Rome2Rio

Des Moines to Chicago buses

Find Transport to Chicago

View schedule
QR code to download the Rome2Rio app

Download the Rome2Rio travel app

Scan QR code with your phone to download the app

Download on the App StoreGet it on Google Play

Trip Overview

The average bus between Des Moines and Chicago takes 8h 13m and the fastest bus takes 7h 5m. The bus service runs several times per day from Des Moines to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

8h 13m
Duration
339 mi
Distance
$70
Average price
3 times a day
Frequency

Des Moines to Chicago bus times

Buses run 3 times a day between Des Moines and Chicago. The earliest departure is at 5:30 AM in the morning, and the last departure from Des Moines is at 9:45 AM which arrives into Chicago at 7:45 PM. All services run direct with no transfers required, and take on average 8h 13m. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

  •  → 

    bus bus 8h 5m • Direct
  •  → 

    bus bus 7h 5m • Direct
  •  → 

    bus bus 10h • Direct

Departing Monday, November 16, 2026

  •  → 

    bus bus 8h 5m • Direct
  •  → 

    bus bus 7h 5m • Direct
  •  → 

    bus bus 10h • Direct

Departing Tuesday, November 17, 2026

  •  → 

    bus bus 8h 5m • Direct
  •  → 

    bus bus 7h 5m • Direct

Departing Wednesday, November 18, 2026

  •  → 

    bus bus 8h 5m • Direct
  •  → 

    bus bus 7h 5m • Direct

Departing Thursday, November 19, 2026

  •  → 

    bus bus 8h 5m • Direct
  •  → 

    bus bus 7h 5m • Direct
  •  → 

    bus bus 10h • Direct

Departing Friday, November 20, 2026

  •  → 

    bus bus 8h 5m • Direct
  •  → 

    bus bus 7h 5m • Direct
  •  → 

    bus bus 10h • Direct

Departing Saturday, November 21, 2026

  •  → 

    bus bus 8h 5m • Direct
  •  → 

    bus bus 7h 5m • Direct
  •  → 

    bus bus 10h • Direct

Frequently asked questions

Want to know about travelling from Des Moines to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to Chicago.ExpandLaunch map view
  • Distance: 339.1 mi
  • Duration: 8h 13m

What companies run services between Des Moines, IA, USA and Chicago, IL, USA?

Greyhound USA operates a bus from Des Moines to Chicago Bus Station 3 times a day. Tickets cost $60–90 and the journey takes 7h 5m.

Operators