The average train between Mainz and Karlsruhe takes 1h 45m and the fastest train takes 1h 13m. There is a train service every few hours from Mainz to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mainz and Karlsruhe. The earliest departure is at 1:43 AM at night, and the last departure from Mainz is at 9:17 PM which arrives into Karlsruhe at 10:59 PM. All services require a transfer, and take on average 1h 45m. The schedules shown below are for the next available departures.

1h 46m • 1 change

1h 17m • 1 change

1h 42m • 1 change

1h 16m • 1 change

3h 39m • 1 change

1h 17m • 1 change

1h 59m • 1 change

2h 7m • 1 change

2h 4m • 1 change

2h 40m • 1 change

2h 20m • 1 change

1h 54m • 1 change
Want to know about travelling from Mainz to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Karlsruhe. However, there are services departing from Mainz station and arriving at Karlsruhe station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 1h 45m.
Mainz to Karlsruhe train services, operated by Süwex, depart from Mainz, Hauptbahnhof station.
Mainz to Karlsruhe train services, operated by Süwex, arrive at Karlsruhe Hauptbahnhof station.
Book your Mainz to Karlsruhe train tickets online with Süwex, Deutsche Bahn Intercity (DB IC) and 2 other operators.
The distance between Mainz and Karlsruhe is 108.8 km. The road distance is 130 km.
You can take a train from Mainz, Hauptbahnhof to Karlsruhe Hauptbahnhof via Mannheim, Hauptbahnhof in around 1h 10m.