The average train between Mendrisio and Spoleto takes 8h 14m and the fastest train takes 6h 28m. The train service runs several times per day from Mendrisio to Spoleto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Mendrisio and Spoleto. The earliest departure is at 6:18 AM in the morning, and the last departure from Mendrisio is at 9:18 PM which arrives into Spoleto at 11:02 AM. All services require a transfer at Milano Centrale and take an average of 8h 14m. The schedules shown below are for the next available departures.


6h 30m • 2 changes
Arrives next day


12h 58m • 2 changes
Arrives next day


13h 44m • 2 changes


7h 33m • 2 changes


6h 37m • 2 changes


6h 37m • 2 changes


6h 28m • 2 changes


7h 33m • 2 changes


6h 37m • 2 changes


6h 37m • 2 changes


6h 28m • 2 changes


7h 33m • 2 changes


6h 37m • 2 changes


6h 37m • 2 changes


6h 28m • 2 changes


7h 33m • 2 changes


6h 37m • 2 changes


6h 37m • 2 changes


6h 28m • 2 changes


6h 45m • 2 changes


6h 37m • 2 changes


6h 37m • 2 changes


6h 28m • 2 changes
Want to know about travelling from Mendrisio to Spoleto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mendrisio to Spoleto. However, there are services departing from Mendrisio station and arriving at Spoleto station via Milano Centrale. The journey, including transfers, takes approximately 8h 14m.
Mendrisio to Spoleto train services, operated by Swiss Federal Railways (SBB CFF FFS), depart from Mendrisio station.
Mendrisio to Spoleto train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Spoleto station.
The distance between Mendrisio and Spoleto is 458.4 km. The road distance is 735 km.
You can take a train from Mendrisio to Spoleto via Milano Centrale and Roma Tiburtina in around 6h 37m.