The average train between Lyon and Mainz takes 8h 54m and the fastest train takes 6h 14m. The train service runs several times per day from Lyon to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Lyon and Mainz. The earliest departure is at 8:32 AM in the morning, and the last departure from Lyon is at 6:00 PM which arrives into Mainz at 11:18 AM. All services require a transfer at Strasbourg and take an average of 8h 54m. The schedules shown below are for the next available departures.


6h 14m • 2 changes


7h 40m • 2 changes
Arrives next day


17h 18m • 2 changes


6h 46m • 2 changes


6h 42m • 2 changes


7h 40m • 2 changes
Arrives next day


9h 21m • 2 changes


6h 46m • 2 changes


6h 42m • 2 changes


6h 46m • 2 changes
Arrives next day


17h 18m • 2 changes


6h 46m • 2 changes


6h 14m • 2 changes


7h 40m • 2 changes
Arrives next day


17h 18m • 2 changes


6h 46m • 2 changes


6h 14m • 2 changes


7h 40m • 2 changes
Arrives next day


17h 18m • 2 changes
Want to know about travelling from Lyon to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Lyon to Mainz. However, there are services departing from Lyon station and arriving at Mainz station via Strasbourg. The journey, including transfers, takes approximately 8h 54m.
Lyon to Mainz train services, operated by TGV inOui, depart from Lyon Part Dieu station.
Lyon to Mainz train services, operated by TGV inOui, arrive at Mainz, Hauptbahnhof station.
Book your Lyon to Mainz train tickets online with TGV inOui, Deutsche Bahn Intercity (DB IC) and 2 other operators.
The distance between Lyon and Mainz is 535.9 km. The road distance is 712 km.
You can take a train from Lyon Part Dieu to Mainz, Hauptbahnhof via Strasbourg, Mannheim Hbf, and Mannheim, Hauptbahnhof in around 7h 13m.