The average train between Mainz and Strasbourg takes 3h 28m and the fastest train takes 2h 20m. The train service runs several times per day from Mainz to Strasbourg. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Mainz and Strasbourg. The earliest departure is at 1:43 AM at night, and the last departure from Mainz is at 3:52 PM which arrives into Strasbourg at 6:48 PM. All services require a transfer, and take on average 3h 28m. The schedules shown below are for the next available departures.

3h 9m • 1 change

3h 29m • 1 change

3h 23m • 1 change

4h 2m • 1 change

2h 20m • 1 change

3h 36m • 1 change

3h 29m • 1 change

2h 24m • 1 change

7h 4m • 1 change

3h 38m • 1 change

3h 29m • 1 change

2h 20m • 1 change

3h 9m • 1 change

3h 29m • 1 change

3h 23m • 1 change

4h 2m • 1 change
Want to know about travelling from Mainz to Strasbourg? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Strasbourg. However, there are services departing from Mainz station and arriving at Strasbourg station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 3h 28m.
Mainz to Strasbourg train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Hauptbahnhof station.
Mainz to Strasbourg train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Strasbourg Bahnhof station.
Book your Mainz to Strasbourg train tickets online with Deutsche Bahn Regio (DB Regional), Deutsche Bahn Intercity (DB IC) and Nederlandse Spoorwegen (NS).
The distance between Mainz and Strasbourg is 160.4 km. The road distance is 212 km.
You can take a train from Mainz, Hauptbahnhof to Strasbourg Bahnhof via Mannheim, Hauptbahnhof in around 2h 48m.