There are 7 ways to get from Murphysboro to Milwaukee by plane, bus, train (Amtrak), car, or bus (Amtrak, Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Williamson County Regional Airport to General Mitchell International Airport
best- Fly from Williamson County Regional Airport (MWA) to General Mitchell International Airport (MKE)plane MWA - MKE
4h 37m$137–611Drive 419.7 mi
cheapest- Drive from Murphysboro to Milwaukeecar 419.7 mi
7h 18m$77–111Bus
- Take the bus from Marathon Gas Station - Marion to Water & Chicago - Circle Kbus Milwaukee
8h 4m$131–251Train (Amtrak)
- Take the train from Carbondale to Chicago Union Stationtrain Saluki / ...
- Take the train from Chicago Union Station to Milwaukeetrain Hiawatha Service / ...
8h 10m$146–288Fly Williamson County Regional Airport to Chicago O'Hare International Airport, bus
- Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane MWA - ORD
- Take the bus from Chicago to Milwaukee Intermodal Stationbus
4h 37m$148–306Bus to Lambert–St. Louis International Airport, fly to General Mitchell International Airport
- Take the bus from Carbondale to St. Louisbus
- Fly from Lambert–St. Louis International Airport (STL) to General Mitchell International Airport (MKE)plane STL - MKE
5h 41m$519–929Bus via Chicago
- Take the bus from Carbondale to St. Louisbus
- Take the bus from St Louis Bus Station to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus
11h 56m$91–179
Williamson County Regional Airport (MWA) to General Mitchell International Airport (MKE) flights
Questions & Answers
The cheapest way to get from Murphysboro to Milwaukee is to drive which costs $75 - $120 and takes 7h 18m.
The fastest way to get from Murphysboro to Milwaukee is to fly and bus which takes 4h 37m and costs $140 - $310.
No, there is no direct bus from Murphysboro station to Milwaukee. However, there are services departing from Marathon Gas Station - Marion and arriving at Water & Chicago - Circle K via . The journey, including transfers, takes approximately 8h 4m.
No, there is no direct train from Murphysboro to Milwaukee. However, there are services departing from Carbondale and arriving at Milwaukee via Chicago Union Station. The journey, including transfers, takes approximately 8h 10m.
The distance between Murphysboro and Milwaukee is 393 miles. The road distance is 422.1 miles.
The best way to get from Murphysboro to Milwaukee without a car is to bus which takes 8h 4m and costs $130 - $260.
It takes approximately 4h 37m to get from Murphysboro to Milwaukee, including transfers.
Murphysboro to Milwaukee bus services, operated by Amtrak, depart from Carbondale station.
Murphysboro to Milwaukee train services, operated by Amtrak, depart from Carbondale station.
The best way to get from Murphysboro to Milwaukee is to fly which takes 4h 37m and costs $130 - $650. Alternatively, you can bus, which costs $130 - $260 and takes 8h 4m, you could also train, which costs $140 - $290 and takes 8h 10m.
What companies run services between Murphysboro, IL, USA and Milwaukee, WI, USA?
American Airlines and Corporate Flight Management Inc fly from Williamson County Regional Airport (MWA) to General Mitchell International Airport (MKE) once daily. Alternatively, Tornado Bus Company operates a bus from Marathon Gas Station - Marion to Water & Chicago - Circle K once daily. Tickets cost $80–190 and the journey takes 7h 35m.
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to General Mitchell International Airport
- Ave. Duration
- 1h 11m
- When
- Every day
- Estimated price
- $90–600
Flights from Lambert–St. Louis International Airport to General Mitchell International Airport via Chicago Midway
- Ave. Duration
- 3h 10m
- When
- Monday, Thursday, and Friday
- Estimated price
- $95–600
- Website
- aa.com
Flights from Williamson County Regional Airport to General Mitchell International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 3h 46m
- When
- Sunday, Monday, Wednesday, Thursday, Friday, and Tuesday
- Estimated price
- $85–750
Flights from Williamson County Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 44m
- When
- Every day
- Estimated price
- $40–280
- Website
- contouraviation.com
Flights from Williamson County Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $85–220
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Carbondale to Chicago Union Station
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- $100–210
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Milwaukee
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $27–55
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 888 358 6762
- info@tornadobus.com
- Website
- tornadobus.com
Bus from Marathon Gas Station - Marion to Water & Chicago - Circle K
- Ave. Duration
- 7h 35m
- Frequency
- Once daily
- Estimated price
- $80–190
- Schedules at
- tornadobus.com
- Adults 11-59
- $80–190
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Chicago to Milwaukee Intermodal Station
- Ave. Duration
- 1h 20m
- Frequency
- Once daily
- Estimated price
- $12–23
- Website
- https://www.greyhound.com/
Bus from Chicago Bus Station to Milwaukee Intermodal Station
- Ave. Duration
- 1h 40m
- Frequency
- 4 times a day
- Estimated price
- $13–26
- Website
- https://www.greyhound.com/
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Carbondale to St. Louis
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $30–50
- Website
- https://www.amtrak.com/home.html
Bus from Carbondale to St. Louis
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $30–50
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Carbondale to St. Louis
- Ave. Duration
- 1h 55m
- Frequency
- 5 times a week
- Estimated price
- $14–25
- Schedules at
- flixbus.com
Bus from Carbondale to St. Louis
- Ave. Duration
- 1h 55m
- Frequency
- 5 times a week
- Estimated price
- $14–25
- Schedules at
- flixbus.com
Bus from St Louis Bus Station to Chicago Bus Station
- Ave. Duration
- 6h 5m
- Frequency
- Twice daily
- Estimated price
- $45–80
- Schedules at
- flixbus.com
Bus from Chicago Bus Station to Milwaukee Intermodal Station
- Ave. Duration
- 1h 55m
- Frequency
- 3 times a day
- Estimated price
- $13–23
- Schedules at
- flixbus.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
Murphysboro to Milwaukee bus services, operated by Amtrak, arrive at St. Louis station.
Murphysboro to Milwaukee train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Murphysboro to Milwaukee is 422 miles. It takes approximately 7h 18m to drive from Murphysboro to Milwaukee.
Book your Murphysboro to Milwaukee train tickets online with Omio.
Book your Murphysboro to Milwaukee bus tickets online with Omio.
There are 245+ hotels available in Milwaukee.