Rome2Rio

How to get fromSiena to Iserniaby bus, train, train (Trenitalia), or car

Find Transport to Isernia

See all options

There are 5 ways to get from Siena to Isernia by bus, train, train (Trenitalia), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train

    best
    1. Take the bus from Siena, Stazione FS to Cassinobus bus
    2. Take the train from Cassino to Iserniatrain train Re
    5h 34m
    €29–43

  2. Bus

    cheapest
    1. Take the bus from Siena to Roma, Autostazione Tiburtinabus bus 1520 / ...
    2. Take the bus from Roma, Autostazione Tiburtina to Iserniabus bus Rome Tiburtina
    6h
    €24–55

  3. Train (Trenitalia)

    1. Take the train from Siena to Firenze S.M.N.train train Re
    2. Take the train from Firenze S.M.N. to Roma Terminitrain train Fr
    3. Take the train from Roma Termini to Iserniatrain train Re
    6h 34m
    €63–139

  4. Drive 384.9 km

    1. Drive from Siena to Iserniacar car 384.9 km
    3h 51m
    €61–88

  5. Train via Chiusi (Trenitalia)

    1. Take the train from Siena to Chiusi-Chianciano T.train train Re
    2. Take the train from Chiusi-Chianciano T. to Roma Terminitrain train Re
    3. Take the train from Roma Termini to Iserniatrain train Re
    7h 23m
    €50–93

Siena to Isernia by bus, foot, and train

Calendar7Weekly Services
Duration5h 34mAverage Duration
Ticket€29Cheapest Price
See schedules

Questions & Answers

Map of how to get from Siena to Isernia.ExpandLaunch map view
  • Distance: 393.4 km
  • Duration: 5h 34m

What companies run services between Siena, Italy and Isernia, Italy?

You can take a train from Siena to Isernia via Firenze S.M.N. and Roma Termini in around 6h 34m. Alternatively, you can take a bus from Siena to Isernia via Roma, Autostazione Tiburtina in around 6h.

Train operators
Bus operators

Want to know more about travelling around Italy

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Italy Travel Guides

Read the travel guideItaly Travel Guides

More Questions & Answers