The average bus between Colosseum and Sistine Chapel takes 25 min and the fastest bus takes 17 min. The bus runs at least 3 times per hour from Colosseum to Sistine Chapel. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 20 minutes between Colosseum and Sistine Chapel. The earliest departure is at 12:23 AM at night, and the last departure from Colosseum is at 4:04 PM which arrives into Sistine Chapel at 4:28 PM. All services require a transfer at Colosseo/Fori Imperiali and take an average of 25 min. The schedules shown below are for the next available departures.

20 min • 1 change

19 min • 1 change

17 min • 1 change

17 min • 1 change
Want to know about travelling from Colosseum to Sistine Chapel? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Colosseum to Sistine Chapel. However, there are services departing from Colosseum station and arriving at Sistine Chapel station via Argentina. The journey, including transfers, takes approximately 25 min.
Colosseum to Sistine Chapel bus services, operated by ATAC S.p.A. Azienda per la mobilità, depart from Colosseo/Fori Imperiali station.
Colosseum to Sistine Chapel bus services, operated by ATAC S.p.A. Azienda per la mobilità, arrive at Cavalleggeri/S. Pietro station.
The distance between Colosseum and Sistine Chapel is 3.4 km. The road distance is 5 km.
You can take a vehicle from Colosseum to Sistine Chapel via Colosseo/Fori Imperiali, Argentina, and Cavalleggeri/S. Pietro in around 36 min.