The bus between St. Louis and Buffalo takes 19h 40m. There is at least one bus per day from St. Louis to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between St. Louis and Buffalo. The earliest departure is at 2:00 AM at night, and the last departure from St. Louis is at 2:00 AM which arrives into Buffalo at 10:40 PM. All services require a transfer at Indianapolis, IN and take an average of 19h 40m. The schedules shown below are for the next available departures.
Want to know about travelling from St. Louis to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from St. Louis to Buffalo. However, there are services departing from St. Louis station and arriving at Buffalo station via Indianapolis Union Station station. The journey, including transfers, takes approximately 19h 40m.
St. Louis to Buffalo bus services, operated by Greyhound USA, depart from St Louis Bus Station.
St. Louis to Buffalo bus services, operated by Greyhound USA, arrive at Buffalo, NY station.
Book your St. Louis to Buffalo bus tickets online with Greyhound USA and Barons Bus.
The distance between St. Louis and Buffalo is 1,063.3 km. The road distance is 1,232 km.
You can take a bus from St Louis Bus Station to Buffalo, NY via Indianapolis, IN, Toledo, and Cleveland, OH in around 16h 15m.
