The average train between Genoa and Siena takes 4h 45m and the fastest train takes 3h 42m. The train service runs several times per day from Genoa to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Genoa and Siena. The earliest departure is at 5:14 AM in the morning, and the last departure from Genoa is at 8:56 PM which arrives into Siena at 7:47 AM. All services require a transfer at Pisa Centrale and take an average of 4h 45m. The schedules shown below are for the next available departures.


3h 45m • 2 changes


4h 17m • 2 changes


4h 42m • 2 changes


4h 14m • 2 changes


3h 45m • 2 changes


4h 17m • 2 changes


4h 42m • 2 changes


4h 14m • 2 changes


3h 43m • 2 changes


4h 42m • 2 changes


4h 39m • 2 changes


4h 20m • 2 changes


3h 43m • 2 changes


3h 43m • 2 changes


4h 28m • 2 changes


4h 42m • 2 changes


4h 24m • 2 changes


4h 42m • 2 changes


4h 39m • 2 changes


4h 20m • 2 changes
Want to know about travelling from Genoa to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Genoa to Siena. However, there are services departing from Genoa station and arriving at Siena station via Pisa Centrale. The journey, including transfers, takes approximately 4h 45m.
Genoa to Siena train services, operated by Trenitalia Frecce, depart from Genova Brignole station.
Genoa to Siena train services, operated by Trenitalia Frecce, arrive at Siena station.
Book your Genoa to Siena train tickets online with Trenitalia Frecce, Trenitalia and Trenitalia Intercity.
The distance between Genoa and Siena is 226.3 km. The road distance is 268 km.
You can take a train from Genova Brignole to Siena via Pisa Centrale and Empoli in around 4h 15m.