There are 5 ways to get from Chicago to Depew by plane, train (Amtrak), bus (Greyhound), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Chicago Midway International Airport
best- Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)MDW - BUF
3h 6m$200–1,126Bus
cheapest- Take the bus from Chicago Bus Station to Cleveland Bus StationGreyhound US0164
- Take the bus from Cleveland, OH to Buffalo, NYCinncinati,OH-Buffalo
13h 19m$54–157Train (Amtrak)
- Take the train from Chicago Union Station to Buffalo Depew StationLake Shore Limited
11h 26m$58–204Drive 536.2 mi
- Drive from Chicago to Depew536.2 mi
9h 1m$98–142Fly from Chicago O'Hare International Airport
- Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)ORD - BUF
3h 36m$170–926
Chicago to Depew by train and bus (Amtrak)
Questions & Answers
The cheapest way to get from Chicago to Depew is to bus which costs $50 - $160 and takes 13h 19m.
The fastest way to get from Chicago to Depew is to fly which takes 3h 6m and costs $200 - $1,200.
No, there is no direct bus from Chicago station to Depew. However, there are services departing from Chicago Bus Station and arriving at Broadway & Elwood Avenue via Cleveland, OH and Ellicott Street & MTC Static. The journey, including transfers, takes approximately 13h 19m.
The distance between Chicago and Depew is 484 miles. The road distance is 539.3 miles.
The best way to get from Chicago to Depew without a car is to train which takes 11h 26m and costs $55 - $210.
It takes approximately 3h 6m to get from Chicago to Depew, including transfers.
Chicago to Depew bus services, operated by Greyhound USA, depart from Chicago Bus Station.
The best way to get from Chicago to Depew is to fly which takes 3h 6m and costs $200 - $1,200. Alternatively, you can train, which costs $55 - $210 and takes 11h 26m, you could also bus, which costs $50 - $160 and takes 13h 19m.
Chicago to Depew bus services, operated by Greyhound USA, arrive at Cleveland Bus Station.
Depew is 1h ahead of Chicago. It is currently 4:23 AM in Chicago and 5:23 AM in Depew.
What companies run services between Chicago, IL, USA and Depew, NY, USA?
Southwest Airlines and Delta fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF) 3 times a day. Alternatively, Amtrak operates a train from Chicago Union Station to Buffalo Depew Station twice daily. Tickets cost $55–210 and the journey takes 10h 23m.
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 47m
- When
- Every day
- Estimated price
- $150–900
Flights from Chicago O'Hare International Airport to Buffalo Niagara International Airport via Reagan Washington
- Ave. Duration
- 4h 15m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $210–1,100
- Website
- southwest.com
Flights from Chicago Midway International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $180–1,100
- Website
- united.com
Flights from Chicago O'Hare International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 47m
- When
- Every day
- Estimated price
- $150–900
- Website
- delta.com
Flights from Chicago Midway International Airport to Buffalo Niagara International Airport via Detroit
- Ave. Duration
- 3h 25m
- When
- Every day
- Estimated price
- $180–1,100
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Buffalo Depew Station
- Ave. Duration
- 10h 23m
- Frequency
- Twice daily
- Estimated price
- $55–210
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Chicago Bus Station to Cleveland Bus Station
- Ave. Duration
- 7h 10m
- Frequency
- Twice daily
- Estimated price
- $40–100
- Website
- https://www.greyhound.com/
Bus from Cleveland, OH to Buffalo, NY
- Ave. Duration
- 3h 50m
- Frequency
- Once daily
- Estimated price
- $26–60
- Website
- https://www.greyhound.com/
- Phone
- +1 888-378-3823
- info@baronsbus.com
- Website
- baronsbus.com
Bus from Chicago Bus Station to Cleveland Bus Station
- Ave. Duration
- 6h 55m
- Frequency
- Once daily
- Estimated price
- $30–80
- Website
- https://baronsbus.com
Bus from Cleveland, OH to Buffalo, NY
- Ave. Duration
- 3h 10m
- Frequency
- Once daily
- Estimated price
- $18–60
- Website
- https://baronsbus.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
Yes, the driving distance between Chicago to Depew is 539 miles. It takes approximately 9h 1m to drive from Chicago to Depew.
There are 223+ hotels available in Depew.