The average bus between Boston and Chicago takes 25h 52m and the fastest bus takes 21h 10m. The bus service runs several times per day from Boston to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Boston and Chicago. The earliest departure is at 1:30 AM at night, and the last departure from Boston is at 5:15 PM which arrives into Chicago at 1:25 PM. All services require a transfer, and take on average 25h 52m. The schedules shown below are for the next available departures.
Arrives next day

24h 10m • 1 change
Arrives next day

20h 10m • 1 change
Arrives next day

28h 40m • 1 change
Arrives next day

22h 20m • 1 change
Arrives next day

28h 40m • 1 change
Arrives next day

20h 10m • 1 change
Arrives next day

28h 40m • 1 change
Arrives next day

20h 10m • 1 change
Want to know about travelling from Boston to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Boston to Chicago. However, there are services departing from Boston station and arriving at Chicago station via Newark Penn Station station. The journey, including transfers, takes approximately 25h 52m.
Boston to Chicago bus services, operated by Greyhound USA, depart from Boston station.
Boston to Chicago bus services, operated by Greyhound USA, arrive at Chicago Bus Station.
Book your Boston to Chicago bus tickets online with Greyhound USA and Flixbus USA.
The distance between Boston and Chicago is 1,365.4 km. The road distance is 1,747 km.
You can take a bus from Boston to Chicago Bus Station via Newark Penn Station in around 22h 10m.