Rome2Rio

Gainesville to Buffalo buses

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Trip Overview

The bus between Gainesville and Buffalo takes 2d 1h. The bus runs, on average, 3 times per week from Gainesville to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 1h
Duration
1,409 mi
Distance
$289
Average price
3 times a week
Frequency

Gainesville to Buffalo bus times

Buses run 3 times a week between Gainesville and Buffalo. The service departs Gainesville at 3:40 PM in the afternoon, which arrives into Buffalo at 17:25:00. All services require a transfer at Jacksonville and take an average of 2d 1h. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAGreyhound USA2d 1h • 2 changes

Departing Wednesday, November 18, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAFlixbus USA2d 1h • 2 changes

Departing Thursday, November 19, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAFlixbus USA2d 1h • 2 changes

Frequently asked questions

Want to know about travelling from Gainesville to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Gainesville to Buffalo.ExpandLaunch map view
  • Distance: 1,409.5 mi
  • Duration: 2d 1h

What companies run services between Gainesville, FL, USA and Buffalo, NY, USA?

You can take a bus from Gainesville to Buffalo via Jacksonville and Newark Penn Station in around 29h 10m.

Operators