There are 5 ways to get from Murphysboro to Cincinnati by bus (Flixbus, Greyhound), car, plane, train, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Carbondale Intermodal Station to Clarksville Park & Ridebus
- Take the bus from Clarksville Park & Ride to Louisville Bus Stationbus
- Take the bus from Louisville to Cincinnatibus
10h 21m$79–158Drive 322.8 mi
cheapest- Drive from Murphysboro to Cincinnaticar 322.8 mi
5h 57m$59–86Fly from Williamson County Regional Airport
- Fly from Williamson County Regional Airport (MWA) to Covington (CVG)plane MWA - CVG
8h 35m$171–810Train, bus
- Take the train from Carbondale to Champaign-Urbanatrain
- Take the bus from Champaign Intermodal Trans Ctr to Indianapolis Union Stationbus
- Take the bus from Indianapolis Union Station to Dayton Trotwood Bus Stationbus
- Take the bus from Dayton Trotwood Bus Station to Cincinnatibus
11h 6m$106–209Bus to Lambert–St. Louis International Airport, fly
- Take the bus from Carbondale to St. Louisbus
- Fly from Lambert–St. Louis International Airport (STL) to Covington (CVG)plane STL - CVG
7h 59m$638–1,018
Williamson County Regional Airport (MWA) to Covington (CVG) flights
Questions & Answers
The cheapest way to get from Murphysboro to Cincinnati is to drive which costs $55 - $85 and takes 5h 57m.
The fastest way to get from Murphysboro to Cincinnati is to drive which takes 5h 57m and costs $55 - $85.
No, there is no direct bus from Murphysboro station to Cincinnati. However, there are services departing from Carbondale Intermodal Station and arriving at Cincinnati via Clarksville Park & Ride and Louisville. The journey, including transfers, takes approximately 10h 21m.
The distance between Murphysboro and Cincinnati is 453 miles. The road distance is 324.6 miles.
The best way to get from Murphysboro to Cincinnati without a car is to bus which takes 10h 21m and costs $75 - $160.
It takes approximately 10h 21m to get from Murphysboro to Cincinnati, including transfers.
Murphysboro to Cincinnati bus services, operated by Flixbus USA, depart from Carbondale Intermodal Station.
The best way to get from Murphysboro to Cincinnati is to bus which takes 10h 21m and costs $75 - $160. Alternatively, you can fly, which costs $170 - $850 and takes 8h 35m.
Murphysboro to Cincinnati bus services, operated by Flixbus USA, arrive at Clarksville Park & Ride station.
Cincinnati is 1h ahead of Murphysboro. It is currently 12:09 PM in Murphysboro and 1:09 PM in Cincinnati.
What companies run services between Murphysboro, IL, USA and Cincinnati, OH, USA?
You can take a vehicle from Murphysboro to Cincinnati via Carbondale Intermodal Station, Clarksville Park & Ride, and Louisville in around 10h 21m. Alternatively, American Airlines flies from Williamson County Regional Airport (MWA) to Covington (CVG) twice daily.
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Covington via Chicago Midway
- Ave. Duration
- 3h 33m
- When
- Tuesday, Wednesday, Monday, Thursday, Friday, and Sunday
- Estimated price
- $110–700
Flights from Lambert–St. Louis International Airport to Covington via Nashville
- Ave. Duration
- 3h 41m
- When
- Saturday, Monday, Thursday, Friday, and Sunday
- Estimated price
- $110–700
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Carbondale to Champaign-Urbana
- Ave. Duration
- 2h 50m
- Frequency
- 3 times a day
- Estimated price
- $45–110
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Carbondale Intermodal Station to Clarksville Park & Ride
- Ave. Duration
- 3h 5m
- Frequency
- 5 times a week
- Estimated price
- $24–40
- Schedules at
- Flixbus USA
Bus from Dayton Trotwood Bus Station to Cincinnati
- Ave. Duration
- 55 min
- Frequency
- 4 times a week
- Estimated price
- $8–13
- Schedules at
- Flixbus USA
Bus from Carbondale to St. Louis
- Ave. Duration
- 1h 55m
- Frequency
- 5 times a week
- Estimated price
- $14–23
- Schedules at
- Flixbus USA
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More Questions & Answers
Yes, the driving distance between Murphysboro to Cincinnati is 325 miles. It takes approximately 5h 57m to drive from Murphysboro to Cincinnati.
There are 662+ hotels available in Cincinnati.




