The average bus between Isernia and Roma Termini takes 2h 43m and the fastest bus takes 2h 29m. The bus service runs several times per day from Isernia to Roma Termini. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Isernia and Roma Termini. The earliest departure is at 6:50 AM in the morning, and the last departure from Isernia is at 6:20 PM which arrives into Roma Termini at 8:58 PM. All services require a transfer, and take on average 2h 43m. The schedules shown below are for the next available departures.

2h 46m • 1 change

2h 42m • 1 change

2h 51m • 1 change

2h 44m • 1 change

2h 46m • 1 change

2h 42m • 1 change

2h 51m • 1 change

2h 44m • 1 change

2h 46m • 1 change

2h 42m • 1 change

2h 51m • 1 change

2h 44m • 1 change

2h 46m • 1 change

2h 42m • 1 change

2h 51m • 1 change

2h 44m • 1 change
Want to know about travelling from Isernia to Roma Termini? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Isernia to Roma Termini. However, there are services departing from Isernia station and arriving at Roma Termini station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 2h 43m.
Isernia to Roma Termini bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., depart from Isernia station.
Isernia to Roma Termini bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., arrive at Roma, Autostazione Tiburtina station.
The distance between Isernia and Roma Termini is 147.6 km. The road distance is 178 km.
ATM Azienda di Trasporti Molisana S.p.A. operates a bus from Isernia to Roma, Autostazione Tiburtina 3 times a day. Tickets cost €8–13 and the journey takes 2h 10m. FlixBus also services this route once daily.