There are 9 ways to get from Mainz to Palermo by plane, train (Trenitalia), car, car ferry, bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Frankfurt to Palermo Airport
best- Fly from Frankfurt (FRA) to Palermo Airport (PMO)FRA - PMO
5h 39m€95–238Bus to Hahn, fly to Palermo Airport
cheapest- Take the bus from Mainz Short-term parking lot Am Schlag to Frankfurt Hahn Airport
- Fly from Hahn (HHN) to Palermo Airport (PMO)HHN - PMO
6h 35m€85–316Train
- Take the train from Mainz, Römisches Theater to Mannheim, HauptbahnhofS6 / ...
- Take the train from Mannheim, Hauptbahnhof to Basel SBB20 / ...
- Take the train from Basel SBB to Zürich HBIce / ...
- Take the train from Zürich HB to Milan RogoredoEc
- Take the train from Milan Rogoredo to Roma Termini
- Take the train from Roma Termini to Palermo CentraleIc
26h 12m€225–585Drive, car ferry
- Drive from Mainz to Port of Genoa
- Take the car ferry from Port of Genoa to Port of Palermo
28h 26m€183–308Bus
- Take the bus from Mainz central train station to Milano, Autostazione Lampugnano476
- Take the bus from Milano, Autostazione Lampugnano to PalermoN597
35h 10m€92–275Fly Frankfurt to Catania–Fontanarossa Airport, bus
- Fly from Frankfurt (FRA) to Catania–Fontanarossa Airport (CTA)FRA - CTA
- Take the bus from Catania Fontanarossa Airport Bus Stop to Palermo Via Tommaso Fazello
7h 56m€108–310Train to Cologne Bonn Airport, fly to Palermo Airport
- Take the train from Frankfurt to Siegburg Bf
- Fly from Cologne Bonn Airport (CGN) to Palermo Airport (PMO)CGN - PMO
7h 28m€108–393Train, car ferry
- Take the train from Mainz Hbf to Zürich HB
- Take the train from Zürich HB to Genova P. PrincipeEc
- Take the car ferry from Port of Genoa to Port of Palermo
36h 3m€270–627Train, bus
- Take the train from Mainz, Römisches Theater to Mannheim, HauptbahnhofS6 / ...
- Take the bus from Mannheim Central Bus Station to Milan
- Take the bus from Milano, San Donato M3 to Palermo Via Tommaso Fazello
36h 22m€104–160
Mainz to Palermo by train
Questions & Answers
The cheapest way to get from Mainz to Palermo is to bus and fly which costs €85 - €320 and takes 6h 35m.
The fastest way to get from Mainz to Palermo is to fly which takes 5h 39m and costs €95 - €240.
No, there is no direct bus from Mainz station to Palermo. However, there are services departing from Mainz central train station and arriving at Palermo via Milano, Autostazione Lampugnano. The journey, including transfers, takes approximately 35h 10m.
No, there is no direct train from Mainz to Palermo. However, there are services departing from Mainz, Römisches Theater and arriving at Palermo Centrale via Mannheim, Hauptbahnhof, Basel SBB, Zürich HB, Milan Rogoredo and Roma Termini. The journey, including transfers, takes approximately 26h 12m.
The distance between Mainz and Palermo is 1425 km.
The best way to get from Mainz to Palermo without a car is to train which takes 26h 12m and costs €220 - €600.
It takes approximately 5h 39m to get from Mainz to Palermo, including transfers.
Mainz to Palermo bus services, operated by FlixBus, depart from Mainz central train station.
Mainz to Palermo train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Römisches Theater station.
The best way to get from Mainz to Palermo is to fly which takes 5h 39m and costs €95 - €240. Alternatively, you can train, which costs €220 - €600 and takes 26h 12m, you could also bus, which costs €90 - €280 and takes 35h 10m.
What companies run services between Mainz, Germany and Palermo, Italy?
Lufthansa, Swiss, and two other airlines fly from Frankfurt (FRA) to Palermo Airport (PMO) once daily. Alternatively, you can take a train from Mainz, Römisches Theater to Palermo Centrale via Mannheim, Hauptbahnhof, Basel SBB, Zürich HB, Milan Rogoredo, and Roma Termini in around 26h 12m.
- Website
- ryanair.com
Flights from Hahn to Palermo Airport
- Ave. Duration
- 2h 20m
- When
- Monday, Tuesday, Wednesday, and Friday
- Estimated price
- €65–290
Flights from Hahn to Palermo Airport via Rome
- Ave. Duration
- 5h 2m
- When
- Monday, Friday, and Saturday
- Estimated price
- €65–290
Flights from Hahn to Palermo Airport via Bari
- Ave. Duration
- 5h 40m
- When
- Monday
- Estimated price
- €65–290
Flights from Cologne Bonn Airport to Palermo Airport
- Ave. Duration
- 2h 25m
- When
- Monday, Wednesday, Friday, and Saturday
- Estimated price
- €60–260
Flights from Cologne Bonn Airport to Palermo Airport via Bologna
- Ave. Duration
- 4h
- When
- Monday, Wednesday, and Friday
- Estimated price
- €60–260
Flights from Cologne Bonn Airport to Palermo Airport via Rome
- Ave. Duration
- 4h 20m
- When
- Wednesday and Saturday
- Estimated price
- €60–260
- Website
- ita-airways.com
Flights from Frankfurt to Palermo Airport via Milan Linate
- Ave. Duration
- 4h 35m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €80–220
Flights from Frankfurt to Catania–Fontanarossa Airport
- Ave. Duration
- 2h 25m
- When
- Monday, Wednesday, Saturday, and Sunday
- Estimated price
- €170–340
Flights from Frankfurt to Catania–Fontanarossa Airport via Milan Linate
- Ave. Duration
- 4h 6m
- When
- Every day
- Estimated price
- €65–200
Flights from Cologne Bonn Airport to Palermo Airport via Rome
- Ave. Duration
- 4h
- When
- Monday, Tuesday, Thursday, Friday, and Sunday
- Estimated price
- €110–290
- Website
- swiss.com
Flights from Frankfurt to Palermo Airport via Zurich
- Ave. Duration
- 4h 25m
- When
- Thursday and Sunday
- Estimated price
- €75–300
Flights from Frankfurt to Catania–Fontanarossa Airport via Zurich
- Ave. Duration
- 4h 25m
- When
- Monday, Wednesday, Saturday, and Sunday
- Estimated price
- €190–440
- Website
- lufthansa.com
Flights from Frankfurt to Palermo Airport
- Ave. Duration
- 2h 15m
- When
- Saturday
- Estimated price
- €120–380
Flights from Frankfurt to Catania–Fontanarossa Airport
- Ave. Duration
- 2h 25m
- When
- Monday, Wednesday, Saturday, and Sunday
- Estimated price
- €170–340
Flights from Cologne Bonn Airport to Palermo Airport via Munich
- Ave. Duration
- 4h 15m
- When
- Sunday
- Estimated price
- €120–430
- Website
- eurowings.com
Flights from Cologne Bonn Airport to Palermo Airport
- Ave. Duration
- 2h 25m
- When
- Tuesday
- Estimated price
- €110–290
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- €13–19
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 53 min
- Frequency
- Twice daily
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 21m
- Frequency
- Hourly
- Estimated price
- €30–85
- Website
- https://int.bahn.de/en
Train from Frankfurt to Siegburg Bf
- Ave. Duration
- 51 min
- Frequency
- Hourly
- Estimated price
- €26–75
- Website
- https://int.bahn.de/en
- Phone
- +31 30 751 5155
- Website
- ns.nl
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 50m
- Frequency
- Twice daily
- Estimated price
- €40–140
- Website
- https://www.ns.nl/en
- 2nd Class
- €40–60
- 1st Class
- €80–140
Train from Mainz Hbf to Zürich HB
- Ave. Duration
- 6h 22m
- Frequency
- Twice daily
- Estimated price
- €70–240
- Website
- https://www.ns.nl/en
- 2nd Class
- €70–110
- 1st Class
- €140–240
- Phone
- +41 848 446 688
- Website
- sbb.ch
Train from Basel SBB to Zürich HB
- Ave. Duration
- 1h 12m
- Frequency
- Every 20 minutes
- Estimated price
- €21–45
- Website
- https://www.sbb.ch/en
Train from Zürich HB to Milan Rogoredo
- Ave. Duration
- 3h 40m
- Frequency
- Once daily
- Estimated price
- €75–140
- Website
- https://www.sbb.ch/en
Train from Zürich HB to Genova P. Principe
- Ave. Duration
- 6h 37m
- Frequency
- Once daily
- Estimated price
- €140–260
- Website
- https://www.sbb.ch/en
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Milan Rogoredo to Roma Termini
- Ave. Duration
- 2h 53m
- Frequency
- Hourly
- Estimated price
- €45–130
- Website
- https://www.italotreno.it/en
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Palermo Centrale
- Ave. Duration
- 11h 36m
- Frequency
- Once daily
- Estimated price
- €40–110
- Website
- https://www.trenitalia.com/en.html
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Mainz central train station to Milano, Autostazione Lampugnano
- Ave. Duration
- 12h 5m
- Frequency
- Twice daily
- Estimated price
- €40–110
- Website
- https://www.flixbus.co.uk
Bus from Milano, Autostazione Lampugnano to Palermo
- Ave. Duration
- 22h 5m
- Frequency
- Once daily
- Estimated price
- €50–170
- Website
- https://www.flixbus.co.uk
Bus from Catania Fontanarossa Airport Bus Stop to Palermo Via Tommaso Fazello
- Ave. Duration
- 3h 35m
- Frequency
- Twice daily
- Estimated price
- €11–18
- Website
- https://www.flixbus.co.uk
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Milano, Autostazione Lampugnano to Palermo
- Ave. Duration
- 21h 45m
- Frequency
- Twice a week
- Estimated price
- €50–75
- Schedules at
- autoservizisalemi.it
Bus from Milano, San Donato M3 to Palermo Via Tommaso Fazello
- Ave. Duration
- 21h
- Frequency
- Twice a week
- Estimated price
- €50–75
- Schedules at
- autoservizisalemi.it
- info@flibco.com
- Website
- flibco.com
Bus from Mainz Short-term parking lot Am Schlag to Frankfurt Hahn Airport
- Ave. Duration
- 1h 15m
- Frequency
- Every 2 hours
- Estimated price
- €17–20
- Website
- https://www.flibco.com/en
- Phone
- 800 21 10 20
- saisautolineeweb@gmail.com
- Website
- saisautolinee.it
Bus from Catania Fontanarossa Airport Bus Stop to Palermo Via Tommaso Fazello
- Ave. Duration
- 2h 30m
- Frequency
- Hourly
- Estimated price
- €11–16
- Schedules at
- saisautolinee.it
- Phone
- +39 080 3112335
- info@marinobus.it
- Website
- marinobus.it
Bus from Mannheim Central Bus Station to Milan
- Ave. Duration
- 12h 5m
- Frequency
- Twice a week
- Estimated price
- €40–65
- Website
- https://marinobus.it/en/
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Car ferry from Port of Genoa to Port of Palermo
- Ave. Duration
- 20h 45m
- Frequency
- Once daily
- Estimated price
- €60–130
- Website
- https://www.gnv.it/en
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More Questions & Answers
Mainz to Palermo bus services, operated by FlixBus, arrive at Milano, Autostazione Lampugnano station.
Mainz to Palermo train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Mannheim, Hauptbahnhof station.
Book your Mainz to Palermo train tickets online with Omio.
Book your Mainz to Palermo bus tickets online with Omio and FlixBus.
There are 5822+ hotels available in Palermo.


























































