The average bus between Depew and Rochester takes 2h 57m and the fastest bus takes 2h 21m. The bus service runs several times per day from Depew to Rochester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Depew and Rochester. The earliest departure is at 5:53 AM in the morning, and the last departure from Depew is at 7:43 PM which arrives into Rochester at 10:05 PM. All services require a transfer, and take on average 2h 57m. The schedules shown below are for the next available departures.

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Want to know about travelling from Depew to Rochester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Depew to Rochester. However, there are services departing from Depew station and arriving at Rochester station via Ellicott Street & MTC Static. The journey, including transfers, takes approximately 2h 57m.
Depew to Rochester bus services, operated by NFTA, depart from Broadway & Meridian Street station.
Depew to Rochester bus services, operated by NFTA, arrive at Rochester Bus Stop station.
The distance between Depew and Rochester is 91.9 km. The road distance is 149 km.
You can take a bus from Broadway & Meridian Street to Rochester Bus Stop via Buffalo in around 3h 21m.