The average train between Pisa and Sistine Chapel takes 4h 7m and the fastest train takes 3h 1m. The train service runs several times per day from Pisa to Sistine Chapel. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Pisa and Sistine Chapel. The earliest departure is at 5:45 AM in the morning, and the last departure from Pisa is at 7:45 PM which arrives into Sistine Chapel at 5:23 AM. All services require a transfer at Civitavecchia and take an average of 4h 7m. The schedules shown below are for the next available departures.

4h 9m • 1 change

3h 47m • 1 change

3h 32m • 1 change

3h 17m • 1 change

4h 9m • 1 change

3h 17m • 1 change

3h 17m • 1 change

3h 17m • 1 change

4h 9m • 1 change

3h 17m • 1 change

3h 17m • 1 change

3h 17m • 1 change

4h 9m • 1 change

3h 17m • 1 change

3h 17m • 1 change

3h 17m • 1 change

4h 9m • 1 change

3h 17m • 1 change

3h 17m • 1 change

3h 17m • 1 change
Want to know about travelling from Pisa to Sistine Chapel? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Pisa to Sistine Chapel. However, there are services departing from Pisa station and arriving at Sistine Chapel station via Civitavecchia. The journey, including transfers, takes approximately 4h 7m.
Pisa to Sistine Chapel train services, operated by Trenitalia, depart from Pisa Centrale station.
Pisa to Sistine Chapel train services, operated by Trenitalia, arrive at Roma S. Pietro station.
Book your Pisa to Sistine Chapel train tickets online with Trenitalia, Trenitalia Frecce and Trenitalia Intercity.
The distance between Pisa and Sistine Chapel is 261.3 km. The road distance is 321 km.
You can take a train from Pisa Centrale to Sistine Chapel via Civitavecchia and Roma S. Pietro in around 3h 36m.