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How to get fromPoughkeepsie to Depewby train (Amtrak), car, train, or plane

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There are 7 ways to get from Poughkeepsie to Depew by train (Amtrak), car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Poughkeepsie Amtrak Station to Buffalo Depew Stationtrain train Maple Leaf / ...
    6h 38m
    $105–264

  2. Drive 322 mi

    cheapest
    1. Drive from Poughkeepsie to Depewcar car 322 mi
    6h 27m
    $59–85

  3. Train to Laguardia Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)plane plane LGA - BUF
    4h 52m
    $127–656

  4. Train to John F. Kennedy International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Poughkeepsie to Grand Central Terminaltrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Buffalo Niagara International Airport (BUF)plane plane JFK - BUF
    5h 1m
    $125–538

  5. Train to Newark Liberty International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane plane EWR - BUF
    4h 48m
    $131–576

  6. Train to Laguardia Airport, fly to Rochester, train

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Rochester (ROC)plane plane LGA - ROC
    3. Take the train from Rochester to Buffalo Depew Stationtrain train
    6h 55m
    $143–778

  7. Train to Newark Liberty International Airport, fly to Rochester, train

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Rochester (ROC)plane plane EWR - ROC
    3. Take the train from Rochester to Buffalo Depew Stationtrain train
    6h 45m
    $507–1,568

Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF) flights

Calendar64Weekly Planes
Duration2h 9mAverage Duration
Ticket$92Cheapest Price
See schedules

Questions & Answers

Map of how to get from Poughkeepsie to Depew.ExpandLaunch map view
  • Distance: 359.7 mi
  • Duration: 6h 38m

What companies run services between Poughkeepsie, NY, USA and Depew, NY, USA?

Amtrak operates a train from Poughkeepsie Amtrak Station to Buffalo Depew Station 4 times a day. Tickets cost $110–230 and the journey takes 6h 34m. VIA Rail also services this route once daily.

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