The average train between Genoa and Isernia takes 10h 23m and the fastest train takes 7h 43m. The train service runs several times per day from Genoa to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Genoa and Isernia. The earliest departure is at 6:57 AM in the morning, and the last departure from Genoa is at 6:42 PM which arrives into Isernia at 8:27 AM. All services require a transfer, and take on average 10h 23m. The schedules shown below are for the next available departures.

8h 11m • 1 change

9h 53m • 1 change
Arrives next day

13h 45m • 1 change

8h 11m • 1 change

9h 53m • 1 change
Arrives next day

13h 45m • 1 change

8h 11m • 1 change

9h 53m • 1 change
Arrives next day

13h 45m • 1 change

8h 11m • 1 change

9h 53m • 1 change
Arrives next day

13h 45m • 1 change
Want to know about travelling from Genoa to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Genoa to Isernia. However, there are services departing from Genoa station and arriving at Isernia station via Roma Termini. The journey, including transfers, takes approximately 10h 23m.
Genoa to Isernia train services, operated by Trenitalia Intercity, depart from Genova Brignole station.
Genoa to Isernia train services, operated by Trenitalia Intercity, arrive at Isernia station.
Book your Genoa to Isernia train tickets online with Trenitalia Intercity, Trenitalia and Trenitalia Frecce.
The distance between Genoa and Isernia is 531.4 km. The road distance is 674 km.
You can take a train from Genova Brignole to Isernia via Roma Termini in around 7h 56m.