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How to get fromMurphysboro to Milwaukeeby bus, train (Amtrak), car, plane, bus (Flixbus, Greyhound), train or taxi

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There are 8 ways to get from Murphysboro to Milwaukee by bus, train (Amtrak), car, plane, bus (Flixbus, Greyhound), train, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Marathon Gas Station - Marion to Water & Chicago - Circle Kbus bus Milwaukee
    8h 4m
    $131–251

  2. Drive 419.7 mi

    cheapest
    1. Drive from Murphysboro to Milwaukeecar car 419.7 mi
    7h 14m
    $77–111

  3. Train (Amtrak)

    1. Take the train from Carbondale to Chicago Union Stationtrain train Saluki / ...
    2. Take the train from Chicago Union Station to Milwaukeetrain train Hiawatha Service / ...
    8h 10m
    $81–183

  4. Bus to Lambert–St. Louis International Airport, fly to General Mitchell International Airport

    1. Take the bus from Carbondale to St. Louisbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to General Mitchell International Airport (MKE)plane plane STL - MKE
    5h 47m
    $197–1,019

  5. Bus via Chicago

    1. Take the bus from Carbondale Intermodal Station to Chicago Bus Stationbus bus FlixBus N2521
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus Greyhound US0150 / ...
    12h 25m
    $93–208

  6. Fly Williamson County Regional Airport to Chicago O'Hare International Airport, train

    1. Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane plane MWA - ORD
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    5h 26m
    $133–273

  7. Fly Williamson County Regional Airport to General Mitchell International Airport

    1. Fly from Williamson County Regional Airport (MWA) to General Mitchell International Airport (MKE)plane plane MWA - MKE
    4h 47m
    $212–811

  8. Taxi to Cape Girardeau Municipal Airport, fly to Chicago O'Hare International Airport, train

    1. Take the taxi from Murphysboro to Cape Girardeau Municipal Airport (CGI)taxi taxi
    2. Fly from Cape Girardeau Municipal Airport (CGI) to Chicago O'Hare International Airport (ORD)plane plane CGI - ORD
    3. Take the train from Chicago Union Station to Milwaukeetrain train
    6h 19m
    $206–353

Lambert–St. Louis International Airport (STL) to General Mitchell International Airport (MKE) flights

Calendar16Weekly Planes
Duration1h 58mAverage Duration
Ticket$149Cheapest Price
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Questions & Answers

What companies run services between Murphysboro, IL, USA and Milwaukee, WI, USA?

Tornado Bus Company operates a bus from Marathon Gas Station - Marion to Water & Chicago - Circle K once daily. Tickets cost $80–190 and the journey takes 7h 35m. Alternatively, you can take a vehicle from Murphysboro to Milwaukee via Carbondale and Chicago Union Station in around 8h 10m.

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