There are 6 ways to get from Murphysboro to Chicago by plane, train (Amtrak), bus (Amtrak, Flixbus), car, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Williamson County Regional Airport
best- Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane MWA - ORD
2h 52m$136–273Drive to Barkley Regional Airport, fly
cheapest- Drive from Murphysboro to Barkley Regional Airport (PAH)car
- Fly from Barkley Regional Airport (PAH) to Chicago O'Hare International Airport (ORD)plane PAH - ORD
3h 41m$51–265Train (Amtrak)
- Take the train from Carbondale to Chicago Union Stationtrain Saluki / ...
5h 41m$119–223Bus
- Take the bus from Carbondale to St. Louisbus Amtrak Thruway Connecting Service
- Take the bus from St Louis Bus Station to Chicago Bus Stationbus FlixBus 2510 / ...
9h 16m$77–148Drive 331.9 mi
- Drive from Murphysboro to Chicagocar 331.9 mi
5h 44m$61–88Taxi to Cape Girardeau Municipal Airport, fly
- Take the taxi from Murphysboro to Cape Girardeau Municipal Airport (CGI)taxi
- Fly from Cape Girardeau Municipal Airport (CGI) to Chicago O'Hare International Airport (ORD)plane CGI - ORD
3h 45m$184–363
Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD) flights
Questions & Answers
The cheapest way to get from Murphysboro to Chicago is to drive which costs $60 - $90 and takes 5h 44m.
The fastest way to get from Murphysboro to Chicago is to fly which takes 2h 52m and costs $130 - $280.
No, there is no direct bus from Murphysboro to Chicago station. However, there are services departing from Carbondale and arriving at Chicago Bus Station via St Louis Bus Station. The journey, including transfers, takes approximately 9h 16m.
No, there is no direct train from Murphysboro to Chicago station. However, there are services departing from Carbondale and arriving at Chicago Union Station via . The journey, including transfers, takes approximately 5h 41m.
The distance between Murphysboro and Chicago is 337 miles. The road distance is 333.9 miles.
The best way to get from Murphysboro to Chicago without a car is to train which takes 5h 41m and costs $110 - $230.
It takes approximately 2h 52m to get from Murphysboro to Chicago, including transfers.
Murphysboro to Chicago bus services, operated by Amtrak, depart from Carbondale station.
Murphysboro to Chicago train services, operated by Amtrak, depart from Carbondale station.
The best way to get from Murphysboro to Chicago is to fly which takes 2h 52m and costs $130 - $280. Alternatively, you can train, which costs $110 - $230 and takes 5h 41m, you could also bus, which costs $75 - $150 and takes 9h 16m.
What companies run services between Murphysboro, IL, USA and Chicago, IL, USA?
Corporate Flight Management Inc and American Airlines fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD) 3 times a day. Alternatively, Amtrak operates a train from Carbondale to Chicago Union Station 3 times a day. Tickets cost $100–200 and the journey takes 5h 30m.
- Website
- contouraviation.com
Flights from Williamson County Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $85–210
Flights from Cape Girardeau Municipal Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 45m
- When
- Every day
- Estimated price
- $65–220
- Website
- aa.com
Flights from Williamson County Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 44m
- When
- Every day
- Estimated price
- $40–260
- Website
- united.com
Flights from Barkley Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 28m
- When
- Every day
- Estimated price
- $35–240
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Carbondale to Chicago Union Station
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- $100–200
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Carbondale to St. Louis
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $30–50
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Carbondale to St. Louis
- Ave. Duration
- 1h 55m
- Frequency
- 5 times a week
- Estimated price
- $13–23
- Schedules at
- flixbus.com
Bus from St Louis Bus Station to Chicago Bus Station
- Ave. Duration
- 6h 5m
- Frequency
- Twice daily
- Estimated price
- $45–75
- Schedules at
- flixbus.com
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More Questions & Answers
Murphysboro to Chicago bus services, operated by Amtrak, arrive at St. Louis station.
Murphysboro to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Murphysboro to Chicago is 334 miles. It takes approximately 5h 44m to drive from Murphysboro to Chicago.
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Book your Murphysboro to Chicago bus tickets online with Omio.
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