Harlem to Buffalo bus times
Buses run 4 times a day between Harlem and Buffalo. The earliest departure is at 4:38 AM at night, and the last departure from Harlem is at 7:08 PM which arrives into Buffalo at 4:00 AM. All services require a transfer at 34 St-Penn Station and take an average of 9h 18m. The schedules shown below are for the next available departures.
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8h 57m • 1 change
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9h 28m • 1 change
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9h 49m • 1 change
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Arrives next day
8h 52m • 1 change
Departing Monday, July 20, 2026
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8h 57m • 1 change
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9h 28m • 1 change
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9h 49m • 1 change
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Arrives next day
8h 52m • 1 change
Departing Tuesday, July 21, 2026
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8h 57m • 1 change
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9h 28m • 1 change
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9h 49m • 1 change
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Arrives next day
8h 52m • 1 change
Departing Wednesday, July 22, 2026
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8h 57m • 1 change
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9h 28m • 1 change
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9h 49m • 1 change
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Arrives next day
8h 52m • 1 change
