The average bus between Pisa and Sistine Chapel takes 6h 28m and the fastest bus takes 5h 36m. The bus service runs several times per day from Pisa to Sistine Chapel. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Pisa and Sistine Chapel. The earliest departure is at 12:25 AM at night, and the last departure from Pisa is at 10:00 PM which arrives into Sistine Chapel at 6:06 AM. All services require a transfer at Roma, Autostazione Tiburtina and take an average of 6h 28m. The schedules shown below are for the next available departures.

6h 11m • 1 change
6h 1m • 1 change
6h 16m • 1 change
6h 3m • 1 change
6h 14m • 1 change
5h 54m • 1 change
6h 3m • 1 change
5h 57m • 1 change
6h 14m • 1 change
5h 36m • 1 change
6h 13m • 1 change
6h 9m • 1 change
6h 11m • 1 change
6h 1m • 1 change
6h 16m • 1 change
6h 3m • 1 changeWant to know about travelling from Pisa to Sistine Chapel? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pisa to Sistine Chapel. However, there are services departing from Pisa station and arriving at Sistine Chapel station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 6h 28m.
Pisa to Sistine Chapel bus services, operated by FlixBus, depart from Pisa station.
Pisa to Sistine Chapel bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
The distance between Pisa and Sistine Chapel is 261.3 km. The road distance is 347 km.
FlixBus operates a bus from Pisa to Roma, Autostazione Tiburtina 3 times a day. Tickets cost €27–45 and the journey takes 4h 45m.