The train between Milan and Mendrisio takes 1h 20m. There is a train service every few hours from Milan to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Milan and Mendrisio. The earliest departure is at 7:10 AM in the morning, and the last departure from Milan is at 8:10 PM which arrives into Mendrisio at 9:30 PM. All services require a transfer, and take on average 1h 20m. The schedules shown below are for the next available departures.

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Want to know about travelling from Milan to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milan to Mendrisio. However, there are services departing from Milan station and arriving at Mendrisio station via Chiasso. The journey, including transfers, takes approximately 1h 20m.
Milan to Mendrisio train services, operated by Trenitalia EuroCity, depart from Milano Centrale station.
Milan to Mendrisio train services, operated by Trenitalia EuroCity, arrive at Chiasso station.
Book your Milan to Mendrisio train tickets online with Trenitalia EuroCity, Swiss Federal Railways (SBB CFF FFS) and Trenitalia.
The distance between Milan and Mendrisio is 47.9 km. The road distance is 54 km.
Trenitalia EuroCity operates a train from Milano Centrale to Chiasso hourly. Tickets cost CHF 17–55 and the journey takes 48 min. Trenitalia also services this route once daily.