Rome2Rio

Depew to Boston buses

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Trip Overview

The average bus between Depew and Boston takes 13h 4m and the fastest bus takes 11h 9m. The bus runs, on average, 6 times per week from Depew to Boston. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

13h 4m
Duration
487 mi
Distance
$102
Average price
6 times a week
Frequency

Depew to Boston bus times

Buses run 6 times a week between Depew and Boston. The earliest departure is at 7:15 AM in the morning, and the last departure from Depew is at 7:43 PM which arrives into Boston at 6:25 PM. All services require a transfer, and take on average 13h 4m. The schedules shown below are for the next available departures.

Departing Monday, November 16, 2026

  •  → 

    NFTAGreyhound USA11h 9m • 1 change

Departing Tuesday, November 17, 2026

  •  → 

    NFTAGreyhound USA11h 9m • 1 change

Departing Wednesday, November 18, 2026

  •  → 

    NFTAGreyhound USA11h 9m • 1 change

Departing Thursday, November 19, 2026

  •  → 

    NFTAGreyhound USA11h 9m • 1 change

Departing Friday, November 20, 2026

  •  → 

    NFTAGreyhound USA11h 9m • 1 change
  •  → 

    Arrives next day

    NFTAGreyhound USA22h 41m • 1 change

Frequently asked questions

Want to know about travelling from Depew to Boston? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Depew to Boston.ExpandLaunch map view
  • Distance: 486.7 mi
  • Duration: 13h 4m

What companies run services between Depew, NY, USA and Boston, MA, USA?

Greyhound USA operates a bus from Buffalo to Boston once daily. Tickets cost $80–130 and the journey takes 10h 5m.

Operators