There are 9 ways to get from Mainz to Palermo by plane, train (Trenitalia), car, car ferry, bus, train, or night train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Frankfurt
best- Fly from Frankfurt (FRA) to Palermo Airport (PMO)plane FRA - PMO
5h 46m€96–279Bus to Hahn, fly
cheapest- Take the bus from Mainz Short-term parking lot Am Schlag to Frankfurt Hahn Airportbus
- Fly from Hahn (HHN) to Palermo Airport (PMO)plane HHN - PMO
6h 32m€71–242Train
- Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
- Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain 20 / ...
- Take the train from Basel SBB to Domodossolatrain Ec
- Take the train from Domodossola to Milano Centraletrain
- Take the train from Milano Centrale to Roma Terminitrain
- Take the train from Roma Termini to Palermo Centraletrain Ic
26h 32m€289–738Drive, car ferry
- Drive from Mainz to Port of Genoacar
- Take the car ferry from Port of Genoa to Port of Palermocarferry
28h 27m€218–327Bus
- Take the bus from Mainz central train station to Milanbus FlixBus 476
- Take the bus from Milano, Autostazione Lampugnano to Palermobus N597
35h€112–279Train to Cologne Bonn Airport, fly
- Take the train from Frankfurt to Siegburg Bftrain
- Fly from Cologne Bonn Airport (CGN) to Palermo Airport (PMO)plane CGN - PMO
7h 28m€99–358Train via Mainz, Römisches Theater
- Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
- Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain 20 / ...
- Take the train from Basel SBB to Domodossolatrain Ec
- Take the train from Domodossola to Milano Centraletrain
- Take the train from Milano Centrale to Roma Terminitrain Fr / ...
- Take the train from Roma Termini to Palermo Centraletrain Ic
26h 44m€289–748Train, night train
- Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
- Take the train from Mannheim, Hauptbahnhof to Hauptbahnhoftrain 22 / ...
- Take the night train from Stuttgart Hbf to Venezia Mestrenighttrain Nj
- Take the train from Venezia Mestre to Roma Terminitrain
- Take the train from Roma Termini to Palermo Centraletrain Ic
32h 31m€222–539Train, bus
- Take the train from Mainz Hbf to Zürich HBtrain
- Take the bus from Zurigo to Milanobus
- Take the bus from Milano, San Donato M3 to Palermo Via Tommaso Fazellobus
35h 31m€121–237
Mainz to Palermo by train
Questions & Answers
The cheapest way to get from Mainz to Palermo is to bus and fly which costs €70 - €250 and takes 6h 32m.
The fastest way to get from Mainz to Palermo is to fly which takes 5h 46m and costs €95 - €280.
No, there is no direct bus from Mainz station to Palermo. However, there are services departing from Mainz central train station and arriving at Palermo via Milano, Autostazione Lampugnano. The journey, including transfers, takes approximately 35h.
No, there is no direct train from Mainz to Palermo. However, there are services departing from Mainz, Römisches Theater and arriving at Palermo Centrale via Mannheim, Hauptbahnhof, Basel SBB, Domodossola, Milano Centrale and Roma Termini. The journey, including transfers, takes approximately 26h 32m.
The distance between Mainz and Palermo is 1425 km.
The best way to get from Mainz to Palermo without a car is to train which takes 26h 32m and costs €280 - €750.
It takes approximately 5h 46m to get from Mainz to Palermo, including transfers.
Mainz to Palermo bus services, operated by FlixBus, depart from Mainz central train station.
Mainz to Palermo train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Römisches Theater station.
The best way to get from Mainz to Palermo is to fly which takes 5h 46m and costs €95 - €280. Alternatively, you can train, which costs €280 - €750 and takes 26h 32m, you could also bus, which costs €110 - €280 and takes 35h.
What companies run services between Mainz, Germany and Palermo, Italy?
Lufthansa, ITA Airways, and Swiss fly from Frankfurt (FRA) to Palermo Airport (PMO) every 4 hours. Alternatively, you can take a train from Mainz, Römisches Theater to Palermo Centrale via Mannheim, Hauptbahnhof, Basel SBB, Domodossola, Milano Centrale, and Roma Termini in around 26h 32m.
- Website
- lufthansa.com
Flights from Frankfurt to Palermo Airport
- Ave. Duration
- 2h 20m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €80–340
Flights from Frankfurt to Palermo Airport via Munich
- Ave. Duration
- 3h 55m
- When
- Every day
- Estimated price
- €85–340
Flights from Cologne Bonn Airport to Palermo Airport via Munich
- Ave. Duration
- 4h 7m
- When
- Every day
- Estimated price
- €85–360
- Website
- ryanair.com
Flights from Hahn to Palermo Airport
- Ave. Duration
- 2h 15m
- When
- Tuesday, Wednesday, Thursday, and Sunday
- Estimated price
- €50–200
Flights from Cologne Bonn Airport to Palermo Airport
- Ave. Duration
- 2h 25m
- When
- Wednesday and Saturday
- Estimated price
- €70–250
Flights from Cologne Bonn Airport to Palermo Airport via Bologna
- Ave. Duration
- 5h 23m
- When
- Monday to Wednesday
- Estimated price
- €70–250
- Website
- swiss.com
Flights from Frankfurt to Palermo Airport via Zurich
- Ave. Duration
- 5h 27m
- When
- Every day
- Estimated price
- €75–310
Flights from Cologne Bonn Airport to Palermo Airport via Zurich
- Ave. Duration
- 4h 25m
- When
- Wednesday
- Estimated price
- €80–320
- Website
- ita-airways.com
Flights from Frankfurt to Palermo Airport via Milan Linate
- Ave. Duration
- 4h 22m
- When
- Every day
- Estimated price
- €80–260
- Website
- eurowings.com
Flights from Cologne Bonn Airport to Palermo Airport
- Ave. Duration
- 2h 20m
- When
- Tuesday and Saturday
- Estimated price
- €50–200
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- €19–27
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 53 min
- Frequency
- Once daily
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 21m
- Frequency
- Hourly
- Estimated price
- €45–110
- Website
- https://int.bahn.de/en
Train from Frankfurt to Siegburg Bf
- Ave. Duration
- 51 min
- Frequency
- Hourly
- Estimated price
- €27–65
- Website
- https://int.bahn.de/en
Train from Mannheim, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 38 min
- Frequency
- Every 30 minutes
- Estimated price
- €20–50
- Website
- https://int.bahn.de/en
- Phone
- +31 30 751 5155
- Website
- ns.nl
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 50m
- Frequency
- Once daily
- Estimated price
- €27–65
- Website
- https://www.ns.nl/en
Train from Frankfurt to Siegburg Bf
- Ave. Duration
- 39 min
- Frequency
- Every 3 hours
- Estimated price
- €15–40
- Website
- https://www.ns.nl/en
Train from Mannheim, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 37 min
- Frequency
- Twice daily
- Estimated price
- €11–28
- Website
- https://www.ns.nl/en
Train from Mainz Hbf to Zürich HB
- Ave. Duration
- 6h 22m
- Frequency
- Once daily
- Estimated price
- €45–120
- Website
- https://www.ns.nl/en
- Phone
- +43 5 1717
- Website
- oebb.at
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 11m
- Frequency
- 4 times a week
- Estimated price
- €55–95
- Website
- https://www.oebb.at/en/reiseplanung-services/im-zug/unsere-zuege/eurocity-intercity
- Website
- https://shop.oebbtickets.at/en/ticket
- Phone
- +41 848 446 688
- Website
- sbb.ch
Train from Basel SBB to Domodossola
- Ave. Duration
- 2h 42m
- Frequency
- Once a week
- Estimated price
- €80–240
- Website
- https://www.sbb.ch/en
- Phone
- +39 02 7249 4494
- my-link@trenord.it
- Website
- trenord.it
Train from Domodossola to Milano Centrale
- Ave. Duration
- 1h 42m
- Frequency
- Every 2 hours
- Estimated price
- €8–11
- Website
- https://www.trenord.it/en/
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 5m
- Frequency
- Every 30 minutes
- Estimated price
- €75–150
- Website
- https://www.italotreno.it/en
Train from Venezia Mestre to Roma Termini
- Ave. Duration
- 3h 45m
- Frequency
- Hourly
- Estimated price
- €65–130
- Website
- https://www.italotreno.it/en
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Palermo Centrale
- Ave. Duration
- 11h 44m
- Frequency
- Once daily
- Estimated price
- €85–200
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 12m
- Frequency
- Hourly
- Estimated price
- €80–160
- Schedules at
- trenitalia.com
- Phone
- +43 51717
- Website
- nightjet.com
Night train from Stuttgart Hbf to Venezia Mestre
- Ave. Duration
- 11h 54m
- Frequency
- Once daily
- Estimated price
- €45–130
- Website
- https://www.nightjet.com/en/#/home
- Sleeper Carriage
- €100–130
- Couchette Carriage
- €75–90
- Seating Carriage
- €45–55
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Mainz central train station to Milan
- Ave. Duration
- 12h 5m
- Frequency
- Once daily
- Estimated price
- €50–90
- Website
- https://www.flixbus.co.uk
Bus from Milano, Autostazione Lampugnano to Palermo
- Ave. Duration
- 21h 55m
- Frequency
- Once daily
- Estimated price
- €100–190
- Website
- https://www.flixbus.co.uk
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Milano, Autostazione Lampugnano to Palermo
- Ave. Duration
- 21h 45m
- Frequency
- Twice a week
- Estimated price
- €60–90
- Schedules at
- autoservizisalemi.it
Bus from Milano, San Donato M3 to Palermo Via Tommaso Fazello
- Ave. Duration
- 21h
- Frequency
- Twice a week
- Estimated price
- €55–85
- Schedules at
- autoservizisalemi.it
- info@flibco.com
- Website
- flibco.com
Bus from Mainz Short-term parking lot Am Schlag to Frankfurt Hahn Airport
- Ave. Duration
- 1h 15m
- Frequency
- Every 2 hours
- Estimated price
- €17–35
- Website
- https://www.flibco.com/en
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Zurigo to Milano
- Ave. Duration
- 6h
- Frequency
- Once daily
- Estimated price
- €17–35
- Website
- https://www.itabus.it/en/home
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Car ferry from Port of Genoa to Port of Palermo
- Ave. Duration
- 20h 45m
- Frequency
- Once daily
- Estimated price
- €95–150
- Website
- https://www.gnv.it/en
Want to know more about travelling around Italy
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More Questions & Answers
Mainz to Palermo bus services, operated by FlixBus, arrive at Milan station.
Mainz to Palermo train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Mannheim, Hauptbahnhof station.
Book your Mainz to Palermo train tickets online with Omio.
Book your Mainz to Palermo bus tickets online with Omio and FlixBus.
There are 5976+ hotels available in Palermo.








































































