Rome to Mendrisio Trains

Rome to Mendrisio trains

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Trip Overview

The average train between Rome and Mendrisio takes 5h 3m and the fastest train takes 4h 31m. The train service runs several times per day from Rome to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 3m
Duration: 639 km
Distance: CHF 105
Average price: Every 2 hours
Frequency

Train

best

Take the train from Roma Termini to Milano Centraletrain 9950 / ...
Take the train from Milano Centrale to Mendrisiotrain Re80

4h 39m

CHF 89–201

Rome to Mendrisio train times

Trains run every 2 hours between Rome and Mendrisio. The earliest departure is at 7:05 AM in the morning, and the last departure from Rome is at 8:05 PM which arrives into Mendrisio at 6:41 AM. All services require a transfer, and take on average 5h 3m. The schedules shown below are for the next available departures.

Departing Sunday, August 16, 2026

7:05 AM → 11:41 AM
4h 36m • 1 change
9:05 AM → 1:41 PM
4h 36m • 1 change
11:05 AM → 3:41 PM
4h 36m • 1 change
12:10 PM → 4:41 PM
4h 31m • 1 change
Show more

Departing Monday, August 17, 2026

7:05 AM → 11:41 AM
4h 36m • 1 change
9:05 AM → 1:41 PM
4h 36m • 1 change
11:05 AM → 3:41 PM
4h 36m • 1 change
12:10 PM → 4:41 PM
4h 31m • 1 change
Show more

Departing Tuesday, August 18, 2026

7:05 AM → 11:41 AM
4h 36m • 1 change
9:05 AM → 1:41 PM
4h 36m • 1 change
11:05 AM → 3:41 PM
4h 36m • 1 change
12:10 PM → 4:41 PM
4h 31m • 1 change
Show more

Departing Wednesday, August 19, 2026

7:05 AM → 11:41 AM
4h 36m • 1 change
9:05 AM → 1:41 PM
4h 36m • 1 change
11:05 AM → 3:41 PM
4h 36m • 1 change
12:10 PM → 4:41 PM
4h 31m • 1 change
Show more

Departing Thursday, August 20, 2026

7:05 AM → 11:41 AM
4h 36m • 1 change
9:05 AM → 1:41 PM
4h 36m • 1 change
11:05 AM → 3:41 PM
4h 36m • 1 change
12:10 PM → 4:41 PM
4h 31m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Rome to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.