Train Rome to Mendrisio from CHF 106 | Tickets & Timetables

Trip Overview

The average train between Rome and Mendrisio takes 4h 59m and the fastest train takes 4h 31m. There is a train service every few hours from Rome to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 59m
Duration: 639 km
Distance: CHF 106
Average price: Hourly
Frequency

Train

best

Take the train from Roma Termini to Milano Centraletrain 9950 / ...
Take the train from Milano Centrale to Mendrisiotrain Re80

4h 39m

CHF 89–192

Rome to Mendrisio train times

Trains run hourly between Rome and Mendrisio. The earliest departure is at 5:40 AM in the morning, and the last departure from Rome is at 8:05 PM which arrives into Mendrisio at 6:41 AM. All services require a transfer, and take on average 4h 59m. The schedules shown below are for the next available departures.

Departing Wednesday, May 6, 2026

5:40 AM → 10:41 AM
5h 1m • 1 change
7:05 AM → 11:41 AM
4h 36m • 1 change
8:05 AM → 12:41 PM
4h 36m • 1 change
9:05 AM → 1:41 PM
4h 36m • 1 change
Show more

Departing Thursday, May 7, 2026

5:40 AM → 10:41 AM
5h 1m • 1 change
7:05 AM → 11:41 AM
4h 36m • 1 change
8:05 AM → 12:41 PM
4h 36m • 1 change
9:05 AM → 1:41 PM
4h 36m • 1 change
Show more

Departing Friday, May 8, 2026

5:40 AM → 10:41 AM
5h 1m • 1 change
7:05 AM → 11:41 AM
4h 36m • 1 change
8:05 AM → 12:41 PM
4h 36m • 1 change
9:05 AM → 1:41 PM
4h 36m • 1 change
Show more

Departing Saturday, May 9, 2026

5:40 AM → 10:41 AM
5h 1m • 1 change
7:05 AM → 11:41 AM
4h 36m • 1 change
8:05 AM → 12:41 PM
4h 36m • 1 change
9:05 AM → 1:41 PM
4h 36m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Rome to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.