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How to get fromSt. Louis to Buffaloby plane, bus (Greyhound), train (Amtrak), car, bus or shuttle

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There are 7 ways to get from St. Louis to Buffalo by plane, bus (Greyhound), train (Amtrak), car, bus, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF)plane plane STL - BUF
    6h 31m
    $266–1,582

  2. Bus via Indianapolis

    cheapest
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis, IN to Toledobus bus
    3. Take the bus from Toledo Bus Stop to Cleveland Bus Stationbus bus
    4. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    16h 30m
    $84–225

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    17h 39m
    $99–366

  4. Drive 736.3 mi

    1. Drive from St. Louis to Buffalocar car 736.3 mi
    12h 33m
    $135–195

  5. Fly to Rochester, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Rochester (ROC)plane plane STL - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus bus
    8h 42m
    $186–1,038

  6. Fly to Toronto Pearson International Airport, shuttle

    1. Fly from Lambert–St. Louis International Airport (STL) to Toronto Pearson International Airport (YYZ)plane plane STL - YYZ
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    8h 17m
    $362–952

  7. Bus

    1. Take the bus from St Louis Bus Station to Pittsburgh Intermodal Stationbus bus Greyhound US0421
    2. Take the bus from Pittsburgh to Buffalobus bus Fab510
    21h 45m
    $100–345

St. Louis to Buffalo by bus

Calendar7Weekly Buses
Duration16h 30mAverage Duration
Ticket$84Cheapest Price
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Questions & Answers

What companies run services between St. Louis, MO, USA and Buffalo, NY, USA?

Southwest Airlines, Delta, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from St Louis Bus Station to Buffalo, NY via Indianapolis, IN, Toledo Bus Stop, Cleveland Bus Station, and Cleveland, OH in around 16h 30m.

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