Rome2Rio

Mainz to Madrid trains

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Trip Overview

The train between Mainz and Madrid takes 16h 28m. The train runs, on average, 6 times per week from Mainz to Madrid. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

16h 28m
Duration
2,427 km
Distance
€454
Average price
6 times a week
Frequency

Mainz to Madrid train times

Trains run 6 times a week between Mainz and Madrid. The service departs Mainz at 6:14 AM in the morning, which arrives into Madrid at 22:42:00. All services require a transfer at Frankfurt and take an average of 16h 28m. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

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    SüwexDeutsche Bahn Intercity (DB IC)TGV inOuiRenfe Viajerosiryo16h 28m • 4 changes

Departing Monday, November 16, 2026

  •  → 

    SüwexDeutsche Bahn Intercity (DB IC)TGV inOuiRenfe Viajerosiryo16h 28m • 4 changes

Departing Tuesday, November 17, 2026

  •  → 

    SüwexDeutsche Bahn Intercity (DB IC)TGV inOuiRenfe Viajerosiryo16h 28m • 4 changes

Departing Wednesday, November 18, 2026

  •  → 

    SüwexDeutsche Bahn Intercity (DB IC)TGV inOuiRenfe Viajerosiryo16h 28m • 4 changes

Departing Thursday, November 19, 2026

  •  → 

    SüwexDeutsche Bahn Intercity (DB IC)TGV inOuiRenfe Viajerosiryo16h 28m • 4 changes

Departing Friday, November 20, 2026

  •  → 

    SüwexDeutsche Bahn Intercity (DB IC)TGV inOuiRenfe Viajerosiryo16h 28m • 4 changes

Frequently asked questions

Want to know about travelling from Mainz to Madrid? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mainz to Madrid.ExpandLaunch map view
  • Distance: 2,427.4 km
  • Duration: 16h 28m

What companies run services between Mainz, Germany and Madrid, Spain?

You can take a train from Mainz, Römisches Theater to Madrid-Puerta de Atocha-Almudena Grandes via Frankfurt, Bruxelles Midi, Brussel-Zuid / Bruxelles-Midi, Lyon Part Dieu, and Barcelona-Sants in around 18h.

Operators