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How to get fromDepew to Bostonby plane, train, bus (Greyhound), train (Amtrak), car, ferry, or bus (Flixbus)

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There are 6 ways to get from Depew to Boston by plane, train, bus (Greyhound), train (Amtrak), car, ferry, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Laguardia Airport, train

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Laguardia Airport (LGA)plane plane BUF - LGA
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Bostontrain train
    6h 45m
    $150–646

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Buffalo to Bostonbus bus Greyhound US0171
    12h 4m
    $77–122

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Bostontrain train Lake Shore Limited
    12h 33m
    $122–312

  4. Drive  443 mi

    1. Drive from Depew to Bostoncar car 443 mi
    7h 54m
    $81–117

  5. Fly to Provincetown Municipal Airport, ferry

    1. Fly from Buffalo Niagara International Airport (BUF) to Provincetown Municipal Airport (PVC)plane plane BUF - PVC
    2. Take the ferry from MacMillan Pier, Provincetown, MA to World Trade Center Pier, Boston, MAferry ferry
    6h 26m
    $168–540

  6. Bus via Ithaca (Flixbus)

    1. Take the bus from Buffalo to Ithacabus bus FlixBus 2685 / ...
    2. Take the bus from Ithaca to Bostonbus bus FlixBus 2691
    14h 39m
    $81–132

Depew to Boston by bus (Greyhound)

Calendar7Weekly Buses
Duration12h 4mAverage Duration
Ticket$77Cheapest Price
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Comparing Your Travel Options

Map of how to get from Depew to Boston.ExpandLaunch map view
  • Distance: 536.1 mi
  • Duration: 6h 45m

What companies run services between Depew, NY, USA and Boston, MA, USA?

Greyhound USA operates a bus from Buffalo to Boston once daily. Tickets cost $75–120 and the journey takes 10h 5m. Alternatively, Amtrak operates a train from Buffalo Depew Station to Boston once daily. Tickets cost $120–310 and the journey takes 11h 27m.

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