There are 5 ways to get from Assisi to Isernia by bus, train (Trenitalia), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via Rome
best- Take the bus from Assisi - Piazza San Pietro to Roma, Autostazione Tiburtinabus
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
6h 20m€31–48Bus
cheapest- Take the bus from Assisi to Pescarabus 443
- Take the bus from Chieti to Iserniabus 433
9h 1m€22–76Train (Trenitalia)
- Take the train from Foligno to Roma Terminitrain 4153 / ...
- Take the train from Roma Termini to Iserniatrain Re
6h 41m€23–76Drive 286.3 km
- Drive from Assisi to Iserniacar 286.3 km
4h 13m€45–64Train via Assisi (Trenitalia)
- Take the train from Foligno to Roma Tiburtinatrain 4153 / ...
- Take the train from Roma Tiburtina to Iserniatrain Re
6h 51m€28–51
Assisi to Isernia by bus
Questions & Answers
The cheapest way to get from Assisi to Isernia is to bus via Rome which costs €30 - €50 and takes 6h 20m.
The fastest way to get from Assisi to Isernia is to drive which takes 4h 13m and costs €40 - €65.
No, there is no direct bus from Assisi to Isernia. However, there are services departing from Assisi - Piazza San Pietro and arriving at Isernia via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 6h 20m.
The distance between Assisi and Isernia is 371 km. The road distance is 286.3 km.
The best way to get from Assisi to Isernia without a car is to bus via Rome which takes 6h 20m and costs €30 - €50.
It takes approximately 6h 20m to get from Assisi to Isernia, including transfers.
Assisi to Isernia bus services, operated by Sulga Autolinee, depart from Assisi - Piazza San Pietro station.
The best way to get from Assisi to Isernia is to bus via Rome which takes 6h 20m and costs €30 - €50. Alternatively, you can train, which costs €23 - €80 and takes 6h 41m.
Assisi to Isernia bus services, operated by Sulga Autolinee, arrive at Roma, Autostazione Tiburtina station.
Yes, the driving distance between Assisi to Isernia is 286 km. It takes approximately 4h 13m to drive from Assisi to Isernia.
What companies run services between Assisi, Italy and Isernia, Italy?
You can take a bus from Assisi - Piazza San Pietro to Isernia via Roma, Autostazione Tiburtina in around 6h 20m. Alternatively, you can take a bus from P.za Matteotti Assisi to Isernia via Foligno - Stazione, Foligno, and Roma Termini in around 6h 41m.
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Foligno to Roma Termini
- Ave. Duration
- 1h 55m
- Frequency
- Every 2 hours
- Estimated price
- €12–25
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
Train from Foligno to Roma Tiburtina
- Ave. Duration
- 1h 43m
- Frequency
- Every 2 hours
- Estimated price
- €12–26
- Website
- https://www.trenitalia.com/en.html
Train from Roma Tiburtina to Isernia
- Ave. Duration
- 2h 14m
- Frequency
- 6 times a week
- Estimated price
- €14
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Foligno to Roma Termini
- Ave. Duration
- 2h 5m
- Frequency
- 3 times a day
- Estimated price
- €9–21
- Website
- https://www.trenitalia.com/en.html
Train from Foligno to Roma Tiburtina
- Ave. Duration
- 1h 48m
- Frequency
- 3 times a day
- Estimated price
- €9–21
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Foligno to Roma Termini
- Ave. Duration
- 1h 39m
- Frequency
- Once daily
- Estimated price
- €14–55
- Schedules at
- trenitalia.com
- Super Economy
- €14–20
- Base Standard
- €30–45
- Base Premium
- €35–55
- Phone
- +39 075 5009641
- info@sulga.it
- Website
- sulga.it
Bus from Assisi - Piazza San Pietro to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 10m
- Frequency
- 6 times a week
- Estimated price
- €23–26
- Schedules at
- sulga.it
- 2nd Class
- €23–26
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- €8–22
- Website
- https://www.flixbus.co.uk
Bus from Assisi to Pescara
- Ave. Duration
- 3h 50m
- Frequency
- Once daily
- Estimated price
- €11–24
- Website
- https://www.flixbus.co.uk
Bus from Chieti to Isernia
- Ave. Duration
- 2h 9m
- Frequency
- Twice daily
- Estimated price
- €8–35
- Website
- https://www.flixbus.co.uk
Want to know more about travelling around Italy
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
Want to know more about Flixbus?
Read the travel guide
More Questions & Answers
Book your Assisi to Isernia bus tickets online with Omio.
There are 357+ hotels available in Isernia.