The average bus between Pisa and Sicily takes 23h 35m and the fastest bus takes 22h 32m. The bus service runs several times per day from Pisa to Sicily. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Pisa and Sicily. The earliest departure is at 4:45 AM at night, and the last departure from Pisa is at 5:10 PM which arrives into Sicily at 3:43 PM. All services require a transfer at Florence Villa Constanza Bus Station and take an average of 23h 35m. The schedules shown below are for the next available departures.
Arrives next day


23h 23m • 2 changes
Arrives next day


22h 33m • 2 changes
Arrives next day


23h 27m • 2 changes
Arrives next day


22h 32m • 2 changes
Arrives next day


23h 23m • 2 changes
Arrives next day


22h 33m • 2 changes
Arrives next day


23h 23m • 2 changes
Arrives next day


22h 33m • 2 changes
Want to know about travelling from Pisa to Sicily? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pisa to Sicily. However, there are services departing from Pisa station and arriving at Sicily station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 23h 35m.
Pisa to Sicily bus services, operated by FlixBus, depart from Pisa station.
Pisa to Sicily bus services, operated by FlixBus, arrive at Palermo station.
The distance between Pisa and Sicily is 750.4 km. The road distance is 1,359 km.
You can take a bus from Pisa to Piazza Boiardo via Florence Villa Constanza Bus Station, Palermo, and Stazione Centrale Pensilina Esterna in around 19h 29m.