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How to get fromChicago to Depewby plane, train (Amtrak), bus (Greyhound), car or bus

Find Transport to Depew

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There are 7 ways to get from Chicago to Depew by plane, train (Amtrak), bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Buffalo Niagara International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)plane plane ORD - BUF
    3h 36m
    $150–826
  2. Bus

    cheapest
    1. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus Greyhound US0164
    2. Take the bus from Cleveland, OH to Buffalo, NYbus bus Cinncinati,OH-Buffalo
    13h 19m
    $54–142
  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    11h 26m
    $60–201
  4. Drive 536.2 mi

    1. Drive from Chicago to Depewcar car 536.2 mi
    9h 6m
    $98–142
  5. Fly Chicago Midway International Airport to Buffalo Niagara International Airport

    1. Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane plane MDW - BUF
    3h 6m
    $190–1,126
  6. Fly Chicago O'Hare International Airport to Rochester, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Rochester (ROC)plane plane ORD - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus bus
    5h 45m
    $150–571
  7. Fly Chicago Midway International Airport to Rochester, bus

    1. Fly from Chicago Midway International Airport (MDW) to Rochester (ROC)plane plane MDW - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus bus
    5h 16m
    $140–731

Chicago to Depew by train and bus (Amtrak)

Calendar5Weekly Services
Duration11h 26mAverage Duration
Ticket$60Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Depew, NY, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, Amtrak operates a train from Chicago Union Station to Buffalo Depew Station twice daily. Tickets cost $55–200 and the journey takes 10h 23m.

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Bus operators

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