There are 10 ways to get from Mainz to Palermo by plane, train (Trenitalia), car, car ferry, bus, train, or night train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Frankfurt to Palermo Airport
best- Fly from Frankfurt (FRA) to Palermo Airport (PMO)plane FRA - PMO
5h 41m€95–258Bus
cheapest- Take the bus from Mainz central train station to Milano, Autostazione Lampugnanobus 476
- Take the bus from Milano, Autostazione Lampugnano to Palermobus N597
35h€74–154Train via Basel
- Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
- Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain 20 / ...
- Take the train from Basel SBB to Domodossolatrain Ec
- Take the train from Domodossola to Milano Centraletrain
- Take the train from Milano Centrale to Roma Terminitrain Fr / ...
- Take the train from Roma Termini to Palermo Centraletrain Ic
26h 34m€176–501Drive, car ferry
- Drive from Mainz to Port of Genoacar
- Take the car ferry from Port of Genoa to Port of Palermocarferry
28h 27m€187–317Bus to Hahn, fly to Palermo Airport
- Take the bus from Mainz Short-term parking lot Am Schlag to Frankfurt Hahn Airportbus
- Fly from Hahn (HHN) to Palermo Airport (PMO)plane HHN - PMO
6h 37m€80–266Fly Frankfurt to Catania–Fontanarossa Airport, bus
- Fly from Frankfurt (FRA) to Catania–Fontanarossa Airport (CTA)plane FRA - CTA
- Take the bus from Catania Fontanarossa Airport Bus Stop to Palermo Via Tommaso Fazellobus
7h 55m€91–288Train to Cologne Bonn Airport, fly to Palermo Airport
- Take the train from Frankfurt to Siegburg Bftrain
- Fly from Cologne Bonn Airport (CGN) to Palermo Airport (PMO)plane CGN - PMO
7h 30m€103–420Train
- Take the train from Frankfurt to München Hbftrain 41 / ...
- Take the train from München Hbf to Verona Porta Nuovatrain 89
- Take the train from Verona Porta Nuova to Roma Terminitrain Fr
- Take the train from Roma Termini to Palermo Centraletrain Ic
27h 53m€173–541Train, night train
- Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
- Take the train from Mannheim, Hauptbahnhof to Hauptbahnhoftrain 22 / ...
- Take the night train from Stuttgart Hbf to Venezia Mestrenighttrain Nj
- Take the train from Venezia Mestre to Roma Terminitrain Fr
- Take the train from Roma Termini to Palermo Centraletrain Ic
32h 35m€145–562Train, bus
- Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
- Take the bus from Mannheim Central Bus Station to Milanbus
- Take the bus from Milano, San Donato M3 to Palermo Via Tommaso Fazellobus
36h 22m€104–170
Mainz to Palermo by train
Questions & Answers
The cheapest way to get from Mainz to Palermo is to bus which costs €70 - €160 and takes 35h.
The fastest way to get from Mainz to Palermo is to fly which takes 5h 41m and costs €95 - €260.
No, there is no direct bus from Mainz station to Palermo. However, there are services departing from Mainz central train station and arriving at Palermo via Milano, Autostazione Lampugnano. The journey, including transfers, takes approximately 35h.
No, there is no direct train from Mainz to Palermo. However, there are services departing from Mainz, Römisches Theater and arriving at Palermo Centrale via Mannheim, Hauptbahnhof, Basel SBB, Domodossola, Milano Centrale and Roma Termini. The journey, including transfers, takes approximately 26h 34m.
The distance between Mainz and Palermo is 1425 km.
The best way to get from Mainz to Palermo without a car is to train via Basel which takes 26h 34m and costs €170 - €500.
It takes approximately 5h 41m to get from Mainz to Palermo, including transfers.
Mainz to Palermo bus services, operated by FlixBus, depart from Mainz central train station.
Mainz to Palermo train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Römisches Theater station.
The best way to get from Mainz to Palermo is to fly which takes 5h 41m and costs €95 - €260. Alternatively, you can train via Basel, which costs €170 - €500 and takes 26h 34m, you could also bus, which costs €70 - €160 and takes 35h.
What companies run services between Mainz, Germany and Palermo, Italy?
Lufthansa, Air Dolomiti, and two other airlines fly from Frankfurt (FRA) to Palermo Airport (PMO) 4 times a day. Alternatively, you can take a train from Mainz, Römisches Theater to Palermo Centrale via Mannheim, Hauptbahnhof, Basel SBB, Domodossola, Milano Centrale, and Roma Termini in around 26h 34m.
- Website
- ita-airways.com
Flights from Frankfurt to Palermo Airport via Milan Linate
- Ave. Duration
- 4h 8m
- When
- Every day
- Estimated price
- €80–230
Flights from Frankfurt to Catania–Fontanarossa Airport
- Ave. Duration
- 2h 25m
- When
- Wednesday and Sunday
- Estimated price
- €75–300
Flights from Frankfurt to Catania–Fontanarossa Airport via Milan Linate
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- €65–240
- Website
- ryanair.com
Flights from Hahn to Palermo Airport
- Ave. Duration
- 2h 20m
- When
- Monday and Friday
- Estimated price
- €60–240
Flights from Hahn to Palermo Airport via Rome
- Ave. Duration
- 5h 2m
- When
- Monday, Friday, and Saturday
- Estimated price
- €60–240
Flights from Hahn to Palermo Airport via Bari
- Ave. Duration
- 5h 40m
- When
- Monday
- Estimated price
- €60–240
Flights from Cologne Bonn Airport to Palermo Airport
- Ave. Duration
- 2h 25m
- When
- Monday, Wednesday, Friday, and Saturday
- Estimated price
- €60–280
Flights from Cologne Bonn Airport to Palermo Airport via Bologna
- Ave. Duration
- 4h
- When
- Monday and Friday
- Estimated price
- €60–280
- Website
- lufthansa.com
Flights from Frankfurt to Palermo Airport
- Ave. Duration
- 2h 15m
- When
- Saturday
- Estimated price
- €150–270
Flights from Frankfurt to Catania–Fontanarossa Airport
- Ave. Duration
- 2h 25m
- When
- Wednesday and Sunday
- Estimated price
- €75–300
Flights from Cologne Bonn Airport to Palermo Airport via Munich
- Ave. Duration
- 4h 17m
- When
- Friday and Sunday
- Estimated price
- €85–380
- Website
- swiss.com
Flights from Frankfurt to Palermo Airport via Zurich
- Ave. Duration
- 4h 25m
- When
- Thursday and Sunday
- Estimated price
- €70–300
- Website
- eurowings.com
Flights from Cologne Bonn Airport to Palermo Airport
- Ave. Duration
- 2h 20m
- When
- Tuesday
- Estimated price
- €100–310
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- €13–19
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 53 min
- Frequency
- Once daily
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 21m
- Frequency
- Hourly
- Estimated price
- €27–65
- Website
- https://int.bahn.de/en
Train from Frankfurt to Siegburg Bf
- Ave. Duration
- 51 min
- Frequency
- Hourly
- Estimated price
- €20–60
- Website
- https://int.bahn.de/en
Train from Frankfurt to München Hbf
- Ave. Duration
- 3h 31m
- Frequency
- Every 30 minutes
- Estimated price
- €28–90
- Website
- https://int.bahn.de/en
Train from München Hbf to Verona Porta Nuova
- Ave. Duration
- 5h 31m
- Frequency
- Every 4 hours
- Estimated price
- €70–100
- Website
- https://int.bahn.de/en
Train from Mannheim, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 38 min
- Frequency
- Every 30 minutes
- Estimated price
- €18–40
- Website
- https://int.bahn.de/en
- Phone
- +31 30 751 5155
- Website
- ns.nl
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 50m
- Frequency
- Once daily
- Estimated price
- €40–140
- Website
- https://www.ns.nl/en
- 2nd Class
- €40–60
- 1st Class
- €80–140
Train from Frankfurt to Siegburg Bf
- Ave. Duration
- 39 min
- Frequency
- Every 3 hours
- Estimated price
- €23–75
- Website
- https://www.ns.nl/en
- 2nd Class
- €23–35
- 1st Class
- €45–75
Train from Frankfurt to München Hbf
- Ave. Duration
- 3h 19m
- Frequency
- 3 times a day
- Estimated price
- €60–220
- Website
- https://www.ns.nl/en
- 2nd Class
- €60–95
- 1st Class
- €130–220
Train from Mannheim, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 37 min
- Frequency
- 3 times a day
- Estimated price
- €18–60
- Website
- https://www.ns.nl/en
- 2nd Class
- €18–27
- 1st Class
- €30–60
- Phone
- +43 5 1717
- Website
- oebb.at
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 59m
- Frequency
- 6 times a week
- Estimated price
- €92–93
- Website
- https://www.oebb.at/en/reiseplanung-services/im-zug/unsere-zuege/eurocity-intercity
- Website
- https://shop.oebbtickets.at/en/ticket
- Phone
- +41 848 446 688
- Website
- sbb.ch
Train from Basel SBB to Domodossola
- Ave. Duration
- 2h 42m
- Frequency
- Once a week
- Estimated price
- €55–110
- Website
- https://www.sbb.ch/en
- Phone
- +39 02 7249 4494
- my-link@trenord.it
- Website
- trenord.it
Train from Domodossola to Milano Centrale
- Ave. Duration
- 1h 42m
- Frequency
- Every 2 hours
- Estimated price
- €8–11
- Website
- https://www.trenord.it/en/
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 12m
- Frequency
- Every 30 minutes
- Estimated price
- €45–110
- Schedules at
- trenitalia.com
Train from Verona Porta Nuova to Roma Termini
- Ave. Duration
- 3h 23m
- Frequency
- Every 4 hours
- Estimated price
- €40–100
- Schedules at
- trenitalia.com
Train from Venezia Mestre to Roma Termini
- Ave. Duration
- 3h 47m
- Frequency
- Hourly
- Estimated price
- €35–100
- Schedules at
- trenitalia.com
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 39m
- Frequency
- Hourly
- Estimated price
- €45–100
- Website
- https://www.italotreno.it/en
Train from Venezia Mestre to Roma Termini
- Ave. Duration
- 3h 48m
- Frequency
- Every 2 hours
- Estimated price
- €40–90
- Website
- https://www.italotreno.it/en
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Palermo Centrale
- Ave. Duration
- 11h 44m
- Frequency
- Once daily
- Estimated price
- €27–110
- Website
- https://www.trenitalia.com/en.html
Train from Venezia Mestre to Roma Termini
- Ave. Duration
- 7h 40m
- Frequency
- Twice daily
- Estimated price
- €19–60
- Website
- https://www.trenitalia.com/en.html
- Phone
- +33 1 84 94 36 35
- Website
- sncf-connect.com
Train from Mannheim, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 40 min
- Frequency
- 4 times a week
- Estimated price
- €25–60
- Website
- https://www.sncf-connect.com/en-en
- 2nd Class
- €25–35
- 1st Class
- €45–60
- Phone
- +43 51717
- Website
- nightjet.com
Night train from Stuttgart Hbf to Venezia Mestre
- Ave. Duration
- 11h 54m
- Frequency
- Once daily
- Estimated price
- €65–270
- Website
- https://www.nightjet.com/en/#/home
- Sleeper Carriage
- €260–270
- Couchette Carriage
- €150–180
- Seating Carriage
- €65–80
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Mainz central train station to Milano, Autostazione Lampugnano
- Ave. Duration
- 12h 5m
- Frequency
- Once daily
- Estimated price
- €35–65
- Website
- https://www.flixbus.co.uk
Bus from Milano, Autostazione Lampugnano to Palermo
- Ave. Duration
- 21h 55m
- Frequency
- Once daily
- Estimated price
- €35–90
- Website
- https://www.flixbus.co.uk
Bus from Catania Fontanarossa Airport Bus Stop to Palermo Via Tommaso Fazello
- Ave. Duration
- 2h 35m
- Frequency
- Twice daily
- Estimated price
- €9–16
- Website
- https://www.flixbus.co.uk
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Milano, Autostazione Lampugnano to Palermo
- Ave. Duration
- 21h 45m
- Frequency
- Twice a week
- Estimated price
- €60–90
- Schedules at
- autoservizisalemi.it
Bus from Milano, San Donato M3 to Palermo Via Tommaso Fazello
- Ave. Duration
- 21h
- Frequency
- Twice a week
- Estimated price
- €55–85
- Schedules at
- autoservizisalemi.it
- info@flibco.com
- Website
- flibco.com
Bus from Mainz Short-term parking lot Am Schlag to Frankfurt Hahn Airport
- Ave. Duration
- 1h 15m
- Frequency
- Every 2 hours
- Estimated price
- €17–20
- Website
- https://www.flibco.com/en
- Phone
- 800 21 10 20
- saisautolineeweb@gmail.com
- Website
- saisautolinee.it
Bus from Catania Fontanarossa Airport Bus Stop to Palermo Via Tommaso Fazello
- Ave. Duration
- 2h 30m
- Frequency
- Hourly
- Estimated price
- €11–16
- Schedules at
- saisautolinee.it
- Phone
- +39 080 3112335
- info@marinobus.it
- Website
- marinobus.it
Bus from Mannheim Central Bus Station to Milan
- Ave. Duration
- 12h 5m
- Frequency
- Twice a week
- Estimated price
- €35–65
- Website
- https://marinobus.it/en/
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Car ferry from Port of Genoa to Port of Palermo
- Ave. Duration
- 20h 45m
- Frequency
- Once daily
- Estimated price
- €65–140
- Website
- https://www.gnv.it/en
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More Questions & Answers
Mainz to Palermo bus services, operated by FlixBus, arrive at Milano, Autostazione Lampugnano station.
Mainz to Palermo train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Mannheim, Hauptbahnhof station.
Book your Mainz to Palermo train tickets online with Omio.
Book your Mainz to Palermo bus tickets online with Omio and FlixBus.
There are 5725+ hotels available in Palermo.

















































































