The average train between Mainz and Lucerne takes 5h 22m and the fastest train takes 4h 19m. The train service runs several times per day from Mainz to Lucerne. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Mainz and Lucerne. The earliest departure is at 5:40 AM in the morning, and the last departure from Mainz is at 11:08 PM which arrives into Lucerne at 10:05 AM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 5h 22m. The schedules shown below are for the next available departures.


4h 25m • 2 changes


4h 19m • 2 changes


4h 52m • 2 changes


4h 48m • 2 changes


4h 25m • 2 changes


4h 19m • 2 changes


4h 52m • 2 changes


4h 48m • 2 changes


4h 19m • 2 changes


4h 52m • 2 changes


4h 48m • 2 changes


4h 52m • 2 changes


4h 25m • 2 changes


4h 19m • 2 changes


4h 52m • 2 changes


4h 48m • 2 changes


4h 25m • 2 changes


4h 19m • 2 changes


4h 52m • 2 changes


4h 48m • 2 changes
Want to know about travelling from Mainz to Lucerne? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Lucerne. However, there are services departing from Mainz station and arriving at Lucerne station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 5h 22m.
Mainz to Lucerne train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mainz, Hauptbahnhof station.
Mainz to Lucerne train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Luzern station.
Book your Mainz to Lucerne train tickets online with Deutsche Bahn Intercity (DB IC), Swiss Federal Railways (SBB CFF FFS) and 3 other operators.
The distance between Mainz and Lucerne is 326.2 km. The road distance is 415 km.
You can take a train from Mainz, Hauptbahnhof to Luzern via Mannheim, Hauptbahnhof and Basel SBB in around 4h 58m.