There are 7 ways to get from Murphysboro to Cincinnati by bus (Amtrak, Flixbus, Greyhound), train, bus, car, plane, or bus (Flixbus, Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Carbondale to St. Louisbus
- Take the bus from St Louis Bus Station to Indianapolis Union Stationbus
- Take the bus from Indianapolis to Cincinnatibus
10h 50m$91–213Drive 322.8 mi
cheapest- Drive from Murphysboro to Cincinnaticar 322.8 mi
5h 57m$59–86Train, bus
- Take the train from Carbondale to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Indianapolistrain
- Take the bus from Indianapolis to Cincinnatibus
14h 49m$99–293Drive to Barkley Regional Airport, fly
- Drive from Murphysboro to Barkley Regional Airport (PAH)car
- Fly from Barkley Regional Airport (PAH) to Covington (CVG)plane PAH - CVG
8h 19m$246–1,322Bus via Nashville
- Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus
- Take the bus from Nashville to Louisville, KYbus
- Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus
11h 28m$83–208Fly from Williamson County Regional Airport
- Fly from Williamson County Regional Airport (MWA) to Covington (CVG)plane MWA - CVG
5h 18m$221–910Bus to Nashville, fly
- Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus
- Fly from Nashville (BNA) to Covington (CVG)plane BNA - CVG
7h 59m$128–667
Barkley Regional Airport (PAH) to Covington (CVG) flights
Questions & Answers
The cheapest way to get from Murphysboro to Cincinnati is to drive which costs $55 - $85 and takes 5h 57m.
The fastest way to get from Murphysboro to Cincinnati is to fly which takes 5h 18m and costs $220 - $950.
The distance between Murphysboro and Cincinnati is 459 miles. The road distance is 324.6 miles.
The best way to get from Murphysboro to Cincinnati without a car is to bus which takes 10h 50m and costs $90 - $220.
It takes approximately 10h 50m to get from Murphysboro to Cincinnati, including transfers.
The best way to get from Murphysboro to Cincinnati is to bus which takes 10h 50m and costs $90 - $220. Alternatively, you can fly, which costs $220 - $950 and takes 5h 18m.
Cincinnati is 1h ahead of Murphysboro. It is currently 11:11 PM in Murphysboro and 12:11 AM in Cincinnati.
Yes, the driving distance between Murphysboro to Cincinnati is 325 miles. It takes approximately 5h 57m to drive from Murphysboro to Cincinnati.
There are 728+ hotels available in Cincinnati.
What companies run services between Murphysboro, IL, USA and Cincinnati, OH, USA?
You can take a vehicle from Murphysboro to Cincinnati via Carbondale, St. Louis, St Louis Bus Station, Indianapolis, Illinois St (Greyhound Bus Station), and Indianapolis in around 10h 50m. Alternatively, Corporate Flight Management Inc, United Airlines, and two other airlines fly from Williamson County Regional Airport (MWA) to Covington (CVG) 4 times a day.
- Website
- united.com
Flights from Barkley Regional Airport to Covington via Chicago O'Hare
- Ave. Duration
- 7h 21m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $230–1,300
Flights from Barkley Regional Airport to Covington via Houston
- Ave. Duration
- 8h 39m
- When
- Tuesday to Saturday
- Estimated price
- $420–1,900
Flights from Williamson County Regional Airport to Covington via Chicago O'Hare
- Ave. Duration
- 4h 16m
- When
- Every day
- Estimated price
- $190–900
Flights from Williamson County Regional Airport to Covington via Chicago O'Hare, Toronto
- Ave. Duration
- 8h 35m
- When
- Every day
- Estimated price
- $170–850
- Website
- aircanada.com
Flights from Williamson County Regional Airport to Covington via Chicago O'Hare
- Ave. Duration
- 4h 16m
- When
- Every day
- Estimated price
- $190–900
Flights from Williamson County Regional Airport to Covington via Chicago O'Hare, Toronto
- Ave. Duration
- 8h 35m
- When
- Every day
- Estimated price
- $170–850
- Website
- aa.com
Flights from Barkley Regional Airport to Covington via Charlotte
- Ave. Duration
- 7h 2m
- When
- Every day
- Estimated price
- $500–2,300
- Website
- southwest.com
Flights from Nashville to Covington
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- $80–550
- Website
- delta.com
Flights from Williamson County Regional Airport to Covington via Chicago O'Hare, Detroit
- Ave. Duration
- 7h 59m
- When
- Every day
- Estimated price
- $250–1,200
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Carbondale to Chicago Union Station
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- $35–120
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Indianapolis
- Ave. Duration
- 4h 54m
- Frequency
- 3 times a week
- Estimated price
- $30–65
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Carbondale to St. Louis
- Ave. Duration
- 2h
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Carbondale to St. Louis
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- $22–40
- Schedules at
- flixbus.com
Bus from Indianapolis to Cincinnati
- Ave. Duration
- 2h
- Frequency
- 6 times a week
- Estimated price
- $15–85
- Schedules at
- flixbus.com
- Adult
- $15–85
Bus from Carbondale Intermodal Station to Nashville Bus Station
- Ave. Duration
- 3h 45m
- Frequency
- Once daily
- Estimated price
- $25–90
- Schedules at
- flixbus.com
- Adult
- $25–90
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from St Louis Bus Station to Indianapolis Union Station
- Ave. Duration
- 4h 25m
- Frequency
- 3 times a day
- Estimated price
- $35–65
- Website
- https://www.greyhound.com/
Rome2Rio's guide to Amtrak Thruway
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Nashville to Louisville, KY
- Ave. Duration
- 3h 40m
- Frequency
- Twice daily
- Estimated price
- $30–50
- Website
- https://www.amtrak.com/home.html
- Adult
- $30–50
- Phone
- +1 888-378-3823
- info@baronsbus.com
- Website
- baronsbus.com
Bus from Louisville, KY Bus Station to Cincinnati - Downtown
- Ave. Duration
- 1h 52m
- Frequency
- Once daily
- Estimated price
- $9–45
- Website
- https://baronsbus.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide














