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How to get fromIsernia to Milanby train (Trenitalia), bus, car, train or plane

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There are 10 ways to get from Isernia to Milan by train (Trenitalia), bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Isernia to Roma TerminitrainRe
    2. Take the train from Roma Termini to Milano CentraletrainFr / ...
    5h 44m
    €84–178
  2. Bus

    cheapest
    1. Take the bus from Isernia to Termoli Terminal BusbusCb 014
    2. Take the bus from Termoli Autostazione to Milano, San Donato M3busVieste
    10h 20m
    €41–88
  3. Drive 711.7 km

    1. Drive from Isernia to Milancar711.7 km
    7h 4m
    €110–159
  4. Train to Naples Airport, fly to Milan Linate Airport

    1. Take the train from Isernia to Napoli Centraletrain
    2. Fly from Naples Airport (NAP) to Milan Linate Airport (LIN)planeNAP - LIN
    4h 53m
    €60–190
  5. Train via Milan Rogoredo

    1. Take the train from Isernia to Roma TerminitrainRe
    2. Take the train from Roma Termini to Milan Rogoredotrain9984 / ...
    6h 17m
    €84–178
  6. Train via Milan Rogoredo #2

    1. Take the train from Isernia to Roma TiburtinatrainRe
    2. Take the train from Roma Tiburtina to Milan Rogoredotrain9970 / ...
    6h 18m
    €57–137
  7. Bus via Florence

    1. Take the bus from Isernia to Florence Villa Constanza Bus Stationbus433
    2. Take the bus from Florence Villa Constanza Bus Station to Milano, San Donato M3busN528 / ...
    14h 20m
    €44–113
  8. Train to Fiumicino International Airport, fly to Milan Linate Airport

    1. Take the train from Isernia to Roma Terminitrain
    2. Fly from Fiumicino International Airport (FCO) to Milan Linate Airport (LIN)planeFCO - LIN
    5h 31m
    €88–237
  9. Train to Naples Airport, fly to Il Caravaggio International Airport

    1. Take the train from Isernia to Napoli Centraletrain
    2. Fly from Naples Airport (NAP) to Il Caravaggio International Airport (BGY)planeNAP - BGY
    5h 31m
    €64–232
  10. Train to Naples Airport, fly to Milano Malpensa Airport, train

    1. Take the train from Isernia to Napoli Centraletrain
    2. Fly from Naples Airport (NAP) to Milano Malpensa Airport (MXP)planeNAP - MXP
    3. Take the train from Malpensa Aeroporto T1 to Milano Porta Garibalditrain
    5h 51m
    €47–182

Isernia to Milan by train

Calendar35Weekly Trains
Duration5h 44mAverage Duration
Ticket€84Cheapest Price
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Questions & Answers

What companies run services between Isernia, Italy and Milan, Italy?

You can take a train from Isernia to Milano Centrale via Roma Termini in around 5h 44m. Alternatively, you can take a bus from Isernia to Milano, San Donato M3 via Termoli Autostazione in around 10h 20m.

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Bus operators

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