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How to get fromMurphysboro to Chicagoby plane, train (Amtrak), bus (Amtrak, Flixbus), car, or taxi

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There are 6 ways to get from Murphysboro to Chicago by plane, train (Amtrak), bus (Amtrak, Flixbus), car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Williamson County Regional Airport

    best
    1. Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane plane MWA - ORD
    2h 52m
    $146–273

  2. Drive to Barkley Regional Airport, fly

    cheapest
    1. Drive from Murphysboro to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Chicago O'Hare International Airport (ORD)plane plane PAH - ORD
    3h 41m
    $51–265

  3. Train (Amtrak)

    1. Take the train from Carbondale to Chicago Union Stationtrain train Saluki / ...
    5h 41m
    $109–223

  4. Bus

    1. Take the bus from Carbondale to St. Louisbus bus Amtrak Thruway Connecting Service
    2. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus FlixBus 2510 / ...
    9h 16m
    $71–143

  5. Drive 331.9 mi

    1. Drive from Murphysboro to Chicagocar car 331.9 mi
    5h 44m
    $61–88

  6. Taxi to Cape Girardeau Municipal Airport, fly

    1. Take the taxi from Murphysboro to Cape Girardeau Municipal Airport (CGI)taxi taxi
    2. Fly from Cape Girardeau Municipal Airport (CGI) to Chicago O'Hare International Airport (ORD)plane plane CGI - ORD
    3h 45m
    $184–353

Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD) flights

Calendar19Weekly Planes
Duration1h 41mAverage Duration
Ticket$40Cheapest Price
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Questions & Answers

Map of how to get from Murphysboro to Chicago.ExpandLaunch map view
  • Distance: 335.3 mi
  • Duration: 2h 52m

What companies run services between Murphysboro, IL, USA and Chicago, IL, USA?

Corporate Flight Management Inc and American Airlines fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD) 3 times a day. Alternatively, Amtrak operates a train from Carbondale to Chicago Union Station 3 times a day. Tickets cost $90–200 and the journey takes 5h 30m.

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