There are 9 ways to get from Palermo to Isernia by plane, train, car ferry, car, train (Trenitalia), bus, shuttle, or ferry
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Palermo Airport to Naples Airport, train
best- Fly from Palermo Airport (PMO) to Naples Airport (NAP)plane PMO - NAP
- Take the train from Caserta to Iserniatrain
6h 27m€38–141Ferry, bus
cheapest- Take the ferry from Port of Palermo to Naples Beverelloferry
- Take the bus from Napoli, Autostazione Metropark to Iserniabus 6
13h 46m€31–56Car ferry, drive
- Take the car ferry from Port of Palermo to Port of Naplescarferry
- Drive from Port of Naples to Iserniacar
11h 26m€43–81Train (Trenitalia)
- Take the train from Palermo Centrale to Napoli Centraletrain Ic
- Take the train from Napoli Centrale to Iserniatrain Re
12h 13m€80–175Bus
- Take the bus from Palermo to Caserta - Casagiovebus N592
- Take the bus from Caserta to Colli a Volturnobus
15h 39m€61–102Fly Palermo Airport to Fiumicino International Airport, train
- Fly from Palermo Airport (PMO) to Fiumicino International Airport (FCO)plane PMO - FCO
- Take the train from Roma Termini to Iserniatrain
6h 44m€61–184Shuttle to Trapani Airport, fly to Fiumicino International Airport, train
- Take a shuttle bus from Lazio Municipio to Trapani Birgi Airport
- Fly from Trapani Airport (TPS) to Fiumicino International Airport (FCO)plane TPS - FCO
- Take the train from Roma Termini to Iserniatrain
7h 44m€83–316Train to Catania–Fontanarossa Airport, fly to Naples Airport, train
- Take the train from Palermo Centrale to Catania Centraletrain
- Fly from Catania–Fontanarossa Airport (CTA) to Naples Airport (NAP)plane CTA - NAP
- Take the train from Caserta to Iserniatrain
9h 8m€67–188Shuttle to Trapani Airport, fly to Abruzzo Airport, bus
- Take a shuttle bus from Lazio Municipio to Trapani Birgi Airport
- Fly from Trapani Airport (TPS) to Abruzzo Airport (PSR)plane TPS - PSR
- Take the bus from Pescara to Iserniabus
8h 36m€70–281
Palermo to Isernia by train (Trenitalia)
Questions & Answers
The cheapest way to get from Palermo to Isernia is to ferry and bus which costs €30 - €60 and takes 13h 46m.
The fastest way to get from Palermo to Isernia is to fly and train which takes 6h 27m and costs €35 - €150.
No, there is no direct bus from Palermo to Isernia. However, there are services departing from Palermo and arriving at Isernia via Caserta and Colli a Volturno. The journey, including transfers, takes approximately 15h 39m.
No, there is no direct train from Palermo to Isernia. However, there are services departing from Palermo Centrale and arriving at Isernia via Napoli Centrale. The journey, including transfers, takes approximately 12h 13m.
The distance between Palermo and Isernia is 463 km.
The best way to get from Palermo to Isernia without a car is to train which takes 12h 13m and costs €80 - €180.
It takes approximately 6h 27m to get from Palermo to Isernia, including transfers.
Palermo to Isernia bus services, operated by FlixBus, depart from Palermo station.
Palermo to Isernia train services, operated by Trenitalia Intercity, depart from Palermo Centrale station.
The best way to get from Palermo to Isernia is to train which takes 12h 13m and costs €80 - €180. Alternatively, you can bus, which costs €60 - €110 and takes 15h 39m.
What companies run services between Palermo, Italy and Isernia, Italy?
You can take a train from Palermo Centrale to Isernia via Napoli Centrale in around 12h 13m. Alternatively, you can take a bus from Palermo to Isernia via Caserta, Colli a Volturno, and Colli a Volturno in around 15h 39m.
- Website
- ryanair.com
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Every day
- Estimated price
- €30–120
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 13m
- When
- Every day
- Estimated price
- €28–130
Flights from Trapani Airport to Fiumicino International Airport
- Ave. Duration
- 1h 15m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €40–180
Flights from Trapani Airport to Fiumicino International Airport via Malta
- Ave. Duration
- 3h 10m
- When
- Friday
- Estimated price
- €40–180
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €23–120
Flights from Catania–Fontanarossa Airport to Naples Airport via Malta
- Ave. Duration
- 3h 10m
- When
- Sunday
- Estimated price
- €23–120
Flights from Trapani Airport to Abruzzo Airport
- Ave. Duration
- 1h 10m
- When
- Wednesday to Sunday
- Estimated price
- €50–170
- Website
- easyjet.com
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 58 min
- When
- Every day
- Estimated price
- €21–100
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 8m
- When
- Every day
- Estimated price
- €21–110
- Website
- ita-airways.com
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 12m
- When
- Every day
- Estimated price
- €35–120
- Website
- aeroitalia.com
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €29–190
- Website
- flexflight.dk
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €29–190
- Website
- volotea.com
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €21–95
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Caserta to Isernia
- Ave. Duration
- 1h 18m
- Frequency
- 5 times a day
- Estimated price
- €11–20
- Website
- https://www.trenitalia.com/en.html
Train from Napoli Centrale to Isernia
- Ave. Duration
- 2h 3m
- Frequency
- 4 times a day
- Estimated price
- €15–27
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €23–40
- Website
- https://www.trenitalia.com/en.html
Train from Palermo Centrale to Catania Centrale
- Ave. Duration
- 2h 57m
- Frequency
- 5 times a day
- Estimated price
- €30–55
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Palermo Centrale to Napoli Centrale
- Ave. Duration
- 9h 10m
- Frequency
- Once daily
- Estimated price
- €65–150
- Website
- https://www.trenitalia.com/en.html
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Palermo to Caserta - Casagiove
- Ave. Duration
- 11h 55m
- Frequency
- Once daily
- Estimated price
- €50–90
- Website
- https://www.flixbus.co.uk
Bus from Pescara to Isernia
- Ave. Duration
- 2h 29m
- Frequency
- Once daily
- Estimated price
- €11–20
- Website
- https://www.flixbus.co.uk
- Phone
- +39 0871 344976
- satam@gruppolapanoramica.it
- Website
- satambus.it
Bus from Caserta to Colli a Volturno
- Ave. Duration
- 1h
- Frequency
- 3 times a week
- Estimated price
- €7–10
- Schedules at
- satambus.it
- customerservices@terravision.eu
- Website
- terravision.eu
Shuttle from Lazio Municipio to Trapani Birgi Airport
- Ave. Duration
- 1h 39m
- Frequency
- Every 4 hours
- Estimated price
- €11–50
- Website
- https://www.terravision.eu/
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Pescara to Isernia
- Ave. Duration
- 2h 15m
- Frequency
- Twice daily
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
- Phone
- 0865.221788
- info@satiautobus.com
- Website
- satiautobus.com
Bus from Napoli, Autostazione Metropark to Isernia
- Ave. Duration
- 1h 50m
- Frequency
- 3 times a day
- Estimated price
- €4–10
- Schedules at
- satiautobus.com
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Car ferry from Port of Palermo to Port of Naples
- Ave. Duration
- 10h
- Frequency
- 6 times a week
- Estimated price
- €35–60
- Website
- https://www.gnv.it/en
- Phone
- +39.081.496.444
- info@grimaldi.napoli.it
- Website
- grimaldi-lines.com
Car ferry from Port of Palermo to Port of Naples
- Ave. Duration
- 8h 30m
- Frequency
- 4 times a week
- Estimated price
- €25–45
- Website
- https://www.grimaldi-lines.com/en/
Ferry from Port of Palermo to Naples Beverello
- Ave. Duration
- 10h 30m
- Frequency
- Once daily
- Estimated price
- €25–45
- Website
- https://www.grimaldi-lines.com/en/
Want to know more about travelling around Italy
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
Want to know more about Flixbus?
Read the travel guide
Getting to Rome from the airport
Read the travel guide
More Questions & Answers
Palermo to Isernia bus services, operated by FlixBus, arrive at Caserta - Casagiove station.
Palermo to Isernia train services, operated by Trenitalia Intercity, arrive at Napoli Centrale station.
Book your Palermo to Isernia train tickets online with Omio.
There are 422+ hotels available in Isernia.
































