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How to get fromMurphysboro to Chicagoby plane, train (Amtrak), bus (Flixbus), car or taxi

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There are 6 ways to get from Murphysboro to Chicago by plane, train (Amtrak), bus (Flixbus), car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Williamson County Regional Airport

    best
    1. Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane plane MWA - ORD
    2h 49m
    $111–233

  2. Train (Amtrak)

    cheapest
    1. Take the train from Carbondale to Chicago Union Stationtrain train Saluki / ...
    5h 41m
    $54–108

  3. Bus (Flixbus)

    1. Take the bus from Carbondale Intermodal Station to Chicago Bus Stationbus bus FlixBus N2521
    9h 41m
    $69–123

  4. Drive 331.9 mi

    1. Drive from Murphysboro to Chicagocar car 331.9 mi
    5h 44m
    $61–88

  5. Taxi to Cape Girardeau Municipal Airport, fly

    1. Take the taxi from Murphysboro to Cape Girardeau Municipal Airport (CGI)taxi taxi
    2. Fly from Cape Girardeau Municipal Airport (CGI) to Chicago O'Hare International Airport (ORD)plane plane CGI - ORD
    3h 41m
    $179–313

  6. Drive to Barkley Regional Airport, fly

    1. Drive from Murphysboro to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Chicago O'Hare International Airport (ORD)plane plane PAH - ORD
    3h 59m
    $206–1,625

Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD) flights

Calendar12Weekly Planes
Duration1h 35mAverage Duration
Ticket$60Cheapest Price
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Questions & Answers

What companies run services between Murphysboro, IL, USA and Chicago, IL, USA?

Corporate Flight Management Inc flies from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD) twice daily. Alternatively, Amtrak operates a train from Carbondale to Chicago Union Station 3 times a day. Tickets cost $35–85 and the journey takes 5h 30m.

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