The average train between Pisa and Mendrisio takes 5h 3m and the fastest train takes 4h 32m. There is a train service every few hours from Pisa to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Pisa and Mendrisio. The earliest departure is at 5:53 AM in the morning, and the last departure from Pisa is at 8:06 PM which arrives into Mendrisio at 6:41 AM. All services require a transfer at Firenze S.M.N. and take an average of 5h 3m. The schedules shown below are for the next available departures.



4h 48m • 3 changes



4h 47m • 3 changes



4h 47m • 3 changes



4h 32m • 3 changes



4h 48m • 3 changes



4h 47m • 3 changes



4h 47m • 3 changes



4h 32m • 3 changes



4h 48m • 3 changes



4h 47m • 3 changes



4h 47m • 3 changes



4h 32m • 3 changes



4h 48m • 3 changes



4h 47m • 3 changes



4h 47m • 3 changes



4h 32m • 3 changes
Want to know about travelling from Pisa to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Pisa to Mendrisio. However, there are services departing from Pisa station and arriving at Mendrisio station via Firenze S.M.N.. The journey, including transfers, takes approximately 5h 3m.
Pisa to Mendrisio train services, operated by Trenitalia, depart from Pisa Centrale station.
Pisa to Mendrisio train services, operated by Trenitalia, arrive at Mendrisio station.
The distance between Pisa and Mendrisio is 265.1 km. The road distance is 440 km.
You can take a train from Pisa Centrale to Mendrisio via Firenze S.M.N., Bologna centrale, and Milano Centrale in around 5h 7m.