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How to get fromPisa to Sistine Chapelby train (Trenitalia), bus, car, plane, or train

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There are 10 ways to get from Pisa to Sistine Chapel by train (Trenitalia), bus, car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train via Roma Tiburtina (Trenitalia)

    best
    1. Take the train from Pisa Centrale to Roma Tiburtinatrain train Fa
    3h 9m
    €51–99

  2. Bus via Rome Fiumicino Airport Bus Station

    cheapest
    1. Take the bus from Pisa to Fiumicino Aeroporto T3bus bus N548
    5h 56m
    €28–47

  3. Drive 324.3 km

    1. Drive from Pisa to Sistine Chapelcar car 324.3 km
    3h 46m
    €51–74

  4. Fly Pisa International Airport to Fiumicino International Airport

    1. Fly from Pisa International Airport (PSA) to Fiumicino International Airport (FCO)plane plane PSA - FCO
    4h 8m
    €49–197

  5. Train (Trenitalia)

    1. Take the train from Pisa Centrale to Roma S. Pietrotrain train 4125 / ...
    3h 57m
    €30–70

  6. Bus

    1. Take the bus from Pisa to Roma - Via Vincenzo Giudicebus bus
    7h 58m
    €34–64

  7. Fly Pisa International Airport to Roma Ciampino Airport

    1. Fly from Pisa International Airport (PSA) to Roma Ciampino Airport (CIA)plane plane PSA - CIA
    4h 36m
    €59–249

  8. Bus to Florence Peretola Airport, fly to Fiumicino International Airport

    1. Take the bus from Pisa International Airport to Florence Airportbus bus
    2. Fly from Florence Peretola Airport (FLR) to Fiumicino International Airport (FCO)plane plane FLR - FCO
    4h 10m
    €80–219

  9. Train, train to Bologna Guglielmo Marconi Airport, fly to Fiumicino International Airport

    1. Take the train from Pisa Centrale to Firenze S.M.N.train train
    2. Take the train from Firenze S.M.N. to Bologna Centraletrain train
    3. Fly from Bologna Guglielmo Marconi Airport (BLQ) to Fiumicino International Airport (FCO)plane plane BLQ - FCO
    5h 35m
    €62–222

  10. Train to Genoa Cristoforo Colombo Airport, fly to Fiumicino International Airport

    1. Take the train from Pisa Centrale to Genova P.Za Principetrain train
    2. Fly from Genoa Cristoforo Colombo Airport (GOA) to Fiumicino International Airport (FCO)plane plane GOA - FCO
    6h 2m
    €65–245

Pisa to Sistine Chapel by train and foot (Trenitalia)

Calendar19Weekly Services
Duration3h 9mAverage Duration
Ticket€51Cheapest Price
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Questions & Answers

Map of how to get from Pisa to Sistine Chapel.ExpandLaunch map view
  • Distance: 345.2 km
  • Duration: 3h 9m

What companies run services between Pisa, Italy and Sistine Chapel, Vatican City?

Trenitalia Frecce operates a train from Pisa Centrale to Roma Tiburtina 3 times a day. Tickets cost €45–100 and the journey takes 2h 9m. Alternatively, FlixBus operates a bus from Pisa to Fiumicino Aeroporto T3 once daily. Tickets cost €26–45 and the journey takes 4h 35m.

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Want to know more about travelling around Vatican City

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