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How to get fromIsernia to Palermoby train, plane, car, ferry, bus, train (Trenitalia) or shuttle

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There are 7 ways to get from Isernia to Palermo by train, plane, car, ferry, bus, train (Trenitalia), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Naples Airport, fly to Palermo Airport

    best
    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Palermo Airport (PMO)plane plane NAP - PMO
    5h 32m
    €37–130

  2. Bus

    cheapest
    1. Take the bus from Isernia to Caserta Terminal Busbus bus 433
    2. Take the bus from Caserta Viale Vittorio Veneto to Palermo Via Tommaso Fazellobus bus Autoservizi Salemi S201
    12h
    €35–55

  3. Drive, ferry

    1. Drive from Isernia to Naples Beverellocar car
    2. Take the ferry from Naples Beverello to Port of Palermoferry ferry
    10h 2m
    €43–75

  4. Train (Trenitalia)

    1. Take the train from Isernia to Cassinotrain train Re
    2. Take the train from Cassino to Palermo Centraletrain train Ic
    12h 47m
    €81–181

  5. Train to Fiumicino International Airport, fly to Palermo Airport

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Palermo Airport (PMO)plane plane FCO - PMO
    6h 14m
    €60–183

  6. Train to Fiumicino International Airport, fly to Trapani Airport, shuttle

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Trapani Airport (TPS)plane plane FCO - TPS
    3. Take a shuttle bus from Trapani Birgi Airport to Lazio Municipioshuttle bus
    7h 55m
    €79–291

  7. Bus, ferry

    1. Take the bus from Isernia to Napoli P.zza Garibaldibus bus 433
    2. Take the ferry from Naples Beverello to Port of Palermoferry ferry
    11h 58m
    €35–65

Isernia to Palermo by bus

Calendar7Weekly Buses
Duration12hAverage Duration
Ticket€35Cheapest Price
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Questions & Answers

What companies run services between Isernia, Italy and Palermo, Italy?

You can take a bus from Isernia to Palermo Via Tommaso Fazello via Caserta Terminal Bus and Caserta Viale Vittorio Veneto in around 12h. Alternatively, you can take a train from Isernia to Palermo Centrale via Cassino in around 12h 47m.

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