Pisa to Mendrisio Trains

Pisa to Mendrisio trains

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Trip Overview

The average train between Pisa and Mendrisio takes 5h 31m and the fastest train takes 4h 32m. There is a train service every few hours from Pisa to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 31m
Duration: 441 km
Distance: CHF 69
Average price: Every 2 hours
Frequency

Train via Florence

best

Take the train from Pisa Centrale to Firenze S.M.N.train Re
Take the train from Firenze S.M.N. to Milano Centraletrain Fr
Take the train from Milano Centrale to Mendrisiotrain

5h 12m

CHF 55–106

Pisa to Mendrisio train times

Trains run every 2 hours between Pisa and Mendrisio. The earliest departure is at 4:15 AM at night, and the last departure from Pisa is at 8:32 PM which arrives into Mendrisio at 6:41 AM. All services require a transfer at Firenze S.M.N. and take an average of 5h 31m. The schedules shown below are for the next available departures.

Departing Thursday, October 15, 2026

8:32 PM → 6:41 AM
Arrives next day
10h 9m • 2 changes

Departing Friday, October 16, 2026

5:19 AM → 10:41 AM
5h 22m • 2 changes
6:29 AM → 11:41 AM
5h 12m • 2 changes
7:44 AM → 12:41 PM
4h 57m • 2 changes
8:32 AM → 1:41 PM
5h 9m • 2 changes
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Departing Saturday, October 17, 2026

5:19 AM → 10:41 AM
5h 22m • 2 changes
6:29 AM → 11:41 AM
5h 12m • 2 changes
7:44 AM → 12:41 PM
4h 57m • 2 changes
8:32 AM → 1:41 PM
5h 9m • 2 changes
Show more

Departing Sunday, October 18, 2026

4:15 AM → 10:41 AM
6h 26m • 2 changes
6:29 AM → 11:41 AM
5h 12m • 2 changes
7:38 AM → 12:41 PM
5h 3m • 2 changes
8:32 AM → 1:41 PM
5h 9m • 2 changes
Show more

Departing Monday, October 19, 2026

5:19 AM → 10:41 AM
5h 22m • 2 changes
6:29 AM → 11:41 AM
5h 12m • 2 changes
7:44 AM → 12:41 PM
4h 57m • 2 changes
8:32 AM → 1:41 PM
5h 9m • 2 changes
Show more

Frequently asked questions

Want to know about travelling from Pisa to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.