Rome2Rio

How to get fromPhiladelphia to Depewby plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, bus or bus (Greyhound)

Find Transport to Depew

See all options

There are 10 ways to get from Philadelphia to Depew by plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Philadelphia International Airport to Buffalo Niagara International Airport

    best
    1. Fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF)plane plane PHL - BUF
    3h 7m
    $165–989

  2. Drive 335.2 mi

    cheapest
    1. Drive from Philadelphia to Depewcar car 335.2 mi
    7h 1m
    $62–89

  3. Train

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train Northeast Regional
    2. Take the train from New York Penn Station to Buffalotrain train VIA Rail
    11h 39m
    $75–718

  4. Bus

    1. Take the bus from Philadelphia to Newark Penn Stationbus bus FlixBus 2601 / ...
    2. Take the bus from Newark Penn Station to Buffalobus bus FlixBus 2686 / ...
    12h 34m
    $69–153

  5. Train to Baltimore-Washington International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Buffalo Niagara International Airport (BUF)plane plane BWI - BUF
    3h 58m
    $157–1,529

  6. Train to Newark Liberty International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from 30th Street Station to Newark Liberty International Airporttrain train
    2. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane plane EWR - BUF
    3h 52m
    $137–1,040

  7. Train to Laguardia Airport, fly to Buffalo Niagara International Airport

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)plane plane LGA - BUF
    5h 16m
    $176–1,583

  8. Fly Philadelphia International Airport to Rochester, bus

    1. Fly from Philadelphia International Airport (PHL) to Rochester (ROC)plane plane PHL - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus bus
    5h 2m
    $184–470

  9. Train via Galleria Driveway & Green Parking Entrance (Amtrak)

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train Northeast Regional
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalo Depew Stationtrain train Maple Leaf / ...
    12h 30m
    $77–750

  10. Bus via Scranton

    1. Take the bus from Philadelphia, PA to Scranton, PAbus bus 202 / ...
    2. Take the bus from Scranton Bus Station to Buffalobus bus Greyhound US0215
    12h 44m
    $102–166

Philadelphia to Depew by train and bus

Calendar5Weekly Services
Duration11h 39mAverage Duration
Ticket$75Cheapest Price
See schedules

Questions & Answers

What companies run services between Philadelphia, PA, USA and Depew, NY, USA?

American Airlines and United Airlines fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF) 5 times a day. Alternatively, you can take a train from 30th Street Station to Broadway & Canton Street via Ny Moynihan Train Hall At Penn Station, New York Penn Station, Buffalo, and Broadway & Dick Road in around 11h 39m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Trips from Philadelphia

Trips to Depew

Popular routes