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How to get fromManhattan to Depewby bus, plane, train, bus (Flixbus), car or bus (Greyhound)

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There are 7 ways to get from Manhattan to Depew by bus, plane, train, bus (Flixbus), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Laguardia Airport, fly

    best
    1. Take the bus from E 125 St/Lexington Av to Laguardia Rd/94 Stbus
    2. Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)planeLGA - BUF
    3h 4m
    $160–928

  2. Bus via Port Authority Bus Terminal

    cheapest
    1. Take the bus from Port Authority Bus Terminal to BuffalobusGreyhound US0215 / ...
    10h 39m
    $55–114

  3. Train

    1. Take the train from New York Penn Station to BuffalotrainVIA Rail
    9h 13m
    $64–119

  4. Bus (Flixbus)

    1. Take the bus from New York Midtown to BuffalobusFlixBus N2686 / ...
    10h 15m
    $56–110

  5. Drive 351.5 mi

    1. Drive from Manhattan to Depewcar351.5 mi
    7h 8m
    $65–93

  6. Fly from Newark Liberty International Airport

    1. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)planeEWR - BUF
    3h 14m
    $157–848

  7. Fly from John F. Kennedy International Airport

    1. Fly from John F. Kennedy International Airport (JFK) to Buffalo Niagara International Airport (BUF)planeJFK - BUF
    3h 17m
    $161–889

Manhattan to Depew by train and bus

Calendar5Weekly Services
Duration9h 13mAverage Duration
Ticket$64Cheapest Price
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Questions & Answers

What companies run services between Manhattan, NY, USA and Depew, NY, USA?

VIA Rail operates a train from New York Penn Station to Buffalo once daily. Tickets cost $60–120 and the journey takes 8h 10m. Alternatively, Flixbus USA operates a bus from New York Midtown to Buffalo every 4 hours. Tickets cost $50–110 and the journey takes 8h 16m.

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