There are 8 ways to get from Mainz to Palermo by plane, train (Trenitalia), car, car ferry, bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Frankfurt
best- Fly from Frankfurt (FRA) to Palermo Airport (PMO)plane FRA - PMO
5h 41m€100–288Bus
cheapest- Take the bus from Mainz central train station to Milano, Autostazione Lampugnanobus 476
- Take the bus from Milano, Autostazione Lampugnano to Palermobus N597
35h€81–273Train
- Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
- Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain 20 / ...
- Take the train from Basel SBB to Zürich HBtrain Ice / ...
- Take the train from Zürich HB to Milano Centraletrain Ec
- Take the train from Milano Centrale to Roma Terminitrain Fr / ...
- Take the train from Roma Termini to Palermo Centraletrain Ic
25h 50m€225–575Drive, car ferry
- Drive from Mainz to Port of Genoacar
- Take the car ferry from Port of Genoa to Port of Palermocarferry
28h 27m€185–320Train to Stuttgart Airport, fly
- Take the train from Mainz, Hauptbahnhof to Hauptbahnhoftrain
- Fly from Stuttgart Airport (STR) to Palermo Airport (PMO)plane STR - PMO
7h 14m€120–362Bus to Hahn, fly
- Take the bus from Mainz Short-term parking lot Am Schlag to Frankfurt Hahn Airportbus
- Fly from Hahn (HHN) to Palermo Airport (PMO)plane HHN - PMO
6h 37m€110–316Train, car ferry
- Take the train from Mainz Hbf to Zürich HBtrain
- Take the train from Zürich HB to Genova P. Principetrain Ec
- Take the car ferry from Port of Genoa to Port of Palermocarferry
36h 3m€270–637Train, bus
- Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
- Take the bus from Mannheim Central Bus Station to Milanbus
- Take the bus from Milano, San Donato M3 to Palermo Via Tommaso Fazellobus
36h 20m€104–175
Mainz to Palermo by train
Questions & Answers
The cheapest way to get from Mainz to Palermo is to train and bus which costs €100 - €180 and takes 36h 20m.
The fastest way to get from Mainz to Palermo is to fly which takes 5h 41m and costs €100 - €290.
No, there is no direct bus from Mainz station to Palermo. However, there are services departing from Mainz central train station and arriving at Palermo via Milano, Autostazione Lampugnano. The journey, including transfers, takes approximately 35h.
No, there is no direct train from Mainz to Palermo. However, there are services departing from Mainz, Römisches Theater and arriving at Palermo Centrale via Mannheim, Hauptbahnhof, Basel SBB, Zürich HB, Milano Centrale and Roma Termini. The journey, including transfers, takes approximately 25h 50m.
The distance between Mainz and Palermo is 1425 km.
The best way to get from Mainz to Palermo without a car is to train which takes 25h 50m and costs €220 - €600.
It takes approximately 5h 41m to get from Mainz to Palermo, including transfers.
Mainz to Palermo bus services, operated by FlixBus, depart from Mainz central train station.
Mainz to Palermo train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Römisches Theater station.
The best way to get from Mainz to Palermo is to fly which takes 5h 41m and costs €100 - €290. Alternatively, you can train, which costs €220 - €600 and takes 25h 50m, you could also bus, which costs €80 - €280 and takes 35h.
What companies run services between Mainz, Germany and Palermo, Italy?
Lufthansa, Air Dolomiti, and two other airlines fly from Frankfurt (FRA) to Palermo Airport (PMO) 4 times a day. Alternatively, you can take a train from Mainz, Römisches Theater to Palermo Centrale via Mannheim, Hauptbahnhof, Basel SBB, Zürich HB, Milano Centrale, and Roma Termini in around 25h 50m.
- Website
- ita-airways.com
Flights from Frankfurt to Palermo Airport via Milan Linate
- Ave. Duration
- 4h 28m
- When
- Every day
- Estimated price
- €80–240
Flights from Stuttgart Airport to Palermo Airport via Rome
- Ave. Duration
- 4h 15m
- When
- Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €100–190
- Website
- swiss.com
Flights from Frankfurt to Palermo Airport via Zurich
- Ave. Duration
- 4h 25m
- When
- Thursday and Sunday
- Estimated price
- €75–310
Flights from Stuttgart Airport to Palermo Airport via Zurich
- Ave. Duration
- 3h 35m
- When
- Sunday
- Estimated price
- €80–340
- Website
- lufthansa.com
Flights from Frankfurt to Palermo Airport
- Ave. Duration
- 2h 15m
- When
- Saturday
- Estimated price
- €120–390
Flights from Stuttgart Airport to Palermo Airport via Munich
- Ave. Duration
- 4h 5m
- When
- Sunday
- Estimated price
- €120–410
- Website
- ryanair.com
Flights from Hahn to Palermo Airport
- Ave. Duration
- 2h 20m
- When
- Monday and Friday
- Estimated price
- €90–290
Flights from Hahn to Palermo Airport via Bari
- Ave. Duration
- 5h 40m
- When
- Monday
- Estimated price
- €90–290
- Website
- eurowings.com
Flights from Stuttgart Airport to Palermo Airport
- Ave. Duration
- 2h 5m
- When
- Wednesday
- Estimated price
- €100–190
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Estimated price
- €13–19
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 1h 1m
- Frequency
- Twice daily
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 21m
- Frequency
- Hourly
- Estimated price
- €30–80
- Website
- https://int.bahn.de/en
Train from Mainz, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 1h 30m
- Frequency
- Every 3 hours
- Estimated price
- €30–75
- Website
- https://int.bahn.de/en
- Phone
- +31 30 751 5155
- Website
- ns.nl
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 50m
- Frequency
- Once daily
- Estimated price
- €40–140
- Website
- https://www.ns.nl/en
- 2nd Class
- €40–60
- 1st Class
- €80–140
Train from Mainz Hbf to Zürich HB
- Ave. Duration
- 6h 22m
- Frequency
- Once daily
- Estimated price
- €70–240
- Website
- https://www.ns.nl/en
- 2nd Class
- €70–110
- 1st Class
- €140–240
- Phone
- +41 848 446 688
- Website
- sbb.ch
Train from Basel SBB to Zürich HB
- Ave. Duration
- 1h 12m
- Frequency
- Every 20 minutes
- Estimated price
- €21–45
- Website
- https://www.sbb.ch/en
Train from Zürich HB to Milano Centrale
- Ave. Duration
- 3h 17m
- Frequency
- Once daily
- Estimated price
- €75–140
- Website
- https://www.sbb.ch/en
Train from Zürich HB to Genova P. Principe
- Ave. Duration
- 6h 37m
- Frequency
- Once daily
- Estimated price
- €140–260
- Website
- https://www.sbb.ch/en
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 12m
- Frequency
- Every 30 minutes
- Estimated price
- €45–110
- Schedules at
- trenitalia.com
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 39m
- Frequency
- Hourly
- Estimated price
- €45–120
- Website
- https://www.italotreno.it/en
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Palermo Centrale
- Ave. Duration
- 11h 44m
- Frequency
- Once daily
- Estimated price
- €40–110
- Website
- https://www.trenitalia.com/en.html
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Mainz central train station to Milano, Autostazione Lampugnano
- Ave. Duration
- 12h 5m
- Frequency
- Twice daily
- Estimated price
- €35–110
- Website
- https://www.flixbus.co.uk
Bus from Milano, Autostazione Lampugnano to Palermo
- Ave. Duration
- 21h 55m
- Frequency
- Once daily
- Estimated price
- €45–170
- Website
- https://www.flixbus.co.uk
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Milano, Autostazione Lampugnano to Palermo
- Ave. Duration
- 21h 45m
- Frequency
- Twice a week
- Estimated price
- €60–90
- Schedules at
- autoservizisalemi.it
Bus from Milano, San Donato M3 to Palermo Via Tommaso Fazello
- Ave. Duration
- 21h
- Frequency
- Twice a week
- Estimated price
- €55–85
- Schedules at
- autoservizisalemi.it
- info@flibco.com
- Website
- flibco.com
Bus from Mainz Short-term parking lot Am Schlag to Frankfurt Hahn Airport
- Ave. Duration
- 1h 15m
- Frequency
- Every 2 hours
- Estimated price
- €17–20
- Website
- https://www.flibco.com/en
- Phone
- +39 080 3112335
- info@marinobus.it
- Website
- marinobus.it
Bus from Mannheim Central Bus Station to Milan
- Ave. Duration
- 12h 5m
- Frequency
- Twice a week
- Estimated price
- €35–70
- Website
- https://marinobus.it/en/
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Car ferry from Port of Genoa to Port of Palermo
- Ave. Duration
- 20h 45m
- Frequency
- Once daily
- Estimated price
- €60–140
- Website
- https://www.gnv.it/en
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More Questions & Answers
Mainz to Palermo bus services, operated by FlixBus, arrive at Milano, Autostazione Lampugnano station.
Mainz to Palermo train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Mannheim, Hauptbahnhof station.
Book your Mainz to Palermo train tickets online with Omio.
Book your Mainz to Palermo bus tickets online with Omio and FlixBus.
There are 5713+ hotels available in Palermo.


























































