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How to get fromPoughkeepsie to Depewby train (Amtrak), car, train or plane

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There are 5 ways to get from Poughkeepsie to Depew by train (Amtrak), car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Poughkeepsie Amtrak Station to Buffalo Depew Stationtrain train Maple Leaf / ...
    7h 37m
    $56–112

  2. Drive 322 mi

    1. Drive from Poughkeepsie to Depewcar car 322 mi
    6h 27m
    $59–85

  3. Train to Laguardia Airport, fly

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)plane plane LGA - BUF
    4h 50m
    $166–954

  4. Train to John F. Kennedy International Airport, fly

    1. Take the train from Poughkeepsie to Grand Central Terminaltrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Buffalo Niagara International Airport (BUF)plane plane JFK - BUF
    5h 14m
    $148–816

  5. Train to Newark Liberty International Airport, fly

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane plane EWR - BUF
    5h 46m
    $136–815

Poughkeepsie to Depew by train and bus

Calendar5Weekly Services
Duration7h 37mAverage Duration
Ticket$56Cheapest Price
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Questions & Answers

What companies run services between Poughkeepsie, NY, USA and Depew, NY, USA?

Amtrak operates a train from Poughkeepsie Amtrak Station to Buffalo Depew Station 4 times a day. Tickets cost $80–190 and the journey takes 6h 34m. VIA Rail also services this route once daily.

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