The average train between Pisa and Sistine Chapel takes 4h 55m and the fastest train takes 2h 44m. The train service runs several times per day from Pisa to Sistine Chapel. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Pisa and Sistine Chapel. The earliest departure is at 7:33 AM in the morning, and the last departure from Pisa is at 8:38 PM which arrives into Sistine Chapel at 6:40 AM. All services require a transfer at Roma Tiburtina and take an average of 4h 55m. The schedules shown below are for the next available departures.

2h 44m • 1 change

3h 2m • 1 change
Arrives next day

10h 2m • 1 change

2h 44m • 1 change

3h 2m • 1 change
Arrives next day

10h 2m • 1 change
Want to know about travelling from Pisa to Sistine Chapel? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Pisa to Sistine Chapel. However, there are services departing from Pisa station and arriving at Sistine Chapel station via Roma Tiburtina. The journey, including transfers, takes approximately 4h 55m.
Pisa to Sistine Chapel train services, operated by Trenitalia Frecce, depart from Pisa Centrale station.
Pisa to Sistine Chapel train services, operated by Trenitalia Frecce, arrive at Roma Tiburtina station.
Book your Pisa to Sistine Chapel train tickets online with Trenitalia Frecce and Trenitalia.
The distance between Pisa and Sistine Chapel is 261.3 km. The road distance is 345 km.
Trenitalia Frecce operates a train from Pisa Centrale to Roma Tiburtina twice daily. Tickets cost €45–95 and the journey takes 2h 9m.