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How to get fromPhiladelphia to Depewby plane, train (Amtrak), bus (Flixbus, Greyhound), car, train or bus (Greyhound)

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There are 9 ways to get from Philadelphia to Depew by plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Philadelphia International Airport

    best
    1. Fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF)planePHL - BUF
    2h 52m
    $167–967

  2. Drive 335.2 mi

    cheapest
    1. Drive from Philadelphia to Depewcar335.2 mi
    6h 58m
    $62–89

  3. Train

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn StationtrainNortheast Regional
    2. Take the train from New York Penn Station to BuffalotrainVIA Rail
    11h 39m
    $75–718

  4. Bus

    1. Take the bus from Philadelphia to Newark Penn StationbusFlixBus 2601 / ...
    2. Take the bus from Newark to BuffalobusAdt N816 / ...
    12h 19m
    $70–125

  5. Train to Baltimore-Washington International Airport, fly

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain
    2. Fly from Baltimore-Washington International Airport (BWI) to Buffalo Niagara International Airport (BUF)planeBWI - BUF
    3h 58m
    $162–1,529

  6. Train to Newark Liberty International Airport, fly

    1. Take the train from 30th Street Station to Newark Liberty International Airporttrain
    2. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)planeEWR - BUF
    3h 54m
    $147–1,040

  7. Train to John F. Kennedy International Airport, fly

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain
    2. Fly from John F. Kennedy International Airport (JFK) to Buffalo Niagara International Airport (BUF)planeJFK - BUF
    4h 44m
    $173–1,486

  8. Train via Galleria Driveway & Green Parking Entrance (Amtrak)

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn StationtrainNortheast Regional
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalo Depew StationtrainMaple Leaf / ...
    12h 30m
    $77–750

  9. Bus via Scranton

    1. Take the bus from Philadelphia, PA to Scranton, PAbus202 / ...
    2. Take the bus from Scranton Bus Station to BuffalobusGreyhound US0215
    12h 44m
    $102–166

Philadelphia to Depew by train and bus

Calendar5Weekly Services
Duration11h 39mAverage Duration
Ticket$75Cheapest Price
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Questions & Answers

What companies run services between Philadelphia, PA, USA and Depew, NY, USA?

American Airlines flies from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF) 3 times a day. Alternatively, you can take a train from 30th Street Station to Broadway & Canton Street via Ny Moynihan Train Hall At Penn Station, New York Penn Station, Buffalo, and Broadway & Dick Road in around 11h 39m.

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