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How to get fromSt. Louis to Buffaloby plane, train (Amtrak), bus (Greyhound), car, bus or shuttle

Find Transport to Buffalo

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There are 7 ways to get from St. Louis to Buffalo by plane, train (Amtrak), bus (Greyhound), car, bus, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF)planeSTL - BUF
    6h 32m
    $306–1,782

  2. Bus via Reading

    cheapest
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus
    2. Take the bus from Indianapolis Union Station to Cincinnati Bus Stationbus
    3. Take the bus from Cincinnati, OH to Buffalo, NYbus
    17h 40m
    $103–234

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union StationtrainLincoln Service / ...
    2. Take the train from Chicago Union Station to Buffalo Depew StationtrainLake Shore Limited
    17h 39m
    $106–597

  4. Drive 736.3 mi

    1. Drive from St. Louis to Buffalocar736.3 mi
    12h 27m
    $135–195

  5. Fly to Rochester, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Rochester (ROC)planeSTL - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus
    8h 35m
    $186–1,038

  6. Fly to Toronto Pearson International Airport, shuttle

    1. Fly from Lambert–St. Louis International Airport (STL) to Toronto Pearson International Airport (YYZ)planeSTL - YYZ
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle
    8h 17m
    $346–952

  7. Bus

    1. Take the bus from St Louis Bus Station to Pittsburgh Intermodal StationbusGreyhound US0421
    2. Take the bus from Pittsburgh to BuffalobusFab510
    21h 45m
    $122–357

St. Louis to Buffalo by train (Amtrak)

Calendar14Weekly Trains
Duration17h 39mAverage Duration
Ticket$106Cheapest Price
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Questions & Answers

What companies run services between St. Louis, MO, USA and Buffalo, NY, USA?

Delta, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a train from St. Louis to Buffalo via Chicago Union Station and Buffalo Depew Station in around 17h 39m.

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