The average train between Essen and Mainz takes 2h 22m and the fastest train takes 2h 8m. There is an hourly train service from Essen to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Essen and Mainz. The earliest departure is at 4:30 AM at night, and the last departure from Essen is at 11:00 PM which arrives into Mainz at 1:23 AM. All services require a transfer, and take on average 2h 22m. The schedules shown below are for the next available departures.

2h 8m • 1 change

2h 24m • 1 change

2h 20m • 1 change

2h 8m • 1 change

2h 53m • 1 change

2h 44m • 1 change

2h 24m • 1 change

2h 20m • 1 change

2h 52m • 1 change

2h 8m • 1 change

2h 23m • 1 change

2h 19m • 1 change
Want to know about travelling from Essen to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Essen to Mainz. However, there are services departing from Essen station and arriving at Mainz station via Frankfurt. The journey, including transfers, takes approximately 2h 22m.
Essen to Mainz train services, operated by Deutsche Bahn Intercity (DB IC), depart from Essen Hbf station.
Essen to Mainz train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Frankfurt station.
Book your Essen to Mainz train tickets online with Deutsche Bahn Intercity (DB IC), vlexx and Deutsche Bahn Regio (DB Regional).
The distance between Essen and Mainz is 186.4 km. The road distance is 275 km.
Deutsche Bahn Intercity (DB IC) operates a train from Essen Hbf to Frankfurt hourly. Tickets cost €45–130 and the journey takes 1h 49m.