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How to get fromPoughkeepsie to Depewby train (Amtrak), car, train, plane or bus

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There are 6 ways to get from Poughkeepsie to Depew by train (Amtrak), car, train, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Poughkeepsie Amtrak Station to Buffalo Depew StationtrainMaple Leaf / ...
    7h 37m
    $54–129

  2. Drive 322 mi

    1. Drive from Poughkeepsie to Depewcar322 mi
    6h 24m
    $59–85

  3. Train to Laguardia Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain
    2. Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)planeLGA - BUF
    4h 51m
    $176–1,004

  4. Train to John F. Kennedy International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Poughkeepsie to Grand Central Terminaltrain
    2. Fly from John F. Kennedy International Airport (JFK) to Buffalo Niagara International Airport (BUF)planeJFK - BUF
    5h 11m
    $178–966

  5. Train to Newark Liberty International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain
    2. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)planeEWR - BUF
    5h 42m
    $170–1,132

  6. Train to Laguardia Airport, fly to Rochester, bus

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain
    2. Fly from Laguardia Airport (LGA) to Rochester (ROC)planeLGA - ROC
    3. Take the bus from Rochester, NY to Buffalo, NYbus
    6h 52m
    $186–539

Poughkeepsie to Depew by train and bus

Calendar5Weekly Services
Duration7h 37mAverage Duration
Ticket$54Cheapest Price
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Questions & Answers

What companies run services between Poughkeepsie, NY, USA and Depew, NY, USA?

Amtrak operates a train from Poughkeepsie Amtrak Station to Buffalo Depew Station 4 times a day. Tickets cost $70–130 and the journey takes 6h 34m. VIA Rail also services this route once daily.

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