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Pisa to Sistine Chapel trains

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Trip Overview

The average train between Pisa and Sistine Chapel takes 5h 5m and the fastest train takes 2h 44m. The train service runs several times per day from Pisa to Sistine Chapel. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 5m
Duration
345 km
Distance
€56
Average price
Twice daily
Frequency

Pisa to Sistine Chapel train times

Trains run twice daily between Pisa and Sistine Chapel. The earliest departure is at 7:33 AM in the morning, and the last departure from Pisa is at 8:38 PM which arrives into Sistine Chapel at 6:40 AM. All services require a transfer at Roma Tiburtina and take an average of 5h 5m. The schedules shown below are for the next available departures.

Departing Monday, November 16, 2026

  •  → 

    Trenitalia FrecceTrenitalia3h 2m • 1 change
  •  → 

    Arrives next day

    Trenitalia FrecceTrenitalia10h 2m • 1 change

Departing Tuesday, November 17, 2026

  •  → 

    Trenitalia FrecceTrenitalia2h 44m • 1 change
  •  → 

    Trenitalia FrecceTrenitalia3h 2m • 1 change
  •  → 

    Arrives next day

    Trenitalia FrecceTrenitalia10h 2m • 1 change

Departing Wednesday, November 18, 2026

  •  → 

    Trenitalia FrecceTrenitalia2h 44m • 1 change
  •  → 

    Trenitalia FrecceTrenitalia3h 2m • 1 change
  •  → 

    Arrives next day

    Trenitalia FrecceTrenitalia10h 2m • 1 change

Departing Thursday, November 19, 2026

  •  → 

    Trenitalia FrecceTrenitalia2h 44m • 1 change
  •  → 

    Trenitalia FrecceTrenitalia3h 2m • 1 change
  •  → 

    Arrives next day

    Trenitalia FrecceTrenitalia10h 2m • 1 change

Departing Friday, November 20, 2026

  •  → 

    Trenitalia FrecceTrenitalia2h 44m • 1 change
  •  → 

    Trenitalia FrecceTrenitalia3h 2m • 1 change

Frequently asked questions

Want to know about travelling from Pisa to Sistine Chapel? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Pisa to Sistine Chapel.ExpandLaunch map view
  • Distance: 345.2 km
  • Duration: 5h 5m

What companies run services between Pisa, Italy and Sistine Chapel, Vatican City?

Trenitalia Frecce operates a train from Pisa Centrale to Roma Tiburtina 5 times a day. Tickets cost €45–80 and the journey takes 2h 9m.

Operators