The average bus between Harlem and Buffalo takes 9h 49m and the fastest bus takes 9h 20m. The bus service runs several times per day from Harlem to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Harlem and Buffalo. The earliest departure is at 6:55 AM in the morning, and the last departure from Harlem is at 11:04 PM which arrives into Buffalo at 8:45 AM. All services require a transfer at 7 Av/W 31 St and take an average of 9h 49m. The schedules shown below are for the next available departures.

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Arrives next day

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9h 45m • 1 change
Want to know about travelling from Harlem to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Harlem to Buffalo. However, there are services departing from Harlem station and arriving at Buffalo station via Buffalo. The journey, including transfers, takes approximately 9h 49m.
Harlem to Buffalo bus services, operated by MTA Bus Company, depart from New York Midtown station.
Harlem to Buffalo bus services, operated by MTA Bus Company, arrive at Buffalo station.
The distance between Harlem and Buffalo is 469.3 km. The road distance is 686 km.
Flixbus USA operates a bus from New York Midtown to Buffalo every 3 hours. Tickets cost $55–90 and the journey takes 7h 55m.