There are 5 ways to get from Assisi to Isernia by bus, train (Trenitalia), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via Rome
best- Take the bus from Assisi - Piazza San Pietro to Roma, Autostazione Tiburtinabus
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
6h 20m€31–49Train (Trenitalia)
- Take the train from Assisi to Roma Tiburtinatrain 4735 / ...
- Take the train from Roma Tiburtina to Iserniatrain Re
6h 59m€41–67Drive 286.2 km
- Drive from Assisi to Iserniacar 286.2 km
4h 13m€52–75Train via Foligno - Stazione (Trenitalia)
- Take the train from Foligno to Roma Terminitrain 4155 / ...
- Take the train from Roma Termini to Iserniatrain Re
7h 2m€41–74Bus
- Take the bus from Assisi to Pescarabus 443
- Take the bus from Chieti to Iserniabus 433 / ...
9h 24m€34–60
Assisi to Isernia by bus
Comparing Your Travel Options
The cheapest way to get from Assisi to Isernia is to bus via Rome which costs €30 - €50 and takes 6h 20m.
The fastest way to get from Assisi to Isernia is to drive which takes 4h 13m and costs €50 - €75.
No, there is no direct bus from Assisi to Isernia. However, there are services departing from Assisi - Piazza San Pietro and arriving at Isernia via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 6h 20m.
No, there is no direct train from Assisi to Isernia. However, there are services departing from Assisi and arriving at Isernia via Roma Tiburtina. The journey, including transfers, takes approximately 6h 59m.
The distance between Assisi and Isernia is 371 km. The road distance is 286.2 km.
The best way to get from Assisi to Isernia without a car is to bus via Rome which takes 6h 20m and costs €30 - €50.
It takes approximately 6h 20m to get from Assisi to Isernia, including transfers.
Assisi to Isernia bus services, operated by Sulga Autolinee, depart from Assisi - Piazza San Pietro station.
Assisi to Isernia train services, operated by Trenitalia, depart from Assisi station.
The best way to get from Assisi to Isernia is to bus via Rome which takes 6h 20m and costs €30 - €50. Alternatively, you can train, which costs €40 - €70 and takes 6h 59m.
What companies run services between Assisi, Italy and Isernia, Italy?
You can take a bus from Assisi - Piazza San Pietro to Isernia via Roma, Autostazione Tiburtina in around 6h 20m. Alternatively, you can take a bus from P.za Matteotti Assisi to Isernia via Assisi, Assisi, and Roma Tiburtina in around 6h 59m.
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Assisi to Roma Tiburtina
- Ave. Duration
- 2h 32m
- Frequency
- 5 times a day
- Estimated price
- €19–27
- Website
- Trenitalia
Train from Roma Tiburtina to Isernia
- Ave. Duration
- 2h 14m
- Frequency
- 6 times a week
- Estimated price
- €22–30
- Website
- Trenitalia
Train from Foligno to Roma Termini
- Ave. Duration
- 2h 16m
- Frequency
- Every 2 hours
- Estimated price
- €17–25
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €22–35
- Website
- Trenitalia
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Assisi to Roma Tiburtina
- Ave. Duration
- 1h 42m
- Frequency
- Once daily
- Estimated price
- €17–35
- Website
- Trenitalia Intercity
Train from Foligno to Roma Termini
- Ave. Duration
- 2h 32m
- Frequency
- 3 times a day
- Estimated price
- €16–29
- Website
- Trenitalia Intercity
- Phone
- +39 06 5210550
- Website
- Trenitalia Frecce
Train from Foligno to Roma Termini
- Ave. Duration
- 1h 39m
- Frequency
- Once daily
- Estimated price
- €20–35
- Website
- Trenitalia Frecce
- Phone
- +39 075 5009641
- info@sulga.it
- Website
- sulga.it
Bus from Assisi - Piazza San Pietro to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 10m
- Frequency
- 6 times a week
- Estimated price
- €23–26
- Schedules at
- sulga.it
- 2nd Class
- €23–26
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- Flixbus
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 25m
- Frequency
- Twice daily
- Estimated price
- €15–23
- Website
- Flixbus
Bus from Assisi to Pescara
- Ave. Duration
- 3h 50m
- Frequency
- 3 times a day
- Estimated price
- €20–35
- Website
- Flixbus
Bus from Chieti to Isernia
- Ave. Duration
- 2h 9m
- Frequency
- 3 times a day
- Estimated price
- €11–18
- Website
- Flixbus
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Booking & Getting There
Assisi to Isernia bus services, operated by Sulga Autolinee, arrive at Roma, Autostazione Tiburtina station.
Assisi to Isernia train services, operated by Trenitalia, arrive at Roma Tiburtina station.
Yes, the driving distance between Assisi to Isernia is 286 km. It takes approximately 4h 13m to drive from Assisi to Isernia.
Book your Assisi to Isernia bus tickets online with Omio and 12go.asia.
There are 454+ hotels available in Isernia.