The average train between Mainz and Zurich takes 5h 38m and the fastest train takes 4h 18m. There is a train service every few hours from Mainz to Zurich. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mainz and Zurich. The earliest departure is at 1:38 AM at night, and the last departure from Mainz is at 11:08 PM which arrives into Zurich at 7:26 AM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 5h 38m. The schedules shown below are for the next available departures.


4h 22m • 2 changes


5h 38m • 2 changes


5h 38m • 2 changes


5h 14m • 2 changes


5h 48m • 2 changes


7h 9m • 2 changes


4h 22m • 2 changes


5h 38m • 2 changes


5h 48m • 2 changes


6h 43m • 2 changes


5h 38m • 2 changes


6h 2m • 2 changes


4h 22m • 2 changes


5h 38m • 2 changes


5h 38m • 2 changes


5h 14m • 2 changes
Want to know about travelling from Mainz to Zurich? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Zurich. However, there are services departing from Mainz station and arriving at Zurich station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 5h 38m.
Mainz to Zurich train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Hauptbahnhof station.
Mainz to Zurich train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Zürich HB station.
Book your Mainz to Zurich train tickets online with Deutsche Bahn Regio (DB Regional), Nederlandse Spoorwegen (NS) and 3 other operators.
The distance between Mainz and Zurich is 291.7 km. The road distance is 411 km.
You can take a train from Mainz, Hauptbahnhof to Zürich HB via Mannheim, Hauptbahnhof and Basel SBB in around 4h 44m.