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How to get fromPhiladelphia to Depewby plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Greyhound)

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There are 8 ways to get from Philadelphia to Depew by plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Philadelphia International Airport

    best
    1. Fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF)plane plane PHL - BUF
    3h 6m
    $170–1,124

  2. Bus

    cheapest
    1. Take the bus from Philadelphia Bus Station to Newark Penn Stationbus bus Greyhound US0421 / ...
    2. Take the bus from Newark Penn Station to Buffalobus bus FlixBus 2686 / ...
    12h 24m
    $62–145

  3. Train (Amtrak)

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train Keystone Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalo Depew Stationtrain train Empire Service / ...
    11h 28m
    $143–868

  4. Drive 335.2 mi

    1. Drive from Philadelphia to Depewcar car 335.2 mi
    7h 2m
    $62–89

  5. Train to Baltimore-Washington International Airport, fly

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Buffalo Niagara International Airport (BUF)plane plane BWI - BUF
    3h 53m
    $161–1,479

  6. Train to Newark Liberty International Airport, fly

    1. Take the train from 30th Street Station to Newark Liberty International Airporttrain train
    2. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane plane EWR - BUF
    3h 47m
    $140–769

  7. Train to Laguardia Airport, fly

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)plane plane LGA - BUF
    5h 17m
    $175–1,533

  8. Bus via Scranton (Greyhound)

    1. Take the bus from Philadelphia Bus Station to Scranton Bus Stationbus bus Greyhound US0340s
    2. Take the bus from Scranton Bus Station to Buffalobus bus Greyhound US0205 / ...
    14h 29m
    $64–124

Philadelphia to Depew by train and bus (Amtrak)

Calendar5Weekly Services
Duration11h 28mAverage Duration
Ticket$143Cheapest Price
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Questions & Answers

Map of how to get from Philadelphia to Depew.ExpandLaunch map view
  • Distance: 291.3 mi
  • Duration: 3h 6m

What companies run services between Philadelphia, PA, USA and Depew, NY, USA?

American Airlines and United Airlines fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF) 5 times a day. Alternatively, you can take a train from 30th Street Station to Broadway & Canton Street via Ny Moynihan Train Hall At Penn Station, Buffalo Depew Station, and Broadway & Dick Road in around 11h 28m.

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