The average bus between St. Louis and Chicago takes 6h 28m and the fastest bus takes 6h 5m. The bus service runs several times per day from St. Louis to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between St. Louis and Chicago. The earliest departure is at 9:30 AM in the morning, and the last departure from St. Louis is at 11:30 PM which arrives into Chicago at 5:45 AM. All services run direct with no transfers required, and take on average 6h 28m. The schedules shown below are for the next available departures.
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Want to know about travelling from St. Louis to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
Yes, there is a direct bus departing from St. Louis station and arriving at Chicago station. Services depart 3 times a day, and operate Once daily. The journey takes approximately 6h 28m.
St. Louis to Chicago bus services, operated by Flixbus USA, depart from St Louis Bus Station.
St. Louis to Chicago bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
Book your St. Louis to Chicago bus tickets online with Flixbus USA.
The distance between St. Louis and Chicago is 421.9 km. The road distance is 516 km.
Flixbus USA operates a bus from St Louis Bus Station to Chicago Bus Station 3 times a day. Tickets cost $40–70 and the journey takes 6h 15m.
