The average train between Agen and Siena takes 28h 15m and the fastest train takes 25h 53m. There is at least one train per day from Agen to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run once daily between Agen and Siena. The earliest departure is at 5:41 AM in the morning, and the last departure from Agen is at 11:43 PM which arrives into Siena at 9:38 AM. All services require a transfer at Toulouse Matabiau and take an average of 28h 15m. The schedules shown below are for the next available departures.
Arrives next day




27h 57m • 4 changes
Arrives next day




26h 13m • 4 changes
Arrives next day




27h 57m • 4 changes
Arrives next day




26h 13m • 4 changes
Want to know about travelling from Agen to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Agen to Siena. However, there are services departing from Agen station and arriving at Siena station via Toulouse Matabiau. The journey, including transfers, takes approximately 28h 15m.
Agen to Siena train services, operated by Société Nationale des Chemins de fer Français (SNCF), depart from Agen station.
Agen to Siena train services, operated by Société Nationale des Chemins de fer Français (SNCF), arrive at Siena station.
Book your Agen to Siena train tickets online with Société Nationale des Chemins de fer Français (SNCF), TGV inOui and 2 other operators.
The distance between Agen and Siena is 865.1 km. The road distance is 1,517 km.
You can take a train from Agen to Siena via Toulouse Matabiau, Lyon Part Dieu, Milano Centrale, and Firenze S.M.N. in around 17h 12m.