?

Lufthansa and ITA Airways fly from Frankfurt (FRA) to Palermo Airport (PMO) once daily. Alternatively, you can take a train from Mainz, Römisches Theater to Palermo Centrale via Frankfurt, Basel SBB, Lugano, Milano Centrale, and Roma Termini in around 25h 35m.

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