The average train between Mainz and Kassel takes 2h 40m and the fastest train takes 2h 24m. There is an hourly train service from Mainz to Kassel. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mainz and Kassel. The earliest departure is at 3:04 AM at night, and the last departure from Mainz is at 10:10 PM which arrives into Kassel at 6:10 AM. All services require a transfer, and take on average 2h 40m. The schedules shown below are for the next available departures.

2h 38m • 1 change

2h 37m • 1 change

2h 30m • 1 change

2h 37m • 1 change

2h 37m • 1 change

2h 30m • 1 change

2h 34m • 1 change

2h 24m • 1 change

3h 6m • 1 change

3h 2m • 1 change

2h 30m • 1 change

2h 34m • 1 change
Want to know about travelling from Mainz to Kassel? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Kassel. However, there are services departing from Mainz station and arriving at Kassel station via Frankfurt. The journey, including transfers, takes approximately 2h 40m.
Mainz to Kassel train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Römisches Theater station.
Mainz to Kassel train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Kassel Bahnhof Wilhelmshöhe station.
Book your Mainz to Kassel train tickets online with Deutsche Bahn Regio (DB Regional), Deutsche Bahn Intercity (DB IC) and 2 other operators.
The distance between Mainz and Kassel is 171.3 km. The road distance is 229 km.
You can take a train from Mainz, Römisches Theater to Kassel Bahnhof Wilhelmshöhe via Frankfurt in around 2h 19m.