There are 7 ways to get from Chicago to Depew by plane, train (Amtrak), bus (Greyhound), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Chicago Midway International Airport to Buffalo Niagara International Airport
best- Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane MDW - BUF
3h 6m$190–1,126Bus
cheapest- Take the bus from Chicago Bus Station to Cleveland Bus Stationbus Greyhound US0164
- Take the bus from Cleveland, OH to Buffalo, NYbus Cinncinati,OH-Buffalo
13h 19m$54–141Train (Amtrak)
- Take the train from Chicago Union Station to Buffalo Depew Stationtrain Lake Shore Limited
11h 26m$57–169Drive 536.2 mi
- Drive from Chicago to Depewcar 536.2 mi
9h 7m$98–142Fly Chicago O'Hare International Airport to Buffalo Niagara International Airport
- Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)plane ORD - BUF
3h 35m$140–776Fly Chicago Midway International Airport to Rochester, bus
- Fly from Chicago Midway International Airport (MDW) to Rochester (ROC)plane MDW - ROC
- Take the bus from Rochester, NY to Buffalo, NYbus
5h 16m$150–781Fly Chicago O'Hare International Airport to Rochester, bus
- Fly from Chicago O'Hare International Airport (ORD) to Rochester (ROC)plane ORD - ROC
- Take the bus from Rochester, NY to Buffalo, NYbus
5h 42m$200–551
Chicago to Depew by train and bus (Amtrak)
Questions & Answers
The cheapest way to get from Chicago to Depew is to train which costs $55 - $170 and takes 11h 26m.
The fastest way to get from Chicago to Depew is to fly which takes 3h 6m and costs $190 - $1,200.
No, there is no direct bus from Chicago station to Depew. However, there are services departing from Chicago Bus Station and arriving at Broadway & Elwood Avenue via Cleveland, OH and Ellicott Street & MTC Static. The journey, including transfers, takes approximately 13h 19m.
The distance between Chicago and Depew is 484 miles. The road distance is 539.4 miles.
The best way to get from Chicago to Depew without a car is to train which takes 11h 26m and costs $55 - $170.
It takes approximately 3h 6m to get from Chicago to Depew, including transfers.
Chicago to Depew bus services, operated by Greyhound USA, depart from Chicago Bus Station.
The best way to get from Chicago to Depew is to fly which takes 3h 6m and costs $190 - $1,200. Alternatively, you can train, which costs $55 - $170 and takes 11h 26m, you could also bus, which costs $50 - $150 and takes 13h 19m.
Chicago to Depew bus services, operated by Greyhound USA, arrive at Cleveland Bus Station.
Depew is 1h ahead of Chicago. It is currently 5:47 AM in Chicago and 6:47 AM in Depew.
What companies run services between Chicago, IL, USA and Depew, NY, USA?
Southwest Airlines and Delta fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF) 3 times a day. Alternatively, Amtrak operates a train from Chicago Union Station to Buffalo Depew Station twice daily. Tickets cost $55–170 and the journey takes 10h 23m.
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 41m
- When
- Every day
- Estimated price
- $120–750
Flights from Chicago O'Hare International Airport to Rochester
- Ave. Duration
- 1h 48m
- When
- Every day
- Estimated price
- $80–490
Flights from Chicago O'Hare International Airport to Rochester via Philadelphia
- Ave. Duration
- 4h 22m
- When
- Monday, Tuesday, Wednesday, Friday, and Sunday
- Estimated price
- $110–600
- Website
- united.com
Flights from Chicago O'Hare International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 43m
- When
- Every day
- Estimated price
- $120–750
Flights from Chicago O'Hare International Airport to Rochester
- Ave. Duration
- 1h 57m
- When
- Every day
- Estimated price
- $80–490
Flights from Chicago O'Hare International Airport to Rochester via Washington Dulles
- Ave. Duration
- 4h 28m
- When
- Every day
- Estimated price
- $110–600
- Website
- southwest.com
Flights from Chicago Midway International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 29m
- When
- Every day
- Estimated price
- $170–1,100
Flights from Chicago Midway International Airport to Rochester
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- $110–700
Flights from Chicago Midway International Airport to Rochester via Baltimore
- Ave. Duration
- 4h 5m
- When
- Monday, Thursday, Friday, and Saturday
- Estimated price
- $150–850
- Website
- delta.com
Flights from Chicago Midway International Airport to Buffalo Niagara International Airport via Detroit
- Ave. Duration
- 3h 29m
- When
- Monday to Friday
- Estimated price
- $170–1,100
Flights from Chicago O'Hare International Airport to Buffalo Niagara International Airport via Detroit
- Ave. Duration
- 4h 14m
- When
- Every day
- Estimated price
- $120–750
Flights from Chicago Midway International Airport to Rochester via Detroit
- Ave. Duration
- 3h 27m
- When
- Monday to Friday
- Estimated price
- $110–700
Flights from Chicago O'Hare International Airport to Rochester via Detroit
- Ave. Duration
- 4h 2m
- When
- Every day
- Estimated price
- $80–490
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Buffalo Depew Station
- Ave. Duration
- 10h 23m
- Frequency
- Twice daily
- Estimated price
- $55–170
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Chicago Bus Station to Cleveland Bus Station
- Ave. Duration
- 7h 10m
- Frequency
- Twice daily
- Estimated price
- $50–65
- Website
- https://www.greyhound.com/
Bus from Cleveland, OH to Buffalo, NY
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $27–45
- Website
- https://www.greyhound.com/
- Phone
- +1 888-378-3823
- info@baronsbus.com
- Website
- baronsbus.com
Bus from Chicago Bus Station to Cleveland Bus Station
- Ave. Duration
- 6h 55m
- Frequency
- Once daily
- Estimated price
- $30–80
- Website
- https://baronsbus.com
Bus from Cleveland, OH to Buffalo, NY
- Ave. Duration
- 3h 10m
- Frequency
- Once daily
- Estimated price
- $18–60
- Website
- https://baronsbus.com
- Phone
- +1-844-800-6828
- pr@ourbus.com
- Website
- ourbus.com
Bus from Rochester, NY to Buffalo, NY
- Ave. Duration
- 1h
- Frequency
- Once daily
- Estimated price
- $20–55
- Website
- https://www.ourbus.com
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More Questions & Answers
Yes, the driving distance between Chicago to Depew is 539 miles. It takes approximately 9h 7m to drive from Chicago to Depew.
There are 223+ hotels available in Depew.











