The average train between Isernia and Lugano takes 9h 15m and the fastest train takes 7h 20m. The train service runs several times per day from Isernia to Lugano. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Isernia and Lugano. The earliest departure is at 6:35 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Lugano at 11:02 AM. All services require a transfer at Roma Termini and take an average of 9h 15m. The schedules shown below are for the next available departures.


7h 20m • 2 changes


8h 1m • 2 changes
Arrives next day


14h 27m • 2 changes


7h 23m • 2 changes


7h 20m • 2 changes


7h 45m • 2 changes
Arrives next day


13h 31m • 2 changes


7h 23m • 2 changes


7h 20m • 2 changes


8h 1m • 2 changes
Arrives next day


14h 27m • 2 changes


7h 23m • 2 changes


7h 20m • 2 changes


8h 1m • 2 changes
Arrives next day


14h 27m • 2 changes


7h 23m • 2 changes


7h 20m • 2 changes


8h 1m • 2 changes
Arrives next day


14h 27m • 2 changes
Want to know about travelling from Isernia to Lugano? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Lugano. However, there are services departing from Isernia station and arriving at Lugano station via Roma Termini. The journey, including transfers, takes approximately 9h 15m.
Isernia to Lugano train services, operated by Trenitalia, depart from Isernia station.
Isernia to Lugano train services, operated by Trenitalia, arrive at Lugano station.
Book your Isernia to Lugano train tickets online with Trenitalia, ItaloTreno and Trenord.
The distance between Isernia and Lugano is 647.8 km. The road distance is 843 km.
You can take a train from Isernia to Lugano via Roma Termini and Milano Centrale in around 7h 37m.