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How to get fromPisa to Sistine Chapelby train (Trenitalia), bus, car, plane or train

Find Transport to Sistine Chapel

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There are 7 ways to get from Pisa to Sistine Chapel by train (Trenitalia), bus, car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train via Roma Tiburtina (Trenitalia)

    best
    1. Take the train from Pisa Centrale to Roma Tiburtinatrain train Fa
    3h 9m
    €31–68
  2. Bus

    cheapest
    1. Take the bus from Pisa to Roma, Autostazione Tiburtinabus bus N1508 / ...
    5h 50m
    €13–28
  3. Drive 324.3 km

    1. Drive from Pisa to Sistine Chapelcar car 324.3 km
    3h 46m
    €51–73
  4. Fly from Pisa International Airport

    1. Fly from Pisa International Airport (PSA) to Fiumicino International Airport (FCO)plane plane PSA - FCO
    5h 3m
    €56–211
  5. Train

    1. Take the train from Pisa Centrale to Roma S. Pietrotrain train 4125 / ...
    3h 56m
    €20–60
  6. Train via Florence

    1. Take the train from Pisa Centrale to Firenze S.M.N.train train Re / ...
    2. Take the train from Florence Santa Maria Novella to Roma Terminitrain train 8959 / ...
    4h 3m
    €40–80
  7. Train to Florence Peretola Airport, fly

    1. Take the train from Pisa Centrale to Firenze S.M.N.train train
    2. Fly from Florence Peretola Airport (FLR) to Fiumicino International Airport (FCO)plane plane FLR - FCO
    4h 49m
    €78–224

Pisa to Sistine Chapel by train and foot (Trenitalia)

Calendar13Weekly Services
Duration3h 9mAverage Duration
Ticket€31Cheapest Price
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Questions & Answers

What companies run services between Pisa, Italy and Sistine Chapel, Vatican City?

Trenitalia Frecce operates a train from Pisa Centrale to Roma Tiburtina twice daily. Tickets cost €29–65 and the journey takes 2h 9m. Alternatively, FlixBus operates a bus from Pisa to Roma, Autostazione Tiburtina 4 times a day. Tickets cost €12–21 and the journey takes 4h 45m.

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Want to know more about travelling around Vatican City

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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