There are 5 ways to get from Siena to Isernia by bus, train, car, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Siena, Stazione FS to Cassinobus
- Take the bus from Cassino Piazza Garibaldi to Iserniabus Cb 015
5h 44m€4–6Train
- Take the train from Siena to Firenze S.M.N.train Re
- Take the train from Florence Santa Maria Novella to Roma Terminitrain
- Take the train from Roma Termini to Iserniatrain Re
6h 41m€41–82Drive 384.9 km
- Drive from Siena to Iserniacar 384.9 km
3h 48m€60–86Bus via Rome
- Take the bus from Siena to Roma, Autostazione Tiburtinabus 1520 / ...
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
6h€15–68Train via Chiusi
- Take the train from Siena to Chiusi-Chianciano T.train Re
- Take the train from Chiusi-Chianciano T. to Roma Terminitrain Re
- Take the train from Roma Termini to Iserniatrain Re
7h 40m€27–48
Siena to Isernia by train
Questions & Answers
The cheapest way to get from Siena to Isernia is to bus which costs €3 - €6 and takes 5h 44m.
The fastest way to get from Siena to Isernia is to drive which takes 3h 48m and costs €55 - €90.
No, there is no direct bus from Siena to Isernia. However, there are services departing from Siena, Stazione FS and arriving at Isernia via Cassino Piazza Garibaldi. The journey, including transfers, takes approximately 5h 44m.
No, there is no direct train from Siena to Isernia. However, there are services departing from Siena and arriving at Isernia via Florence Santa Maria Novella and Roma Termini. The journey, including transfers, takes approximately 6h 41m.
The distance between Siena and Isernia is 391 km. The road distance is 384.9 km.
The best way to get from Siena to Isernia without a car is to bus which takes 5h 44m and costs €3 - €6.
It takes approximately 5h 44m to get from Siena to Isernia, including transfers.
Siena to Isernia bus services, operated by FlixBus, depart from Siena station.
Siena to Isernia train services, operated by Trenitalia S.p.A., depart from Siena station.
The best way to get from Siena to Isernia is to bus which takes 5h 44m and costs €3 - €6. Alternatively, you can train, which costs €40 - €85 and takes 6h 41m.
What companies run services between Siena, Italy and Isernia, Italy?
You can take a bus from Siena, Stazione FS to Isernia via Cassino and Cassino Piazza Garibaldi in around 5h 44m. Alternatively, you can take a train from Siena to Isernia via Florence Santa Maria Novella and Roma Termini in around 6h 41m.
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Siena to Firenze S.M.N.
- Ave. Duration
- 1h 34m
- Frequency
- Hourly
- Estimated price
- €7–10
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
Train from Siena to Chiusi-Chianciano T.
- Ave. Duration
- 1h 28m
- Frequency
- Every 2 hours
- Estimated price
- €6–10
- Website
- https://www.trenitalia.com/en.html
Train from Chiusi-Chianciano T. to Roma Termini
- Ave. Duration
- 2h 4m
- Frequency
- Every 4 hours
- Estimated price
- €9–15
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Florence Santa Maria Novella to Roma Termini
- Ave. Duration
- 1h 32m
- Frequency
- Hourly
- Estimated price
- €23–55
- Website
- https://www.italotreno.it/en
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Chiusi-Chianciano T. to Roma Termini
- Ave. Duration
- 2h 30m
- Frequency
- 3 times a day
- Estimated price
- €11–21
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 089 233 899
- salerno@autolineecurcio.it
- Website
- autolineecurcio.it
Bus from Siena, Stazione FS to Cassino
- Ave. Duration
- 3h 40m
- Frequency
- Once daily
- Estimated price
- €2
- Website
- https://www.autolineecurcio.it/
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Cassino Piazza Garibaldi to Isernia
- Ave. Duration
- 58 min
- Frequency
- 3 times a day
- Estimated price
- €2–4
- Schedules at
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Siena to Roma, Autostazione Tiburtina
- Ave. Duration
- 2h 50m
- Frequency
- Every 3 hours
- Estimated price
- €8–35
- Website
- https://www.flixbus.co.uk
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- €12–35
- Website
- https://www.flixbus.co.uk
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Siena to Roma, Autostazione Tiburtina
- Ave. Duration
- 2h 50m
- Frequency
- 5 times a day
- Estimated price
- €7–30
- Website
- https://www.itabus.it/en/home
- Phone
- +39 080 3112335
- info@marinobus.it
- Website
- marinobus.it
Bus from Siena to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 10m
- Frequency
- Twice daily
- Estimated price
- €13–35
- Website
- https://marinobus.it/en/
- Phone
- +39 0972 24590
- booking@autolineemoretti.it
- Website
- autolineemoretti.it
Bus from Siena to Roma, Autostazione Tiburtina
- Ave. Duration
- 4h 5m
- Frequency
- 3 times a week
- Estimated price
- €16–18
- Schedules at
- autolineemoretti.it
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More Questions & Answers
Siena to Isernia bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Siena to Isernia train services, operated by Trenitalia S.p.A., arrive at Firenze S.M.N. station.
Yes, the driving distance between Siena to Isernia is 385 km. It takes approximately 3h 48m to drive from Siena to Isernia.
Book your Siena to Isernia bus tickets online with Omio and FlixBus.
There are 420+ hotels available in Isernia.