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How to get fromPhiladelphia to Depewby plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus

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There are 7 ways to get from Philadelphia to Depew by plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Philadelphia International Airport

    best
    1. Fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF)plane plane PHL - BUF
    3h 3m
    $100–625

  2. Drive  335.2 mi

    cheapest
    1. Drive from Philadelphia to Depewcar car 335.2 mi
    7h 2m
    $62–89

  3. Train (Amtrak)

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train Keystone Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalo Depew Stationtrain train Empire Service / ...
    11h 28m
    $123–848

  4. Bus

    1. Take the bus from Philadelphia Bus Station to Newark Penn Stationbus bus Greyhound US0421 / ...
    2. Take the bus from Newark Penn Station to Buffalobus bus FlixBus 2686 / ...
    12h 23m
    $74–122

  5. Train to Newark Liberty International Airport, fly

    1. Take the train from 30th Street Station to Newark Liberty International Airporttrain train
    2. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane plane EWR - BUF
    3h 48m
    $106–546

  6. Train to Baltimore-Washington International Airport, fly

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Buffalo Niagara International Airport (BUF)plane plane BWI - BUF
    3h 53m
    $116–1,179

  7. Bus, train

    1. Take the bus from Market St At 13Th St to Wallenberg Ave Across From Terminalbus bus 409
    2. Take the train from Trenton Transit Center to New York Penn Stationtrain train Nec
    3. Take the bus from New York to Buffalobus bus
    15h 34m
    $71–326

Philadelphia to Depew by train and bus (Amtrak)

Calendar5Weekly Services
Duration11h 28mAverage Duration
Ticket$123Cheapest Price
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Comparing Your Travel Options

Map of how to get from Philadelphia to Depew.ExpandLaunch map view
  • Distance: 291.3 mi
  • Duration: 3h 3m

What companies run services between Philadelphia, PA, USA and Depew, NY, USA?

American Airlines and United Airlines fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF) every 3 hours. Alternatively, you can take a train from 30th Street Station to Broadway & Canton Street via Ny Moynihan Train Hall At Penn Station, Buffalo Depew Station, and Broadway & Dick Road in around 11h 28m.

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