There are 7 ways to get from Palermo to Isernia by plane, train, ferry, car, bus, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Palermo Airport to Naples Airport, train
best- Fly from Palermo Airport (PMO) to Naples Airport (NAP)plane PMO - NAP
- Take the train from Napoli Centrale to Iserniatrain
6h 4m€34–133Ferry, drive
- Take the ferry from Port of Palermo to Naples Beverelloferry
- Drive from Naples Beverello to Iserniacar
11h 58m€51–72Bus
- Take the bus from Palermo Via Tommaso Fazello to Caserta Viale Vittorio Venetobus Autoservizi Salemi S202
- Take the bus from Caserta Terminal Bus to Iserniabus 433
12h 4m€35–51Train (Trenitalia)
- Take the train from Palermo Centrale to Napoli Centraletrain Ic
- Take the train from Napoli Centrale to Iserniatrain Re
12h 13m€73–159Fly Palermo Airport to Fiumicino International Airport, train
- Fly from Palermo Airport (PMO) to Fiumicino International Airport (FCO)plane PMO - FCO
- Take the train from Roma Termini to Iserniatrain
6h 44m€48–178Train to Catania–Fontanarossa Airport, fly to Naples Airport, train
- Take the train from Palermo Centrale to Catania Centraletrain
- Fly from Catania–Fontanarossa Airport (CTA) to Naples Airport (NAP)plane CTA - NAP
- Take the train from Napoli Centrale to Iserniatrain
8h 39m€47–163Ferry, bus
- Take the ferry from Port of Palermo to Naples Beverelloferry
- Take the bus from Napoli P.zza Garibaldi to Iserniabus 433
14h 2m€42–61
Palermo to Isernia by bus
Questions & Answers
The cheapest way to get from Palermo to Isernia is to bus which costs €35 - €55 and takes 12h 4m.
The fastest way to get from Palermo to Isernia is to fly and train which takes 6h 4m and costs €30 - €140.
No, there is no direct bus from Palermo to Isernia. However, there are services departing from Palermo Via Tommaso Fazello and arriving at Isernia via Caserta Terminal Bus. The journey, including transfers, takes approximately 12h 4m.
No, there is no direct train from Palermo to Isernia. However, there are services departing from Palermo Centrale and arriving at Isernia via Napoli Centrale. The journey, including transfers, takes approximately 12h 13m.
The distance between Palermo and Isernia is 477 km.
The best way to get from Palermo to Isernia without a car is to bus which takes 12h 4m and costs €35 - €55.
It takes approximately 6h 4m to get from Palermo to Isernia, including transfers.
Palermo to Isernia bus services, operated by Autoservizi Salemi Srl, depart from Palermo Via Tommaso Fazello station.
Palermo to Isernia train services, operated by Trenitalia Intercity, depart from Palermo Centrale station.
The best way to get from Palermo to Isernia is to bus which takes 12h 4m and costs €35 - €55. Alternatively, you can train, which costs €70 - €160 and takes 12h 13m.
What companies run services between Palermo, Italy and Isernia, Italy?
You can take a bus from Palermo Via Tommaso Fazello to Isernia via Caserta Viale Vittorio Veneto and Caserta Terminal Bus in around 12h 4m. Alternatively, you can take a train from Palermo Centrale to Isernia via Napoli Centrale in around 12h 13m.
- Website
- ryanair.com
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €40–110
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €28–150
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 10m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €26–130
- Website
- easyjet.com
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 55 min
- When
- Every day
- Estimated price
- €21–100
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- €21–110
- Website
- ita-airways.com
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 11m
- When
- Every day
- Estimated price
- €35–130
- Website
- aeroitalia.com
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €30–190
- Website
- flexflight.dk
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €30–190
- Website
- volotea.com
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- €20–95
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Napoli Centrale to Isernia
- Ave. Duration
- 2h 3m
- Frequency
- 4 times a day
- Estimated price
- €8–13
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
Train from Palermo Centrale to Catania Centrale
- Ave. Duration
- 2h 57m
- Frequency
- 5 times a day
- Estimated price
- €14–21
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Palermo Centrale to Napoli Centrale
- Ave. Duration
- 9h 10m
- Frequency
- Once daily
- Estimated price
- €60–150
- Website
- https://www.trenitalia.com/en.html
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Palermo Via Tommaso Fazello to Caserta Viale Vittorio Veneto
- Ave. Duration
- 9h 50m
- Frequency
- Once daily
- Estimated price
- €30–45
- Schedules at
- autoservizisalemi.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Caserta Terminal Bus to Isernia
- Ave. Duration
- 1h 14m
- Frequency
- Once daily
- Estimated price
- €5–9
- Website
- https://www.flixbus.co.uk
Bus from Napoli P.zza Garibaldi to Isernia
- Ave. Duration
- 2h 9m
- Frequency
- Once daily
- Estimated price
- €6–12
- Website
- https://www.flixbus.co.uk
- Phone
- +39.081.496.444
- info@grimaldi.napoli.it
- Website
- grimaldi-lines.com
Ferry from Port of Palermo to Naples Beverello
- Ave. Duration
- 10h 30m
- Frequency
- Once daily
- Estimated price
- €35–50
- Website
- https://www.grimaldi-lines.com/en/
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More Questions & Answers
Palermo to Isernia bus services, operated by Autoservizi Salemi Srl, arrive at Caserta Viale Vittorio Veneto station.
Palermo to Isernia train services, operated by Trenitalia Intercity, arrive at Napoli Centrale station.
Book your Palermo to Isernia train tickets online with Omio.
Book your Palermo to Isernia bus tickets online with Omio.
There are 435+ hotels available in Isernia.















