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How to get fromPisa to Sistine Chapelby train, bus, car, plane or train (Trenitalia)

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There are 8 ways to get from Pisa to Sistine Chapel by train, bus, car, plane, or train (Trenitalia)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train via Florence

    best
    1. Take the train from Pisa Centrale to Firenze S.M.N.trainRe / ...
    2. Take the train from Florence Santa Maria Novella to Roma Terminitrain8959 / ...
    3h 47m
    €42–75
  2. Bus

    cheapest
    1. Take the bus from Pisa to Roma, Autostazione TiburtinabusN1508 / ...
    5h 52m
    €13–37
  3. Drive 324.3 km

    1. Drive from Pisa to Sistine Chapelcar324.3 km
    3h 43m
    €51–74
  4. Fly from Pisa International Airport

    1. Fly from Pisa International Airport (PSA) to Fiumicino International Airport (FCO)planePSA - FCO
    4h 18m
    €54–220
  5. Train

    1. Take the train from Pisa Centrale to Roma S. Pietrotrain4131 / ...
    3h 56m
    €20–60
  6. Bus via Anagnina

    1. Take the bus from Pisa to Roma - Via Vincenzo Giudicebus
    7h 47m
    €34–64
  7. Train to Florence Peretola Airport, fly

    1. Take the train from Pisa Centrale to Firenze S.M.N.train
    2. Fly from Florence Peretola Airport (FLR) to Fiumicino International Airport (FCO)planeFLR - FCO
    4h 49m
    €82–248
  8. Train, train to Bologna Guglielmo Marconi Airport, fly

    1. Take the train from Pisa Centrale to Firenze S.M.N.train
    2. Take the train from Firenze S.M.N. to Bologna Centraletrain
    3. Fly from Bologna Guglielmo Marconi Airport (BLQ) to Fiumicino International Airport (FCO)planeBLQ - FCO
    5h 32m
    €78–295

Pisa to Sistine Chapel by train, subway, and foot

Calendar184Weekly Services
Duration3h 47mAverage Duration
Ticket€42Cheapest Price
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Questions & Answers

What companies run services between Pisa, Italy and Sistine Chapel, Vatican City?

You can take a train from Pisa Centrale to Sistine Chapel via Florence Santa Maria Novella, Rome Termini, Termini, and Ottaviano in around 3h 47m. Alternatively, FlixBus operates a bus from Pisa to Roma, Autostazione Tiburtina 4 times a day. Tickets cost €12–30 and the journey takes 4h 45m.

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