The average train between Pisa and Mendrisio takes 5h 31m and the fastest train takes 4h 33m. There is a train service every few hours from Pisa to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Pisa and Mendrisio. The earliest departure is at 4:15 AM at night, and the last departure from Pisa is at 8:32 PM which arrives into Mendrisio at 6:41 AM. All services require a transfer at Firenze S.M.N. and take an average of 5h 31m. The schedules shown below are for the next available departures.


4h 57m • 2 changes


5h 9m • 2 changes


5h 9m • 2 changes


5h 11m • 2 changes


6h 26m • 2 changes


5h 12m • 2 changes


5h 3m • 2 changes


5h 9m • 2 changes


5h 22m • 2 changes


5h 12m • 2 changes


4h 57m • 2 changes


5h 9m • 2 changes


5h 22m • 2 changes


5h 12m • 2 changes


4h 57m • 2 changes


5h 9m • 2 changes
Want to know about travelling from Pisa to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Pisa to Mendrisio. However, there are services departing from Pisa station and arriving at Mendrisio station via Firenze S.M.N.. The journey, including transfers, takes approximately 5h 31m.
Pisa to Mendrisio train services, operated by Trenitalia, depart from Pisa Centrale station.
Pisa to Mendrisio train services, operated by Trenitalia, arrive at Mendrisio station.
The distance between Pisa and Mendrisio is 265.1 km. The road distance is 441 km.
You can take a train from Pisa Centrale to Mendrisio via Firenze S.M.N. and Milano Centrale in around 5h 36m.