The average train between Genoa and Siena takes 4h 40m and the fastest train takes 3h 42m. There is a train service every few hours from Genoa to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Genoa and Siena. The earliest departure is at 5:55 AM in the morning, and the last departure from Genoa is at 8:56 PM which arrives into Siena at 7:31 AM. All services require a transfer at Pisa Centrale and take an average of 4h 40m. The schedules shown below are for the next available departures.


4h 42m • 2 changes


4h 14m • 2 changes


4h 2m • 2 changes


4h 7m • 2 changes


3h 43m • 2 changes


3h 43m • 2 changes


4h 28m • 2 changes


4h 42m • 2 changes


3h 43m • 2 changes


3h 43m • 2 changes


4h 28m • 2 changes


4h 42m • 2 changes


3h 43m • 2 changes


3h 43m • 2 changes


4h 28m • 2 changes


4h 42m • 2 changes


3h 43m • 2 changes


3h 43m • 2 changes


4h 28m • 2 changes


4h 42m • 2 changes
Want to know about travelling from Genoa to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Genoa to Siena. However, there are services departing from Genoa station and arriving at Siena station via Pisa Centrale. The journey, including transfers, takes approximately 4h 40m.
Genoa to Siena train services, operated by Trenitalia Intercity, depart from Genova Brignole station.
Genoa to Siena train services, operated by Trenitalia Intercity, arrive at Siena station.
Book your Genoa to Siena train tickets online with Trenitalia Intercity, Trenitalia and Trenitalia Frecce.
The distance between Genoa and Siena is 226.3 km. The road distance is 268 km.
You can take a train from Genova Brignole to Siena via Pisa Centrale and Empoli in around 4h 15m.