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How to get fromChicago to Depewby plane, train (Amtrak), bus, car, or bus (Greyhound)

Find Transport to Depew

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There are 6 ways to get from Chicago to Depew by plane, train (Amtrak), bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Chicago Midway International Airport

    best
    1. Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane plane MDW - BUF
    3h 8m
    $190–1,026

  2. Bus

    cheapest
    1. Take the bus from Chicago to Clevelandbus bus Chicago
    2. Take the bus from Cleveland, OH to Buffalo, NYbus bus Cinncinati,OH-Buffalo
    13h 3m
    $54–141

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    10h 27m
    $172–342

  4. Drive 535.6 mi

    1. Drive from Chicago to Depewcar car 535.6 mi
    9h 9m
    $98–142

  5. Fly from Chicago O'Hare International Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)plane plane ORD - BUF
    3h 35m
    $140–776

  6. Bus via Brook Park (Greyhound)

    1. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus Greyhound US0164
    2. Take the bus from Cleveland Bus Station to Buffalobus bus Greyhound US0171 / ...
    13h 38m
    $82–157

Chicago to Depew by bus

Calendar7Weekly Buses
Duration13h 3mAverage Duration
Ticket$54Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Depew.ExpandLaunch map view
  • Distance: 482.2 mi
  • Duration: 3h 8m

What companies run services between Chicago, IL, USA and Depew, NY, USA?

Southwest Airlines flies from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF) 3 times a day. Alternatively, Amtrak operates a train from Chicago Union Station to Buffalo Depew Station twice daily. Tickets cost $160–340 and the journey takes 10h 23m.

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