The average train between Mainz and Berlin takes 4h 58m and the fastest train takes 4h 40m. There is a train service every few hours from Mainz to Berlin. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mainz and Berlin. The earliest departure is at 2:04 AM at night, and the last departure from Mainz is at 7:14 PM which arrives into Berlin at 12:30 AM. All services require a transfer, and take on average 4h 58m. The schedules shown below are for the next available departures.

4h 50m • 1 change

4h 47m • 1 change

4h 40m • 1 change

5h 16m • 1 change

6h 17m • 1 change

5h 21m • 1 change

4h 40m • 1 change

4h 48m • 1 change

6h 2m • 1 change

5h 21m • 1 change

4h 40m • 1 change

4h 48m • 1 change

6h 2m • 1 change

5h 21m • 1 change

4h 40m • 1 change

4h 48m • 1 change
Want to know about travelling from Mainz to Berlin? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Berlin. However, there are services departing from Mainz station and arriving at Berlin station via Berlin Hbf. The journey, including transfers, takes approximately 4h 58m.
Mainz to Berlin train services, operated by Süwex, depart from Frankfurt station.
Mainz to Berlin train services, operated by Süwex, arrive at Berlin Hbf station.
Book your Mainz to Berlin train tickets online with Süwex, Deutsche Bahn Intercity (DB IC) and 2 other operators.
The distance between Mainz and Berlin is 455.1 km. The road distance is 577 km.
Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Berlin Hbf hourly. Tickets cost €100–240 and the journey takes 4h 15m.