There are 7 ways to get from Pisa to Mendrisio by train (Trenitalia), bus, car, plane, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train via Bologna
best- Take the train from Pisa Centrale to Firenze S.M.N.train Re
- Take the train from Firenze S.M.N. to Bologna Centraletrain Fr
- Take the train from Bologna centrale to Milano Centraletrain
- Take the train from Milano Centrale to Mendrisiotrain
5h 15mCHF 58–145Bus, train
cheapest- Take the bus from Pisa to Milanbus N1508
- Take the train from Monza to Mendrisiotrain Re80 / ...
8h 35mCHF 37–57Bus
- Take the bus from Pisa to Florence Villa Constanza Bus Stationbus 443 / ...
- Take the bus from Florence Villa Constanza Bus Station to Comobus
6h 40mCHF 66–98Drive 337.8 km
- Drive from Pisa to Mendrisiocar 337.8 km
3h 36mCHF 65–93Fly Pisa International Airport to Milan Linate Airport, train
- Fly from Pisa International Airport (PSA) to Milan Linate Airport (LIN)plane PSA - LIN
- Take the train from Monza to Mendrisiotrain
5h 34mCHF 117–256Train
- Take the train from Pisa Centrale to Chiassotrain Ec
7h 16mCHF 72–167Bus to Florence Peretola Airport, fly to Milano Malpensa Airport, train
- Take the bus from Pisa International Airport to Florence Airportbus
- Fly from Florence Peretola Airport (FLR) to Milano Malpensa Airport (MXP)plane FLR - MXP
- Take the train from Malpensa Aeroporto T1 to Mendrisiotrain
6h 59mCHF 126–288
Pisa to Mendrisio by train
Comparing Your Travel Options
The cheapest way to get from Pisa to Mendrisio is to bus and train which costs SFr 35 - SFr 60 and takes 8h 35m.
The fastest way to get from Pisa to Mendrisio is to drive which takes 3h 36m and costs SFr 60 - SFr 95.
No, there is no direct bus from Pisa to Mendrisio. However, there are services departing from Pisa and arriving at Mendrisio, Autosilo via Florence Villa Constanza Bus Station, Como - Chiesa di San Zenone and Chiasso, Stazione. The journey, including transfers, takes approximately 6h 40m.
No, there is no direct train from Pisa to Mendrisio. However, there are services departing from Pisa Centrale and arriving at Mendrisio via Firenze S.M.N., Bologna centrale and Milano Centrale. The journey, including transfers, takes approximately 5h 15m.
The distance between Pisa and Mendrisio is 440 km. The road distance is 337.8 km.
The best way to get from Pisa to Mendrisio without a car is to train via Bologna which takes 5h 15m and costs SFr 55 - SFr 150.
It takes approximately 5h 15m to get from Pisa to Mendrisio, including transfers.
Pisa to Mendrisio bus services, operated by FlixBus, depart from Pisa station.
Pisa to Mendrisio train services, operated by Trenitalia, depart from Pisa Centrale station.
The best way to get from Pisa to Mendrisio is to train via Bologna which takes 5h 15m and costs SFr 55 - SFr 150. Alternatively, you can bus, which costs SFr 65 - SFr 100 and takes 6h 40m.
What companies run services between Pisa, Italy and Mendrisio, Switzerland?
You can take a train from Pisa Centrale to Mendrisio via Firenze S.M.N., Bologna centrale, and Milano Centrale in around 5h 15m. Alternatively, you can take a bus from Pisa to Mendrisio, Autosilo via Florence Villa Constanza Bus Station, Como, Como - Chiesa di San Zenone, and Chiasso, Stazione in around 6h 40m.
- Website
- ita-airways.com
Flights from Pisa International Airport to Milan Linate Airport via Bari
- Ave. Duration
- 3h 52m
- When
- Friday and Thursday
- Estimated price
- CHF 130–210
Flights from Pisa International Airport to Milan Linate Airport via Alghero
- Ave. Duration
- 3h 45m
- When
- Friday and Sunday
- Estimated price
- CHF 130–210
Flights from Florence Peretola Airport to Milano Malpensa Airport via Munich
- Ave. Duration
- 4h 1m
- When
- Every day
- Estimated price
- CHF 140–430
Flights from Florence Peretola Airport to Milano Malpensa Airport via Zurich
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- CHF 70–270
- Website
- airdolomiti.it
Flights from Pisa International Airport to Milan Linate Airport via Frankfurt
- Ave. Duration
- 7h 40m
- When
- Sunday
- Estimated price
- CHF 160–500
Flights from Florence Peretola Airport to Milano Malpensa Airport via Munich
- Ave. Duration
- 4h 1m
- When
- Every day
- Estimated price
- CHF 140–430
- Website
- swiss.com
Flights from Florence Peretola Airport to Milano Malpensa Airport via Zurich
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- CHF 70–270
- Website
- easyjet.com
Flights from Pisa International Airport to Milan Linate Airport via Paris Orly
- Ave. Duration
- 4h 10m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- CHF 70–350
- Website
- aeroitalia.com
Flights from Pisa International Airport to Milan Linate Airport via Cagliari
- Ave. Duration
- 3h 20m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- CHF 100–230
- Website
- ryanair.com
Flights from Florence Peretola Airport to Milano Malpensa Airport via Alghero
- Ave. Duration
- 3h 40m
- When
- Sunday
- Estimated price
- CHF 100–240
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Pisa Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 22m
- Frequency
- Every 30 minutes
- Estimated price
- CHF 8–12
- Website
- Trenitalia
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 28m
- Frequency
- Twice daily
- Estimated price
- CHF 10–14
- Website
- Trenitalia
- Phone
- +39 06 5210550
- Website
- Trenitalia Frecce
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 37 min
- Frequency
- Hourly
- Estimated price
- CHF 11–20
- Website
- Trenitalia Frecce
- Phone
- +39 06 8937 1892
- Website
- Italo Treno
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 45 min
- Frequency
- 4 times a day
- Estimated price
- CHF 9–16
- Website
- Italo Treno
Train from Bologna centrale to Milano Centrale
- Ave. Duration
- 1h 4m
- Frequency
- Every 30 minutes
- Estimated price
- CHF 23–40
- Website
- Italo Treno
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- Trenitalia Eurocity
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 12m
- Frequency
- Once daily
- Estimated price
- CHF 24–65
- Website
- Trenitalia Eurocity
- 1st Class
- CHF 45–65
- 2nd Class
- CHF 24–35
Train from Pisa Centrale to Chiasso
- Ave. Duration
- 6h 36m
- Frequency
- Twice a week
- Estimated price
- CHF 70–120
- Website
- Trenitalia Eurocity
- 1st Class
- CHF 80–120
- 2nd Class
- CHF 70–95
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 17m
- Frequency
- Once daily
- Estimated price
- CHF 9–17
- Website
- Trenitalia Intercity
Train from Milano Centrale to Mendrisio
- Ave. Duration
- 58 min
- Frequency
- Hourly
- Estimated price
- CHF 17–28
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Pisa Centrale to Chiasso
- Ave. Duration
- 6h 36m
- Frequency
- Twice a week
- Estimated price
- CHF 100–170
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Malpensa Aeroporto T1 to Mendrisio
- Ave. Duration
- 1h 8m
- Frequency
- Hourly
- Estimated price
- CHF 17–28
- Website
- Swiss Federal Railways (SBB CFF FFS)
- Phone
- +39 02 7249 4494
- my-link@trenord.it
- Website
- Trenord
Train from Monza to Mendrisio
- Ave. Duration
- 48 min
- Frequency
- Hourly
- Estimated price
- CHF 2–4
- Website
- Trenord
Train from Monza to Mendrisio
- Ave. Duration
- 48 min
- Frequency
- Hourly
- Estimated price
- CHF 2–4
- Website
- Trenord
Train from Malpensa Aeroporto T1 to Mendrisio
- Ave. Duration
- 1h 8m
- Frequency
- Hourly
- Estimated price
- CHF 4–6
- Website
- Trenord
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- Flixbus
Bus from Pisa to Florence Villa Constanza Bus Station
- Ave. Duration
- 1h 35m
- Frequency
- 3 times a day
- Estimated price
- CHF 7–12
- Website
- Flixbus
Bus from Pisa to Milan
- Ave. Duration
- 7h
- Frequency
- 6 times a week
- Estimated price
- CHF 30–55
- Website
- Flixbus
- Phone
- +39 0362 185 0590
- info@onebus.it
- Website
- Onebus
Bus from Florence Villa Constanza Bus Station to Como
- Ave. Duration
- 3h 7m
- Frequency
- Once a week
- Estimated price
- CHF 55–80
- Website
- Onebus
- Phone
- +352 50 55 62 63 10
- info@flibco.com
- Website
- Flibco
Bus from Pisa International Airport to Florence Airport
- Ave. Duration
- 1h
- Frequency
- Hourly
- Estimated price
- CHF 11–20
- Website
- Flibco
Want to know more about travelling around Switzerland
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Booking & Getting There
Pisa to Mendrisio bus services, operated by FlixBus, arrive at Florence Villa Constanza Bus Station.
Pisa to Mendrisio train services, operated by Trenitalia, arrive at Firenze S.M.N. station.
Yes, the driving distance between Pisa to Mendrisio is 338 km. It takes approximately 3h 36m to drive from Pisa to Mendrisio.
There are 5133+ hotels available in Mendrisio.





































