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How to get fromMainz to Palermoby plane, train (Trenitalia), car, car ferry, bus, or train

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There are 10 ways to get from Mainz to Palermo by plane, train (Trenitalia), car, car ferry, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Frankfurt

    best
    1. Fly from Frankfurt (FRA) to Palermo Airport (PMO)plane plane FRA - PMO
    5h 37m
    €84–219

  2. Bus to Hahn, fly

    cheapest
    1. Take the bus from Mainz, Hauptbahnhof to Hahnbus bus
    2. Fly from Hahn (HHN) to Palermo Airport (PMO)plane plane HHN - PMO
    6h 23m
    €72–253

  3. Train

    1. Take the train from Mainz, Hauptbahnhof to Mannheim, Hauptbahnhoftrain train 55 / ...
    2. Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain train 12 / ...
    3. Take the train from Basel SBB to Luganotrain train Ec
    4. Take the train from Lugano to Milano Centraletrain train
    5. Take the train from Milano Centrale to Roma Terminitrain train
    6. Take the train from Roma Termini to Palermo Centraletrain train Ic
    25h 12m
    €243–950

  4. Drive, car ferry

    1. Drive from Mainz to Port of Genoacar car
    2. Take the carferry from Port of Genoa to Port of Palermocarferry car ferry
    28h 27m
    €224–339

  5. Bus

    1. Take the bus from Mühlheim am Main to Palermo Piazza Cairolibus bus
    32h 15m

  6. Train, train to Stuttgart Airport, fly

    1. Take the train from Mainz, Hauptbahnhof to Mannheim, Hauptbahnhoftrain train
    2. Take the train from Mannheim, Hauptbahnhof to Hauptbahnhoftrain train
    3. Fly from Stuttgart Airport (STR) to Palermo Airport (PMO)plane plane STR - PMO
    7h 7m
    €102–395

  7. Train to Cologne Bonn Airport, fly

    1. Take the train from Frankfurt to Siegburg Bftrain train
    2. Fly from Cologne Bonn Airport (CGN) to Palermo Airport (PMO)plane plane CGN - PMO
    7h 27m
    €92–462

  8. Train, car ferry

    1. Take the train from Mainz, Hauptbahnhof to Mannheim, Hauptbahnhoftrain train 55 / ...
    2. Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain train 12 / ...
    3. Take the train from Basel SBB to Zürich HBtrain train Tgv / ...
    4. Take the train from Zürich HB to Como S. Giovannitrain train Ec
    5. Take the train from Como S. Giovanni to Genova P. Principetrain train Ec
    6. Take the carferry from Port of Genoa to Port of Palermocarferry car ferry
    33h 56m
    €301–930

  9. Bus via Milan

    1. Take the bus from Mainz central train station to Milanbus bus FlixBus 476
    2. Take the bus from Milano, Autostazione Lampugnano to Palermobus bus N597
    35h
    €193–334

  10. Bus #2

    1. Take the bus from Wiesbaden Gartenfeldstraße P+R to Palermo Piazza Cairolibus bus
    38h 15m

Mainz to Palermo by bus

Calendar7Weekly Buses
Duration35hAverage Duration
Ticket€193Cheapest Price
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Questions & Answers

Map of how to get from Mainz to Palermo.ExpandLaunch map view
  • Distance: 1,424.6 km
  • Duration: 5h 37m

What companies run services between Mainz, Germany and Palermo, Italy?

Lufthansa, ITA Airways, and Swiss fly from Frankfurt (FRA) to Palermo Airport (PMO) every 4 hours. Alternatively, you can take a train from Mainz, Hauptbahnhof to Palermo Centrale via Mannheim, Hauptbahnhof, Basel SBB, Lugano, Milano Centrale, and Roma Termini in around 25h 12m.

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