The average bus between Depew and Manhattan takes 9h 58m and the fastest bus takes 9h 6m. The bus service runs several times per day from Depew to Manhattan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Depew and Manhattan. The earliest departure is at 1:19 PM in the afternoon, and the last departure from Depew is at 7:43 PM which arrives into Manhattan at 4:50 AM. All services require a transfer, and take on average 9h 58m. The schedules shown below are for the next available departures.

10h 5m • 1 change
Arrives next day

10h 34m • 1 change
Arrives next day

9h 6m • 1 change

10h 5m • 1 change
Arrives next day

10h 34m • 1 change
Arrives next day

9h 6m • 1 change

10h 5m • 1 change
Arrives next day

10h 34m • 1 change
Arrives next day

9h 6m • 1 change
Want to know about travelling from Depew to Manhattan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Depew to Manhattan. However, there are services departing from Depew station and arriving at Manhattan station via Port Authority Bus Terminal. The journey, including transfers, takes approximately 9h 58m.
Depew to Manhattan bus services, operated by NFTA, depart from Buffalo station.
Depew to Manhattan bus services, operated by NFTA, arrive at Port Authority Bus Terminal station.
The distance between Depew and Manhattan is 456.9 km. The road distance is 700 km.
Greyhound USA operates a bus from Buffalo to Port Authority Bus Terminal 4 times a day. Tickets cost $60–120 and the journey takes 8h 5m. Trailways also services this route 3 times a day.