The average train between Mainz and Amsterdam takes 4h 49m and the fastest train takes 4h 15m. The train service runs several times per day from Mainz to Amsterdam. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mainz and Amsterdam. The earliest departure is at 2:04 AM at night, and the last departure from Mainz is at 11:14 PM which arrives into Amsterdam at 8:59 AM. All services require a transfer at Frankfurt and take an average of 4h 49m. The schedules shown below are for the next available departures.

4h 23m • 1 change

4h 16m • 1 change

4h 15m • 1 change

4h 15m • 1 change

6h 55m • 1 change

4h 23m • 1 change

4h 16m • 1 change

4h 15m • 1 change

6h 55m • 1 change

4h 20m • 1 change

4h 16m • 1 change

4h 15m • 1 change

4h 15m • 1 change

4h 15m • 1 change

4h 15m • 1 change

4h 15m • 1 change

4h 15m • 1 change

4h 15m • 1 change

4h 15m • 1 change

4h 15m • 1 change

4h 23m • 1 change

4h 16m • 1 change

4h 15m • 1 change

4h 15m • 1 change

6h 55m • 1 change

4h 23m • 1 change

4h 16m • 1 change

4h 15m • 1 change
Want to know about travelling from Mainz to Amsterdam? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Amsterdam. However, there are services departing from Mainz station and arriving at Amsterdam station via Amsterdam Centraal. The journey, including transfers, takes approximately 4h 49m.
Mainz to Amsterdam train services, operated by vlexx, depart from Frankfurt Flughafen Fernb station.
Mainz to Amsterdam train services, operated by vlexx, arrive at Amsterdam Centraal station.
Book your Mainz to Amsterdam train tickets online with vlexx, Nederlandse Spoorwegen (NS) and Deutsche Bahn Regio (DB Regional).
The distance between Mainz and Amsterdam is 355.5 km. The road distance is 452 km.
Nederlandse Spoorwegen (NS) operates a train from Frankfurt Flughafen Fernb to Amsterdam Centraal every 3 hours. Tickets cost €45–100 and the journey takes 3h 41m.