Pisa to Mendrisio Trains

Trip Overview

The average train between Pisa and Mendrisio takes 5h 4m and the fastest train takes 4h 32m. There is a train service every few hours from Pisa to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 4m
Duration: 440 km
Distance: CHF 74
Average price: Hourly
Frequency

Train via Bologna

best

Take the train from Pisa Centrale to Firenze S.M.N.train Re
Take the train from Firenze S.M.N. to Bologna Centraletrain Fr
Take the train from Bologna centrale to Milano Centraletrain
Take the train from Milano Centrale to Mendrisiotrain

5h 15m

CHF 58–145

Pisa to Mendrisio train times

Trains run hourly between Pisa and Mendrisio. The earliest departure is at 5:39 AM in the morning, and the last departure from Pisa is at 7:54 PM which arrives into Mendrisio at 6:41 AM. All services require a transfer at Firenze S.M.N. and take an average of 5h 4m. The schedules shown below are for the next available departures.

Departing Wednesday, November 4, 2026

7:54 PM → 6:41 AM
Arrives next day
10h 47m • 3 changes

Departing Thursday, November 5, 2026

5:53 AM → 10:41 AM
4h 48m • 3 changes
6:54 AM → 11:41 AM
4h 47m • 3 changes
7:54 AM → 12:41 PM
4h 47m • 3 changes
9:09 AM → 1:41 PM
4h 32m • 3 changes
Show more

Departing Friday, November 6, 2026

5:53 AM → 10:41 AM
4h 48m • 3 changes
6:54 AM → 11:41 AM
4h 47m • 3 changes
7:54 AM → 12:41 PM
4h 47m • 3 changes
9:09 AM → 1:41 PM
4h 32m • 3 changes
Show more

Departing Saturday, November 7, 2026

5:53 AM → 10:41 AM
4h 48m • 3 changes
6:29 AM → 11:41 AM
5h 12m • 3 changes
7:54 AM → 12:41 PM
4h 47m • 3 changes
9:09 AM → 1:41 PM
4h 32m • 3 changes
Show more

Departing Sunday, November 8, 2026

5:39 AM → 10:41 AM
5h 2m • 3 changes
6:29 AM → 11:41 AM
5h 12m • 3 changes
7:54 AM → 12:41 PM
4h 47m • 3 changes
9:09 AM → 1:41 PM
4h 32m • 3 changes
Show more

Departing Monday, November 9, 2026

5:53 AM → 10:41 AM
4h 48m • 3 changes
6:54 AM → 11:41 AM
4h 47m • 3 changes
7:54 AM → 12:41 PM
4h 47m • 3 changes
9:09 AM → 1:41 PM
4h 32m • 3 changes
Show more

Departing Tuesday, November 10, 2026

5:53 AM → 10:41 AM
4h 48m • 3 changes
6:54 AM → 11:41 AM
4h 47m • 3 changes
7:54 AM → 12:41 PM
4h 47m • 3 changes
9:09 AM → 1:41 PM
4h 32m • 3 changes
Show more

Frequently asked questions

Want to know about travelling from Pisa to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.