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The average bus between Indianapolis and St. Louis takes 4h 26m and the fastest bus takes 3h 55m. The bus service runs several times per day from Indianapolis to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Indianapolis and St. Louis. The earliest departure is at 4:55 AM at night, and the last departure from Indianapolis is at 7:55 PM which arrives into St. Louis at 10:50 PM. All services run direct with no transfers required, and take on average 4h 26m. The schedules shown below are for the next available departures.
Want to know about travelling from Indianapolis to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
Yes, there is a direct bus departing from Indianapolis Union Station and arriving at St Louis Bus Station. Services depart three times a day, and operate every day. The journey takes approximately 4h 26m.
Indianapolis to St. Louis bus services, operated by Greyhound USA, depart from Indianapolis Union Station.
Indianapolis to St. Louis bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Book your Indianapolis to St. Louis bus tickets online with Omio and FlixBus.
The distance between Indianapolis and St. Louis is 370.5 km. The road distance is 389 km.
Greyhound USA operates a bus from Indianapolis Union Station to St Louis Bus Station 3 times a day. Tickets cost $40–65 and the journey takes 3h 55m.
